Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

RT-qPCR evaluation of MYD88, NLRP3, and NFκβ in GA 18.5 pup brains. by Adrienne J. Bradley (20861948)

Reverse activation tendency decreases for spikes occurring later in SWRs by Jozsef Csicsvari (82625)

Table_1_Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-li... by Yan Zhou (6523)

“…Patients with vitamin D deficiency (Lo) had varying degrees of elevation of the pro-inflammatory cytokines IL-5, IL-6, and IL-17A, decreased expression of the anti-inflammatory cytokine IL-10, and altered forced expiratory volume in the first second as a percentage of predicted value (FEV₁%pred) in both asthmatic endotypes. …”

Table_3_Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-li... by Yan Zhou (6523)

“…Patients with vitamin D deficiency (Lo) had varying degrees of elevation of the pro-inflammatory cytokines IL-5, IL-6, and IL-17A, decreased expression of the anti-inflammatory cytokine IL-10, and altered forced expiratory volume in the first second as a percentage of predicted value (FEV₁%pred) in both asthmatic endotypes. …”

Table_4_Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-li... by Yan Zhou (6523)

“…Patients with vitamin D deficiency (Lo) had varying degrees of elevation of the pro-inflammatory cytokines IL-5, IL-6, and IL-17A, decreased expression of the anti-inflammatory cytokine IL-10, and altered forced expiratory volume in the first second as a percentage of predicted value (FEV₁%pred) in both asthmatic endotypes. …”

LY5 inhibits STAT3 phosphorylation in lung metastases but does not inhibit lung metastasis formation. by Peter Y. Yu (4281448)

The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response - Fig 2 by Varpu Elenius (114547)

“…Rhinovirus (RV), bocavirus-1 (BoV), adenovirus (AdV), enteroviruses (EV), coronavirus (CV), parainfluenza virus types 1–4 (PIV), metapneumovirus (MPV), influenza A or B virus (Flu), respiratory syncytial virus (RSV). …”

Table_1_NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial.DOCX by Jean Gérain (16415511)

“…The clinical condition of participants in the Nasafytol^® arm had improved, as evidenced by a decrease in the COVID-19 WHO score. Interestingly, five SAEs occurred with Fultium^®, while no SAE was observed with Nasafytol^®.…”

Examples of drawings made by children in the M2 –after the first field trip (a, b) and M3 –after the second field trip and laboratory class (c, d). by Maria João Feio (11169654)

Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

“…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”

Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

“…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”

Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

“…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”

Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

“…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”

Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

“…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”

FSL of MSO neurons in relation to click intensity, frequency, and within the same animal. by Martijn C. Sierksma (11608174)

The phosphorylation of Mas receptor and its induced-effects in <i>hGRK4</i> <i>γ</i> WT and 142V transgenic mice. by Lin Chen (54305)

FGF10 dose dependency of the cellular response in E13.5 (black) and E14.5 (blue) epithelium. by Hisako Takigawa-Imamura (3175320)

Cas9 and LOF allele behavior in a 3 population model. by Georg Oberhofer (3401438)

Fig 5 - by Melissa A. Johnson (3847954)