Presentation_1_Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target.pptx by Sagar Sanjiv Desai (11634628)

“…Modelling of the IRAK1 mutation showed a decrease in its binding to known IRAK1 inhibitors.…”

Effects of hyperosmotic stress on regulatory enzymes associated with cytoskeletal remodeling. by Rodrigo A. Silva (703576)

“…Despite the increase in protein levels of total Src kinase, a significant decrease in the phosphorylation of Y416 located on the activation loop of the kinase, and an increase of Y527, which corresponds to its inhibitory site, occur. …”

MiR-150 expression promotes myeloid differentiation of primary BC CML patient cells. by Valerie A. Morris (462679)

“…(A) CD34+ cells from two BC CML patients were assessed for CD34 and CD11b expression 7 days after transduction in the presence of rhSCF, rhIL3, rhIL6, rhGCSF, and rhGMCSF (50 ng/ml each). …”

LMH 87 down-regulates surface c-MET and inhibits tumor cell growth. by Sameer A. Greenall (172514)

“…Data is presented as the cell index normalized to 21 h ± SEM, the time point when antibody was added. Both the 50 and 100 µg/ml treatments caused a significant decrease (<i>p</i>&lt;0.05) in cell index compared to vehicle control. …”

Additional file 3 of C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties by Monique van Es-Remers (13895294)

“…In this assay C. elegans was exposed to different concentrations (5, 50 and 100 μg/mL) of the Non-Polar Fractions both in carboxylated (NPFdec) and non-decarboxylated (NPF) form. …”

Evolution of a tumour spheroid and associated variables in time, including the tumour cell, oxygen, free and bound polymersome concentrations for <i>n</i> = 5. by Hannah West (11172998)

“…Initially growth occurs with no free polymersomes on the tumour surface up to a radius of 175<i>μm</i>, then we introduce polymersomes by setting <i>V</i>_∞ = 10 when 40 ≤ <i>t</i> ≤ 50 days. …”

Microwave ablation combined with anti-PD-1/CTLA-4 therapy induces an antitumor immune response to renal cell carcinoma in a murine model by Run-Qi Guo (13266491)

“…MWA treatment increased PD-L1/PD-1 expression; however, after the combination treatment with ICI, PD-L1/PD-1 expression was decreased. According to the rechallenge test, mice (16.7%) in the MWA group, ICI group (50%), and MWA+ICI group (66.7%) exhibited successful tumor rejection, whereas no mice in the control group exhibited the capability of tumor rejection. …”

Loss of protein stability in the absence of myotubularin-MTMR12 interactions. by Vandana A. Gupta (142475)

“…<p>(A) Knockdown of <i>mtmr12</i> resulted in a strong decrease of myotubularin protein in <i>mtmr12</i> morphant zebrafish at 3 dpf by western blotting. …”

Zn²⁺ is required for the enhancement of NMDAR fEPSPS which requires NR2B-containing NMDARs and activation of Src family kinases (SFK). by John A. Sullivan (6018725)

“…Statistical data are presented as mean ± SEM.</p>…”

DataSheet_1_Toxicity, baseline of susceptibility, detoxifying mechanism and sublethal effects of chlorogenic acid, a potential botanical insecticide, on Bemisia tabaci.docx by Ran Wang (169166)

“…<p>Bemisia tabaci is a threat to agriculture worldwide because of its potential to cause devastating damage to crops. …”

Effect of a roadblock on ParB2-mediated stimulation of <i>oriII</i> activity in <b><i>E. coli</i></b>. by Tatiana Venkova-Canova (424756)

“…For determining generation times, the cultures were diluted 50× and grown to early log phase. The generation times are from five different cultures, and they decreased in the presence of IPTG in all cases, but less so under the condition RepA was expected to bind to P1 iterons and create roadblock (Table row #4). …”

A Small-Molecule Inhibitor of <em>T. gondii</em> Motility Induces the Posttranslational Modification of Myosin Light Chain-1 and Inhibits Myosin Motor Activity by Aoife T. Heaslip (207534)

“…<div><p><em>Toxoplasma gondii</em> is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional Class XIV myosin; TgMLC1, a myosin light chain; and two membrane-associated proteins, TgGAP45 and TgGAP50. …”

Table1_Ocean warming enhances the competitive advantage of Ulva prolifera over a golden tide alga, Sargassum horneri under eutrophication.docx by Hailong Wu (84632)

“…In monocultures, the growth of U. prolifera and S. horneri, along with pigment concentrations and photosynthesis, increased with rising temperature, reaching a plateau at 15 - 25°C. However, when the temperature increased to 30°C, the growth of U. prolifera and S. horneri decreased abruptly, with S. horneri even suffering death. …”

A quantitative image-based screen identified host factors that affect <i>L</i>. <i>monocytogenes</i> invasion and cell-to-cell spread. by Michelle Rengarajan (2723380)

“…<p><b>(A</b>) Illustration of hypothetical phenotypes that can be identified in the screen. …”

Data_Sheet_1_Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials.docx by Gengbin Chen (13172334)

“…</p>Methods<p>The PubMed, Web of Science, and Embase databases were searched for articles published in the English language, from inception to December 8, 2022.</p>Results<p>A total of 9,810 independent records generated 50 high-quality randomized controlled trials on 119 biomarkers. …”

Data_Sheet_1_Trends in the Prevalence of Hypertensive Heart Disease in China From 1990 to 2019: A Joinpoint and Age–Period–Cohort Analysis.docx by Dan Xu (138152)

“…The age effect analysis showed an increase in HHD prevalence from 50 to 94 years in both males and females, the period effect analysis showed a slight increase in HHD prevalence from 2009 to 2019 in females, and the cohort effect analysis showed a consistent decline in HHD prevalence from earlier to later birth cohorts in both males and females.…”

Table 1_Influence of age and sex on the diagnostic accuracy of pleural fluid carcinoembryonic antigen for malignant pleural effusion: a post hoc analysis.docx by Dan-Ni Yang (17642947)

“…</p>Methods<p>We enrolled participants from a prospective cohort (SIMPLE) and a retrospective cohort (BUFF). …”

Effect of <i>Campomanesia adamantium</i> peel extract on cGMP levels in T84 cells. by Caroline Honaiser Lescano (3232635)

An Example of a Gene Network that Is Largely Contained within an LD Domain Located between 167.2 and 174.2 Mb on Mouse Chromosome 1 by Petko M Petkov (10685)

“…<i>Pex19, Pea15, Casq1,</i> and <i>Tagln2</i> are located within 400 kb. Myc decreases the expression of <i>Pex19</i> [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0010033#pgen-0010033-b26" target="_blank">26</a>] and <i>Tagln2</i> [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0010033#pgen-0010033-b50" target="_blank">50</a>]. …”

Data_Sheet_1_Impact of COVID-19 Outbreak on the Gynecological Outpatients HPV Infection Rate in Wuhan, China: A Retrospective Observational Study.pdf by Hang Liu (3694)

“…</p>Results<p>There was a 50% drop in HPV screening visits and a 10% drop in HPV infection rates throughout the pandemic when compared with the numbers collected before the pandemic. …”