A decreased neurovirulence is observed for rOC/S_G758R variant in 21 day-old BALB/c female mice infected by the intracerebral route. by Alain Le Coupanec (421447)

The Rac1-64D mutation caused decreased Rac1 binding to PAK. by Fumin Chang (193521)

Berberine inhibits 4-AP-induced glutamate release from rat cerebrocortical nerve terminals; this effect is due to a decrease in vesicular exocytosis. by Tzu-Yu Lin (423761)

“…<p>Glutamate release (+Ca²⁺; A) and Ca²⁺-independent glutamate release (-Ca²⁺; C) was measured under control conditions or in the presence of 10 µM berberine added 10 min prior to the addition of 4-AP. …”

PKCε activation induces aggrecan gene expression, decreases ADAMTS5, and detection of ADAMTS-5-depended cleavage of ECM aggrecan through upregulation of hsa-miR-377 expression. by Emmanouella Tsirimonaki (490707)

“…<p>(<b>A</b>) RT-PCR detected the relative expression of ACAN, MKI67, ADAMTS5 after treatment of NP cells with 1 μM ψεRACK (or vehicle) for indicated times and revealed that time-dependent activation of PKCε significantly increased the mRNA expression for aggrecan, while in an opposing manner decreased ADAMTS5; mRNA levels of the proliferation marker Ki67 became barely detectable after 8 hours of PKCε activation. …”

Increased BBB disruption, with a decrease in endothelial ZO-1, claudin-5 and occludin, avoided by GM6001. by Saran Feng (345936)

Ibuprofen and diclofenac decrease migration. by Verena Leidgens (815986)

Vectorized siRNA TMPRSS2-ERG IV-SQ impaired tumour growth and restored differentiation <i>in vivo</i>. by Giorgia Urbinati (554921)

“…<b>d.</b> Immunohistochemical analysis revealed a decreased Ki67 positive nuclei only in the tumours treated with NPs siRNA TMPRSS2-ERG IV-SQ. …”

IFN-β signalling pathway stimulation by Poly(I:C) decreased 5’terminally deleted CVB3 RNA forms viral loads, cardiac lesions and mortality in DBA/2J mice. by Domitille Callon (17723936)

Decreased ubiquitination in the dTAK1^K156R mutant. by Merennege Dilan Anush Fernando (525297)

“…Expression vectors encoding dTAK1-V5 or dTAK1^K156R -V5 were transfected along with dTAB2-HA and cMyc-Ub in combinations shown in S2 cells. …”

Ibuprofen and diclofenac decrease proliferation. by Verena Leidgens (815986)

“…<p>Proliferation was analyzed using crystal violet staining and results were verified via the CyQuant Direct Cell Proliferation assay in HTZ-349. (A) Starting at 72 h, all ibuprofen concentrations (0.5, 1, 2 mM) resulted in significant reduction of HTZ-349 proliferation (compared to non-treated Ctrl, 95% CI, p < 0.05). 2 mM ibuprofen caused significant proliferation inhibition at 24 h (0.01 > p ≤ 0.001) and 48 h (p < 0.0001). …”

Depletion of PfPKAc in NF54/AP2-G-mScarlet/PKAc cKD parasites leads to a block in merozoite invasion and decreases gametocyte rigidity. by Eva Hitz (10877688)

Success rates increase and number of topics decrease as research activity levels increase. by Mark D. Lindner (748770)

Annual number of outpatient visits in recurrence and non-recurrence groups. by Yasuyuki Sotani (20114144)

“…<p>In the recurrence group, mean outpatient visits (± standard deviation) decreased from 13.6 ± 3.0 to 11.9 ± 5.0, 8.1 ± 3.9, and 7.8 ± 3.2 at 1, 2, and 3 years postoperatively, respectively (Kruskal-Wallis test, P < 0.001; Dunn’s test, **P < 0.01). …”

IL-10^−/− mice develop a less severe PCM associated with increased cellular immunity that results in decreased mortality rates. by Tânia A. Costa (440296)

SUR1Δ/LDLR^-/- mice have increased fasting glucose levels and impaired glucose tolerance with decreased insulin secretion. by Erika Gurzeler (4781904)

Tebuconazole decreased secreted Aβ42 levels in CHO PS1 ΔE9 cells but not in PS1 WT cells. by Yoon Young Cho (838272)

Accumulation of mononuclear leukocyte and CD4⁺ and CD8⁺ T cells is decreased in the brains of infected α_D ^-/- mice. by Isaclaudia G. de Azevedo-Quintanilha (8173734)

Long-lived acceptor dark states can produce bimodal FRET efficiency distributions, multi-exponential donor excited-state decays, and a decrease in measured average FRET efficiency... by Steven S. Vogel (299330)

VPA decreases cell proliferation. by Muriel Rhinn (406515)

Decreased 11ß-HSD1 protein level by IGF-I overexpression <i>in vivo</i> and a direct treatment with IGF-I. by Subrata Chowdhury (787208)

“…N = 4, **P<0.01 vs. untreated. <b>D</b>. IGF-I treatment accelerated 11β-HSD1 protein degradation in 11β-HSD1 overexpressing MIN6 cells (as in Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0136656#pone.0136656.g005" target="_blank">5</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0136656#pone.0136656.g006" target="_blank">6</a>). …”