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19861
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19862
Comparison of MSH4 and RNF212 dynamics in WT and <i>Cdk2</i><sup><i>T160A</i></sup> spermatocytes.
Published 2020“…In early-pachytene WT and <i>Cdk2</i><sup><i>T160A</i></sup> spermatocytes, MSH4 foci can be observed along the length of paired axes (A and C, insets I–II and V–VI). …”
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19863
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19864
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19865
Table_1_Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs.docx
Published 2019“…The pattern of dysbiosis and altered BA composition is similar to that seen in humans with Type 2 DM. The dog represents a novel large animal model for advancing translational medicine research efforts (e.g., investigating pathogenesis and therapeutics) in DM affecting humans.…”
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19866
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19867
Proposing model for the interplay between E-cadherin, IR/IGF-IR, and bisecting GlcNAc <i>N</i>-glycans on the stabilization of both cell-cell adhesion and epithelial-like phenotype...
Published 2013“…Stimulation with insulin or IGF-I activates IR/IGF-IR signaling and downstream protein ERK 1/2, promoting a decreased expression of bisecting GlcNAc structures in general and specifically on E-cadherin which was previously shown to destabilize cell-cell adhesion [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081579#B18" target="_blank">18</a>], leading to an invasive phenotype. …”
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19868
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19869
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19870
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19871
DataSheet1_The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism.docx
Published 2024“…The IC<sub>50</sub> values of telmisartan and carvedilol in CYP3A4.1 were 6.68 ± 1.76 μM and 0.60 ± 0.25 μM, respectively, whereas in CYP3A4.12, the IC<sub>50</sub> exceeded 100 μM. …”
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19872
Two-wave induction of the phosphate starvation response.
Published 2017“…Genes induced by Pho4 include high-affinity transporters (e.g., <i>PHO84</i>) and an inhibitor of low-affinity transporters (<i>SPL2</i>), genes involved in phosphate mobilization in and out of vacuole storage as PolyP (e.g., <i>PHM3</i>), and phosphatases, which scavenge phosphate from molecules inside or outside the cell. …”
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19873
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19874
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19875
<i>ACVR2</i> promoter hypermethylation and LOH in colon cancer specimens and the MSS HT29 cell line and correlation of <i>ACVR2</i> promoter hypermethylation and loss of <i>ACVR2</...
Published 2009“…<p>A) ACVR2 promoter with map of positioning of MSP primers B) Using a CpG islands search program, we identified the CpG islands within the <i>ACVR2</i> promoter based upon following stringent criteria: ∼CG percentage>55%; observed CpG/expected CpG >0.65; length >500 bp. …”
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19876
Analysis of DRD1 and DRD2 signalling upon dopamine treatment in SH-SY5Y-DRD1 or -DRD2 stable lines untransduced or transduced by WT or G2019S LRRK2.
Published 2017“…<p><b>(A)</b> Cells stably expressing FLAG-tagged DRD1 were transduced by the different LRRK2 isoforms. 48h after transduction the cell were treated for different time points (15', 30', 60') by dopamine. …”
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19877
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19878
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19879
Ca<sup>2+</sup> sensitivity of the myofilaments was reduced by OVX.
Published 2013“…Maximum actomyosin MgATPase activity was similar in both groups. <b>E</b>,<b>F</b>. OVX increased mean EC<sub>50</sub> values compared to sham hearts but had no effect on the Hill coefficient (n=25 sham and 26 OVX myocytes for panel B; n=5 sham and 4 OVX hearts for actomyosin MgATPase assay; *p<0.05; Panel C was analyzed with a two-way ANOVA; main factors of free Ca<sup>2+</sup> and OVX were significant; other data were analyzed with a t-test; *denotes significant differences).…”
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19880
Study Data.
Published 2025“…It has also been hypothesized that the bradycardia and rare instances of cardiac arrest occurring after the use of sugammadex may be due to a transient decrease in circulating corticosteroids, causing a temporary ‘mini Addisonian crisis.’ …”