Discovery of Oral AMP-Activated Protein Kinase Activators for Treating Hyperlipidemia by Mingchao Wang (450503)

“…A single dose of V1 (2000 mg) increased AMPK activation in human erythrocytes after 5 and 12 h of treatment. …”

PON2 gene expression exhibits similar trends to the PON2 protein concentration levels measured using Western blot, with a trend towards decreased PON expression in asthma-obese (n = 5, 11.6 ± 0.22; mean ± standard error in VST-normalized messenger RNA levels) compared to lean participants (n = 4, 11.9 ± 0.062). by Daniel Efrain Winnica (12239641)

Gu-4 improves survival in septic rats and this improvement is accompanied by marked decrease of HMGB1 and TNF-α level in serum. by HuiTing Zhou (333755)

<i>Aspergillus flavus</i> mRNA expression (a) <i>aflD</i> and (c) <i>aflR</i> and phylogenetic analysis of (b) <i>aflD</i> and (d) <i>aflR</i> after exposure to 50 mg/mL of <i>U. e... by Martha Cebile Jobe (21175426)

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response by N.N. Dang (6513023)

“…Filaggrin silencing also resulted in significant increases of IL-2, IL-4, IL-5, and IL-13 (P<0.05 or P<0.01), and significant decreases of IL-12p70 and IFN-γ (P<0.01) compared with cells in the Blank and NC groups. …”

Results of a dog’s detections after exposure to sweat samples from positive and negative people to SARS-CoV-2, together with the Ct values of the RT-qPCR test of each person partic... by Víctor M. Vidal-Martínez (18707335)

miR-10b expression positively correlates with B-Raf^V600E mutation status in multiple cell lines. by Ila Datar (433874)

mRNA expression of 7 genes in normal and colorectal cancer biopsy (A) and in HT29 cells after 5-aza-2’-deoxycytidine treatment (B). by Árpád V. Patai (132272)

“…<p><b>A.</b> Compared to normal, CRC showed decreased mRNA expression. …”

Supplementary Material for: Adiponectin Signaling and Impaired GTPase Rab5 Expression in Adipocytes of Adolescents with Obesity by Karvela A. (9534653)

Downregulation of <i>wnt5b</i> during gastrulation by <i>lbx1b</i> overexpression. by Long Guo (548453)

“…<p>(A) <i>In situ</i> hybridization for non-canonical Wnt/PCP ligands (<i>wnt5b</i> and <i>wnt11</i>) in control and <i>lbx1b</i>-overexpressing embryos at 90% epiboly. …”

Decreased invasiveness of WA-treated MDA-MB-231 cells is associated with changed expression of ECM remodeling and pro-inflammatory genes. by Katarzyna Szarc vel Szic (519230)

High level of cDC cytokine response to PAMPs decreased over the first year of life for all stimuli except LPS. by Brian A. Reikie (135894)

Child morbidity and mortality associated with alternative policy responses to the economic crisis in Brazil: A nationwide microsimulation study by Davide Rasella (632392)

“…With the maintenance of the levels of social protection provided by the BFP and ESF, in the most likely economic crisis scenario the U5MR is expected to be 8.57% (95% CI: 6.88%–10.24%) lower in 2030 than under fiscal austerity—a cumulative 19,732 (95% CI: 10,207–29,285) averted under-five deaths between 2017 and 2030. …”

Video_5_Maturation of Heterogeneity in Afferent Synapse Ultrastructure in the Mouse Cochlea.AVI by Shelby A. Payne (10987056)

Impact of 5HT stimulation on the plasma membrane density of truncated and mutant transporters. by Billow A. Ahmed (266461)

“…<p>CHO cells expressing truncated or mutant forms of transporter were either directly <i>(A and B)</i> or after stimulated with 100 μM 5HT <i>(C and D)</i> subjected to the cell surface biotinylation assays. …”

B-Raf^V600E melanoma cells acquire cancer phenotypes partly by increasing the expression levels of miR-10b. by Ila Datar (433874)

“…<p>(a) Upper panel: B-Raf^V600E knockdown decreases number of colonies in soft agar in sk-mel-28 cell line. …”

Dramatic Lockdown Fossil Fuel CO₂ Decrease Detected by Citizen Science-Supported Atmospheric Radiocarbon Observations by Jocelyn C. Turnbull (6083705)

“…This is consistent with sparse local traffic count information and a much larger decrease in traffic emissions than reported in global aggregate estimates of emission changes. …”

Natural disease history of the <i>dy^2J</i> mouse model of laminin α2 (merosin)-deficient congenital muscular dystrophy by S. Pasteuning-Vuhman (4348486)

“…<div><p>Merosin deficient congenital muscular dystrophy 1A (MDC1A) is a very rare autosomal recessive disorder caused by mutations in the <i>LAMA2</i> gene leading to severe and progressive muscle weakness and atrophy. …”

Relative <i>CHRNA5</i> promoter activity in BE(2)-C cells. by Glenn A. Doyle (209929)

“…The deletion (“d” in construct name) or normal (“i” in construct name) allele at rs3841324 is indicated by a red triangle or blue square, respectively. The deletion (“d”) constructs exhibited decreased activity (1.6–2.0-fold) relative to the normal (“i”) constructs. …”

Differentially expressed genes. by Bindu Ambaru (8775299)