Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

Subjects:

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) by F. Anthony Romero (2452198)

“…Compound <b>19</b> displays antitumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner.…”

A shows the week of vehicle/dFBr injections dFBr in the IA2BC timeline followed by 1 week post-treatment washout period. by Steven Decker (13767223)

“…D. dFBr significantly decreases preference for ethanol at the 24 hr time-point in male SD rats (n = 23/group, Experiment 1+2). …”

DPPIV inhibitor MK626 decreases T1D incidence and reduces the insulitis score in NOD mice. by Núria Alonso (824191)

Decreased cytokine expression in J2.2-HKU1.7b-infected BMDM. by Chaminda D. Gunawardene (22794593)

Islet2a morphant, but not mutant, larvae have a reduced number of dSMNs. by Rosa L. Moreno (5434796)

“…(H) Cell counts indicated that the number of dSMN somas was not reduced in mutant (n = 9) compared to wildtype (n = 5) or heterozygous (n = 8) <i>islet2a</i> 72 hpf embryos.…”

The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients. by Tao Zhang (43681)

“…<p>Representative IHC stains of normal, normal-appearing FAP, and FAP adenomatous colonic crypts are shown for the expression of the: <b>(A)</b> NEC marker chromogranin-A (CGA). <b>(B)</b> SC marker ALDH1. …”

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. by Hope Murphy (8843516)

Decreased cell infiltrates and IFN-γ production of liver mononuclear cells in 2-OA-BSA immunized CD1d^-/- mice. by Chao-Hsuan Chang (712089)

Multiple logistic regression model exploring factors associated with >50% seizures reduction at month 4. by Michel Mandro (2637532)

Mean volume and mean apical surface of chick neuroepithelial cells decreases between 2 and 3 days of development. by Marina A. Ferreira (8174169)

Simultaneous silencing of isoamylases ISA1, ISA2 and ISA3 by multi-target RNAi in potato tubers leads to decreased starch content and an early sprouting phenotype by Stephanus J. Ferreira (4249219)

“…<div><p>Isoamylases hydrolyse (1–6)-alpha-D-glucosidic linkages in starch and are involved in both starch granule formation and starch degradation. …”

Rap2 decreased the barrier resistance. by Willem-Jan Pannekoek (383458)

Effect of heat stress on N1S1 and AS30D cell viability and clonogenic survival. by Scott M. Thompson (231230)

CDA-2 decreases pulmonary inflammation. by Xuan Wang (55634)

DJA2 decreases maturation of CFTR. by Patrick Kim Chiaw (7224539)

Decreased IL-2 responses in ICL. by Florence Bugault (278171)

IL–1β levels and IL–18 expression are markedly decreased in the MyD88^-/- and TLR2^-/- mice. by Deysi V. T. Wong (803817)

The Dose–Response Decrease in Heart Rate Variability: Any Association with the Metabolites of Polycyclic Aromatic Hydrocarbons in Coke Oven Workers? by Xiaohai Li (136211)

“…After adjustment for potential confounders, elevation per interquartile range (IQR) (1.81 µg/mmol creatinine) of urinary 2-hydroxynaphthalene was associated with a 5.46% (95% CI, 2.50–8.32) decrease in standard deviation of NN intervals (SDNN). …”

D2-Survival probability critical load results by Linda Pardo (21401453)