Image2_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.TIF by Kai Wang (21246)

“…Finally, we observed downregulation of calcium handling genes and upregulation of NPPB in R403Q vs. WT ECTs. In an HCM phenotype prevention experiment, ECTs were treated for 5-weeks with 250 nM mavacamten or a vehicle control. …”

Table1_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.DOCX by Kai Wang (21246)

“…Finally, we observed downregulation of calcium handling genes and upregulation of NPPB in R403Q vs. WT ECTs. In an HCM phenotype prevention experiment, ECTs were treated for 5-weeks with 250 nM mavacamten or a vehicle control. …”

In situ ruminal degradability of silages of elephant grass additivated with corn bran and inoculation of autochthonous microbiota by Higor Fábio Carvalho BEZERRA (6126950)

“…<p></p><p>This study aimed to evaluate the in situ degradability of dry matter, crude protein and neutral detergent fiber of elephant grass silage with corn bran and inoculation of autochthonous microbiota. For the silages used a 4 x 2 factorial arrangement (four levels of corn bran - 0, 5, 10 and 20dag/kg x with and without inoculation) and five replications, in a completely randomized design. …”

Diversity of ferns and lycophytes in Brazil by Jefferson Prado (4695187)

“…The results show 1,253 species: 1,111 of ferns and 142 of lycophytes. This number is 6.5% higher than the previous one (1,176 spp.). The percentage of endemic species decreased from 38.2% to 36.7%. …”

Performance of sheep fed forage cactus with total water restriction by Alma Violeta CORDOVA-TORRES (4829148)

“…Variables were analyzed using Tukey and Dunnett's test at 5% with PROC GLM in SAS software. Voluntary water intake and dry matter intake (DMI) decreased with the inclusion of forage cactus; however, preformed water intake and total water intake increased with the inclusion of forage cactus. …”

Comparison of Invasive Blood Pressure Measurements from the Caudal Ventral Artery and the Femoral Artery in Male Adult SD and Wistar Rats by Ying Wang (11406)

“…The overall mean gradient and the mean gradient under a steady hemodynamic state were 4.9±3.7 mm Hg and 5.5±2.5 mm Hg, respectively. …”

Morphological and epigenetic changes of HFFs after inhibitor and/or hESC extract treatment. by Jinnuo Han (243503)

“…(B) Immunoblotting analysis shows decrease in 5-methyl cytosine and increase in H3K9 acetylation levels after combined treatment. …”

Effect of 10 μM 8-cyclopentyltheophylline (8-CPT) on evoked EPSP depression produced by <i>in vitro</i> ischemia. by Shirin Jalini (2551054)

“…<p>Some OGD-induced decrease in fEPSP persists in the presence of an A₁-antagonist. 8-CPT reduced the OGD-induced percentage change in fEPSPs relative to control after 2 min (n = 5, <i>p</i><0.0003) and 4 min (n = 5, <i>p</i><0.005), but not after 6 min (n = 6, <i>p</i>>0.14) of OGD. * p < 0.05, Student t-test</p>…”

Analysis of bone marrow B cell development in Gfi1^−/− mice. by Chozhavendan Rathinam (273627)

“…Flow cytometry was done in pooled cell suspensions (n = 5 mice). Shown is a representative experiment of 5.…”

WFA inhibits STS cell growth. by Guy Lahat (250220)

“…<p><i>A)</i> WFA treatment (1 µM/24 h) results in marked morphological changes, including cell-rounding and nuclear condensation, in STS cells; <i>B)</i> MTS assays demonstrate a WFA-induced, dose-dependent decrease in STS cell growth; <i>C)</i> WFA (0.5 µM/24 h) markedly inhibits STS cell colony formation capacity measured after ten days; <i>D)</i> WFA (0.5 µM/24 h) abrogates STS cell anchorage independent growth measured after three weeks. …”

Relationship between reward incentive and likelihood precision under different levels of prior precision and information cost. by John G. Mikhael (3098307)

“…(B) Increases in <i>κ</i> shift the function to the right and decrease the slope. For illustration, we have fixed <i>κ</i> = 0.5 and λ₀ = 0.5 in (A) and (B), respectively.…”

Immmocytochemistry of DMT1−IRE, DMT1+IRE, Fpn1 and TfR1 proteins in cortical neurons. by Fang Du (232423)

“…<p>Cells were treated with L-DOPA (0, 1, 5, 10, 100, 200 µM) in DMEM+5%FBS for 16 hours and then immunostained for DMT1−IRE (A), DMT1+IRE (B), Fpn1 (C) or TfR1 (D) antibodies. …”

Intravenous self-administration of cocaine is not altered by bilateral PPTg cholinergic cell loss. by Stephan Steidl (339615)

“…All rats showed a decrease in cocaine intake on the first post-lesion testing day that returned to pre-lesion baseline levels by the third post-lesion testing day. …”

Data from The impact of human disturbances on the regeneration layer of tropical rainforests by Ricard Arasa-Gisbert (20308659)

“…We excluded studies reporting effects on the regeneration community but that used too wide ranges of size (e.g., diameter) classes (e.g., studies that examined together all plants < 10 cm DBH), because such grouping of information could prevent the proper identification of specific disturbance effects on each life cycle category. (4) Studies focused on vines and/or herbs were excluded because these life forms have different environmental requirements than trees and palms. Finally, (5) the studies were required to report the mean, sample size, and a dispersion measure of the dependent variables (i.e. standard error, standard deviation) or to present figures from which these metrics could be extracted. …”

Image_1_Smaller left ventricular end-systolic diameter and lower ejection fraction at baseline associated with greater ejection fraction improvement after revascularization among p... by Shaoping Wang (8917481)

“…</p>Results<p>A total of 939 patients were identified. A total of 549 (58.5%) had EF improved. …”

Loss of <i>Smad4</i> led to excessive proliferation of the retina cells at early development and abundant apoptosis later as assessed by pulse BrDU labeling and staining as well as... by Jing Li (10611)

“…<p><b>(A-D)</b> Results of BrDU labeling followed by immunostaining were shown in <i>Smad4</i>-cKO mice and control mice at the nasal paracentral zone of P0 and P5. …”

Longitudinal course of circulating donor-specific T-cell precursor frequencies in LTx-recipients. by Özlem Tapirdamaz (358220)

“…Donor-derived and 3^rd party-derived stimulator cells differed on the average at 1.8 HLA-AB loci and 1.5 HLA-DR loci. A. Numbers of T-cell precursors responding to donor-derived CD40-B cells increased significantly 1 week after transplantation in all T-cell subsets, followed by a decrease to values below pre-transplant levels. …”

Tn-seq screen for new sporulation genes. by Alexander J. Meeske (843722)

“…<b>(C)</b> Scatterplot showing the extent of decrease in transposon insertions in all genes at T5. …”

Selective inhibition of EBV-positive cells to PLOD1 depletion or inhibition by 2-DP. by Jayaraju Dheekollu (56109)

“…<p><b>A)</b> Flow cytometry analysis of cell viability using propidium iodide (PI, y-axis) and Annexin V (x-axis) for DG75, BJAB, MutuI, Raji, B95.8LCL transduced with control shRNA or PLOD1 shRNA for 5 days. …”

Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate by KÉSIA ZANUZO (10365843)

“…In MSG-obese rats, there was such as a decrease in the diameter of the, glomerular tuft, Bowman’s capsule, Bowman’s space areas, and renal cortical thickness, compared to the control group. …”