Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…The Or42a OSN innervation volume with glial <i>5-HT</i>_<i>2A</i><i>R</i> OE is very significantly decreased in comparison to the control EB condition (<i>p</i> = 4.64 × 10⁻¹⁰). …”

Image_1_Enhanced lipid metabolism confers the immunosuppressive tumor microenvironment in CD5-positive non-MYC/BCL2 double expressor lymphoma.tiff by Meng-Ke Liu (10306315)

“…The addition of metformin significantly decreased the M2 proportion and the CD36 expression level in the coculture systems, indicating that metformin could target altered lipid metabolism and decrease M2 macrophages in DLBCL, especially in CD5+ non-DE lymphoma. …”

Continuous bioluminescence images after different days of transplanted Ad5-TGF transfected BMSCs into myocardial infarction rats (A). by Zhijun Pei (402179)

Degradation of a VX Analogue: First Organometallic Reagent To Promote Phosphonothioate Hydrolysis Through Selective P−S Bond Scission by Louis Y. Kuo (1915309)

“…We report the first case of a metal complex that degrades a neurotoxin mimic under extremely mild conditions (pH 6.8, room temperature). …”

ORC2 silencing enhanced PV replication in proliferating and differentiating CIN612-9E cells. by Marsha DeSmet (2513767)

“…<p>(A) ORC2 siRNA duplexes decreased ORC2 protein levels at a concentration of 15 or 5 nM after 48 h. …”

Image_5_RETRACTED: The Design, Characterizations, and Tumor Angiogenesis Inhibition of a Multi-Epitope Peptibody With bFGF/VEGFA.TIF by Ligang Zhang (830488)

Image_5_NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner.tif by Mégane Nascimento (5445878)

Temporal trend of ∑DDT levels in osprey eggs in different study areas and all areas combined (lower graph). by Matti Viluksela (321291)

“…∑DDT concentrations decreased significantly in the whole dataset (annual decrease 8.1%) and in all study areas (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.g015" target="_blank">Fig 15</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.t002" target="_blank">Table 2</a>). …”

Image5_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…Our search identified that miR-204-5p and miR-211-5p (miR-204/211), two broadly conserved miRNAs, share PDIA1 as a potential target. …”

Table_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_5_Living at the Edge: Increasing Stress for Plants 2–13 Years After the Retreat of a Tropical Glacier.DOCX by Fabien Anthelme (475650)

Image_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_3_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_5_Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study.XLSX by Bangjie Xu (18133135)

“…</p>Conclusion<p>There may exist a potential correlation between longer telomere length and a decreased likelihood of intracranial aneurysms within the European population. …”

Image_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Image_5_Birth Weight and Subsequent Risk of Total Leukemia and Acute Leukemia: A Systematic Review and Meta-Analysis.jpg by Hailuo Che (11470654)

Table_5_Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response.XLSX by Alok Khanduri (5999219)

“…These include miR-664, miR-2311, miR-2897, miR-484, miR-2440, miR-3533, miR-574, miR-210, miR-21-5p, and miR-30. miR-664 and miR-484 with proviral and antiviral activities, respectively, were upregulated in PPRV infected PBMCs. miR-210 that inhibits apoptosis was downregulated. miR-21-5p that decreases the sensitivity of cells to the antiviral activity of IFNs and miR-30b that inhibits antigen processing and presentation by primary macrophages were downregulated, indicative of a strong host response to PPRV infection. miR-21-5p was found to be inhibited on IPA upstream regulatory analysis of RNA-sequencing data. …”