HIF-2α directly binds to HREs in the OCT4, NANOG and SOX2 proximal promoters in hESCs cultured under hypoxia. by Raffaella Petruzzelli (409948)

“…<p>(A) ChIP analysis of HIF-2α binding a predicted HRE site in the proximal promoters of OCT4, NANOG, SOX2A and SOX2G on chromatin isolated from hESCs cultured either at 20% or 5% O₂. …”

Contribution of anti-CD4-BS antibodies in the overall neutralizing activities of plasmas collected longitudinally. by Iliyana Mikell (120166)

“…The color-coding is the same as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1001251#ppat-1001251-g005" target="_blank">Figure 5</a>. (--) the experiment was not performed because that particular plasma did not neutralize that particular virus; YPI: years post infection. …”

Influence of the environment on microsphere movement. by Valery Shalatonin (12666750)

“…A 5X objective was used. The microscope was focused on the PS microspheres situated in the upper part of the suspension, near the N pole side of the magnet. …”

Ca²⁺ sensitivity of the myofilaments was reduced by OVX. by Elias Fares (460284)

“…<p><b>A</b>. Shortening-[Ca²⁺] phase loop plots show that OVX caused a rightward shift in the descending phase of the loop, consistent with a decrease in myofilament Ca²⁺ sensitivity. …”

β-catenin regulates <i>Gata3</i> expression in the nephric duct. by David Grote (375350)

“…<p>(A, B) In situ hybridizations with a <i>Gata3</i> cRNA probe reveal a strong downregulation of <i>Gata3</i> expression in the nephric duct of E11.5 <i>Ctnnb1^ND−/−</i> embryos. …”

NAc DBS elicits distal network BOLD changes. by Emily J. Knight (222368)

“…<p>A–C) Areas of activation with left unilateral NAc stimulation at 5 V 130 Hz 500 µs (n = 7), normalized to a 3D pig brain template <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056640#pone.0056640-Saikali1" target="_blank">[44]</a> Significant activation q(FDR)<0.001 was observed in the anterior and dorsolateral prefrontal (red), insula (brown), parahippocampal (green) and cingulate cortex (blue). …”

Evaluation of quality of life in multiple sclerosis patients: impact of fatigue, anxiety and depression by Maria da Conceição Nascimento da Silva (8073284)

“…The Functional Determination Scale for Quality of Life in Multiple Sclerosis (DEFU), the Modified Fatigue Impact Scale (MFIS-BR), and the Hospital Anxiety (HADS-S) and Depression Scale (HADS-D) were applied. Patients with a Primary progressive clinical form presented worse perception of quality of life (66.90±3.47) when compared to the Secondary progressive (71.65±5.92) and Relapse-remitting (79.00±6.62) forms, with Significant difference (p<0.001). …”

Effect of shear, TFPI-coating concentration and FVIIa concentration in MDA-MB-231 adhesion to protein-immobilized channels under shear. by Sara P. Y. Che (718192)

“…</b> Microfluidic channels were immobilized with different concentrations of TFPI (5–100μg/mL), and MDA-MB-231 cells (pretreated with 10nM FVIIa and FX) were introduced at a shear of 0.35 and 0.60dyn/cm². …”

Entropy optimization and stability analysis in flow of quadratic radiative <i>Ag−MgO</i>/<i>water</i> hybrid micropolar nanofluid over an exponentially contracting permeable Riga s... by Gopinath Mandal (17767951)

PAK inhibition induces apoptosis via BAD and blocks the progression of BRAF mutant melanomas. by Rolando Ruiz (4285165)

“…<p>(A) FRAX597 inhibits PAK1 activation and induces apoptosis in BRAF^V600E melanoma cell lines. …”

The Pollen Organelle Membrane Proteome Reveals Highly Spatial−Temporal Dynamics during Germination and Tube Growth of Lily Pollen by Heidi Pertl (2339893)

“…As a first step in understanding the membrane-related dynamics during pollen grain germination and subsequent tube growth, the changes in protein abundance of membrane and membrane-associated proteins of 5 different membrane/organelle fractions were studied at physiologically important stages (0, 10, 30, 60, and 240 min) of <i>Lilium longiflorum</i> pollen <i>in vitro</i> culture. …”

The Pollen Organelle Membrane Proteome Reveals Highly Spatial−Temporal Dynamics during Germination and Tube Growth of Lily Pollen by Heidi Pertl (2339893)

“…As a first step in understanding the membrane-related dynamics during pollen grain germination and subsequent tube growth, the changes in protein abundance of membrane and membrane-associated proteins of 5 different membrane/organelle fractions were studied at physiologically important stages (0, 10, 30, 60, and 240 min) of <i>Lilium longiflorum</i> pollen <i>in vitro</i> culture. …”

Supplementary Material for: Early Crypt Formation Defects in the Uterine Epithelia of <b><i>Sox17</i></b> Heterozygous Mice by Hirate Y. (10274315)

“…Global transcriptional analysis revealed that the expression of Amphiregulin (<i>Areg</i>), a gene encoding a heparin-binding epidermal growth factor receptor ligand, was decreased drastically in <i>Sox17</i>^+/− uterine epithelia. …”

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy by Maria Xilouri (264240)

“…In both PC12 and SH-SY5Y cycling cells, induction of A53T ASYN evoked a significant decrease in lysosomal degradation, largely due to CMA impairment. …”

Distinct context-specific interactions regulate <i>pntP2</i> transcription across the eye field. by Chudong Wu (9708019)

“…In <i>pnt</i>^<i>p2</i> discs (D) relative to wild type (C), an increased and broader peak of <i>pntP2</i> transcripts was detected in and immediately posterior to the MF while a decrease was seen in the posterior half of the disc. …”

/ target insertion profile library by Richard J Gradman (40127)

Practical facility-level approaches to reduce the malaria test positivity rate in Oyo State, Nigeria dataset.csv by Esther Oluwayemisi Ayandipo (18777193)

Image1_An ex-vivo model for the biomechanical assessment of cement discoplasty.PDF by Salim Ghandour (13582540)

“…A decrease of 51.5% in segment stiffness was found after injury, as expected. …”

Computational modeling results. by Jaejoong Kim (11668928)

“…</b> In the escaping behavior, compared to the hunting behavior, <i>θ</i>, the time step of computation was shorter (Escape vs. Hunt: 10.9 vs. 15.6 in experiment 1; 11.4 vs. 15.5 in experiment 2; all <i>p</i> < 0.001 in mixed-effect regression) and the <i>τ</i> was lower (Escape vs. …”

Reduced insulin/IGF-1-like signaling protects against age-dependent protein insolubility and aggregation. by Della C. David (244107)

“…<p>(A) Sypro Ruby staining revealed a decrease in overall age-dependent protein insolubility in <i>gon-2(−)</i>/gonad-less animals treated with <i>daf-2</i> RNAi compared to control RNAi (1.6-fold compared to a 3.6-fold increase with age, quantified in the red outlined areas). …”