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wt decrease » we decrease (Expand Search), _ decrease (Expand Search), awd decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
d decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
wt decrease » we decrease (Expand Search), _ decrease (Expand Search), awd decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
d decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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TIMP3 overexpression decreases tibial bone mechanical properties from macroscale to nanoscale mechanics.
Published 2016“…<p>A, Von Kossa staining of tibia epiphysis and metaphysis of WT and TIMP3 Tg/Tg mice showed decreased trabecular bone in TIMP3 Tg/Tg mice (Magnification x2). …”
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The GluN2B-C456Y mutation decreases recombinant NMDAR currents and alters receptor properties.
Published 2020Subjects: -
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Image_2_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2023“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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Image_2_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2022“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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