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point decrease » point increase (Expand Search)
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e decrease » a decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
_ decrease » _ decreased (Expand Search)
point decrease » point increase (Expand Search)
mean decrease » a decrease (Expand Search)
e decrease » a decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
_ decrease » _ decreased (Expand Search)
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NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways.
Published 2020“…Drk/Grb2 and MAPK, two positive components of the EGFR signaling pathway are targeted for degradation by the Arg/N-end rule pathway and E3 ubiquitin ligase Ubr4 while PP2AC, a negative regulator of EGFR signaling pathway, is targeted for degradation by the Ac/N-end rule pathway E3 ubiquitin ligase Cnot4. …”
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NatB-inactivation decreased Drk levels through its N-terminal sequences, which was regulated by the N-end rule E3 ubiquitin ligase POE/UBR4.
Published 2020“…Ubr4/POE RNAi restored the Drk level in <i>psid-D1</i> clones (I) but did not influence the level of PP2AC (J), suggesting a specific effect of Ubr4 on Drk but not PP2AC degradation.…”
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AKT inhibition decreases neuroblast populations.
Published 2012“…<p>(<b>A</b>) SOX2 expression upon PI3K-AKT inhibition. Otic vesicles were isolated from HH18 chicken embryos, made quiescent and cultured for 20 h in serum-free culture medium without additions (0S, a) or in the presence of IGF-I (10 nM, b), LY294002 (LY, 25 µM, c) or AKTi VIII (AKTi, 50 µM, d). …”
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