Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Internalization of FDNVs in colorectal cancer and normal colon epithelial cells. by Saharut Wongkaewkhiaw (9853495)

Characterization of FDNVs. by Saharut Wongkaewkhiaw (9853495)

The ameliorative effect of aerobic exercise on myocardial infarction-induced apoptosis in cardiomyocytes. by Niu Liu (2104450)

Regulation of energy metabolism by SMS during exercise. by Suji Baek (15223705)

Inhibition of pan- and HDAC isoform activities. by Mira Jung (1277502)

“…Cellular growth inhibition studies show that SP-1-303 differentially inhibits growth of estrogen receptor positive breast cancer (ER+ BC) cells with effective growth inhibition concentrations (EC₅₀) for MCF-7 and T47D cells ranging from 0.32 to 0.34 μM, compared to 1.2–2.5 μM for triple negative breast cancer cells, and ~12 μM for normal breast epithelial cells. …”

Latent growth curve model estimating the change in moderate-to-vigorous physical activity (MVPA) from follow-up surveys W1 to W3. by Glen E. Duncan (9238792)

The inhibition of FDNVs internalization in colorectal cells. by Saharut Wongkaewkhiaw (9853495)

Lack of neutrophils at the time of immunization does not affect the induction of adaptive immune responses by the mRNA-LNP platform. by Sonia Ndeupen (11993937)

Stimulation of iNKT Cells with α-GalCer during an Established <i>L. donovani</i> Infection Results in a Decreased Frequency of Hepatic iNKT Cells Producing IFNγ and TNF, and an Inc... by Amanda C. Stanley (42433)

Aerobic exercise improves infarction-induced cardiac dysfunction. by Niu Liu (2104450)

Spectroscopic and Electronic Structural Studies of Blue Copper Model Complexes. 1. Perturbation of the Thiolate−Cu Bond by David W. Randall (1972414)

“…The key spectral differences relative to plastocyanin include an increase in the intensity of the S pπ → Cu CT band and a decrease in the absorption intensity at ∼450 nm. The energies of d → d transitions in <b>1</b> decrease relative to plastocyanin, which reflects the more tetrahedral geometry of <b>1</b>. …”

Neural tracking of speech across linguistic timescales in relation to cognitive decline and hearing ability. by Elena Bolt (20396190)

Parallel process latent growth curve model estimating the parallel changes in moderate-to-vigorous physical activity (MVPA) and anxiety from follow-up surveys W1 to W3. by Glen E. Duncan (9238792)

Supplementary Figure S3 from A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant <i>TP53</i> and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥A... by Eric D. Eisenmann (15013737)

Supplementary Figure S3 from A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant <i>TP53</i> and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥A... by Eric D. Eisenmann (15013737)

Global derepression of miR-142-3p targets and dysregulated IFNγ signaling in <i>miR-142</i>–deficient T_reg cells. by Wei-Le Wang (133402)

Cathepsin B is the main cathepsin involved in the ouabain-induced reduction in PrP^C levels. by Mohadeseh Mehrabian (455336)

A New Gramicidin S Analogue with Potent Antibacterial Activity and Negligible Hemolytic Toxicity by John T. Kalyvas (18858937)

Lost-Wheel assembly and testing. by Joseph J. Bivona III (11864256)