The <i>P[syt^P-L]</i> mutation decreases the Ca²⁺ affinity of release and vesicular release probability, but the readily releasable pool is unchanged. by Mallory C. Shields (4474210)

“…Application of bath solution does not result in an increase in mEJP frequency in either genotype (open circles) (p = 0.57 for <i>+/-; P[syt^WT]/+</i> and p = 0.83 for <i>+/-;P[syt^P-L]/+</i>, student t-test). Scale bar 2mV, 3s. (D) Paired-pulse analysis indicates a decrease in release probability in <i>+/-;P[syt^P-L]/+</i>. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

<i>btuE</i> expression results in decreased intracellular ROS. by Felipe A. Arenas (23050)

(R)-albuterol decreases cytokine mRNA levels in activated T cells by Marcela A Ferrada (41716)

“…</p><p></p> (R)-albuterol, (S)-albuterol or racemic albuterol (R + S) at a dose (10M) were added to T (EL-4) cells pre-activated with mitogens Concanavalin A (Con A, 5 μg/ml) and phorbol myristate acetate (PMA, 100 ng/ml) (CP). …”

Fig 5 - by Maha Rehman (17114332)

(A) CaMKII inhibition by KN-93 or AIP, or calmodulin inhibition by W-7 decreases O₂ consumption in SANC suspension (n = 5 for each drug), (B) AIP decreases mitochondrial flavoprotein fluorescence in single SANC (representative example), indicating a net reduction of flavoprotein pool. by Yael Yaniv (162548)

Presence of tumor-associated macrophage (TAM) F4/80 and tumor-associated neutrophil (TAN) Ly6G in xenotransplanted mice are suppressed by PLD inhibitors. by Karen M. Henkels (3350273)

Subjects: “…Liver Metastases Phospholipase D -2…”

Decreased levels of vitamin D3 and supplementation with 1,25-dihydroxyvitamin D3-glycoside on performance, carcass yield and bone quality in broilers by Osvanira dos Santos Alves (5555027)

“…Seven-d-old male chickens Cobb500® were distributed in a randomized design with six treatments: a control diet with inclusion of vitamin D3 in the premix, without supplementation of 1,25(OH)2D3-glycoside, and five diets with decreased levels of vitamin D3 (100%, 75%, 50%, 25% and 0% about the control) plus the addition of 1,25(OH)2D3-glycoside, 50g ton-1 of diet. …”

Ghrelin prevents the loss of CD4 T cells after sepsis. by Mian Zhou (339595)

Ghrelin modulates the expression of cell cycle regulatory proteins in sepsis. by Mian Zhou (339595)

Sepsis induces the expression of apoptosis-related proteins in the spleen. by Mian Zhou (339595)

UGGT activity decreases in <i>uggt-1(RNAi)</i> worms but no decrease was observed in <i>uggt-2 (RNAi)</i> worms. by Lucila I. Buzzi (198284)

Levels of the antioxidant enzyme, MnSOD are decreased in the cortical and hippocampal microvessels. by Susan A. Austin (768265)

Sepsis alters the expression of cell cycle proteins in the spleen. by Mian Zhou (339595)

Dynamics of nocodazole washout upon Mad2 overexpression. by Alma Beatrix Stier (20903134)

Aspirin-Triggered Resolvin D1 Attenuated IL-1β-induced Cytokine/Chemokine Secretion. by Ruan Cox Jr. (789575)

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

Specific inhibition of ATG5 and ATG7 decrease low glucose-induced LC3-II accumulation. by Delphine Balmer (458897)

“…<p>Lentiviruses expressing specific shRNA were used to decrease the expression of ATG5 and ATG7 as described in material & methods, then each clonal cell colony was treated and cultured as mentioned in material & methods. …”

Decadal mean regional hydrology. by Nic Gedney (19762301)