KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity by Mengyu Liu (2890397)

“…</p> <p><b>Abbreviations</b>: 3-MA: 3-methyladenine; AAV: adeno-associated virus; ACTB: actin beta; AGC: automatic gain control; ATG: autophagy-related; ATP6V0D1: ATPase H⁺ transporting lysosomal V0 subunit D1; ATP6V1E1: ATPase H⁺ transporting lysosomal V1 subunit E1; CA: cornu ammonis; CQ: chloroquine; CTSB: cathepsin B; CTSD: cathepsin D; DCTN1: dynactin subunit 1; DG: dentate gyrus; DYNLL1: dynein light chain LC8-type 1; FBS: fetal bovine serum; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; IPA: Ingenuity Pathway Analysis; KEGG: Kyoto Encyclopedia of Genes and Genomes; KIF5A: kinesin family member 5A; LAMP: lysosomal-associated membrane protein; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; NBR1: NBR1 autophagy cargo receptor; OPTN: optineurin; PBS: phosphate-buffered saline; PFA: paraformaldehyde; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PRM: parallel reaction monitoring; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; SYP: synaptophysin; TAX1BP1: Tax1 binding protein 1; TMT: trimethyltin chloride; TUB: tubulin.…”

Scatter plot of differential gene expression values upon E/R KD in two cell lines. by Gerhard Fuka (200028)

“…<p>Each dot represents the mean regulation value (log2-fold change of E/R-repressed versus control cells) of three and two replicas, for REH and AT-2 cell lines, respectively. x-axis: REH cell line, y-axis: AT-2 cell line. …”

Geographic distribution by group. by Megayn E. Lewandowski (18599144)

“…<div><p>Background</p><p>The COVID-19 pandemic disrupted lives on a massive scale. While the pandemic appeared to worsen mental health outcomes broadly, its effects on alcohol/substance use and recovery are unclear. …”

Demographics. by Megayn E. Lewandowski (18599144)

“…<div><p>Background</p><p>The COVID-19 pandemic disrupted lives on a massive scale. While the pandemic appeared to worsen mental health outcomes broadly, its effects on alcohol/substance use and recovery are unclear. …”

Self-reported life events. by Megayn E. Lewandowski (18599144)

“…<div><p>Background</p><p>The COVID-19 pandemic disrupted lives on a massive scale. While the pandemic appeared to worsen mental health outcomes broadly, its effects on alcohol/substance use and recovery are unclear. …”

AZ3451 and PD98059 reduced the intestinal IIL and adult worm burden at 12 h and 5 d post infection. by Lu Lu Han (4759488)

Adverse events ^a. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Image 5_The CYP4/20-HETE/GPR75 axis in the progression metabolic dysfunction-associated steatosis liver disease (MASLD) to chronic liver disease.tiff by James P. Hardwick (20634155)

Image 5_The CYP4/20-HETE/GRP75 axis in the progression metabolic dysfunction-associated steatosis liver disease (MASLD) to chronic liver disease.tiff by James P. Hardwick (20634155)

Effects of As₂O₃ on A431 cell EGFR expression. by Lingbo Zhang (132359)

“…Interestingly, cell numbers decreased as the arsenic trioxide concentration increased from 0 µM to 5 µM in both fluorescent and immunostained images, indicating that As₂O₃ induced a dose-dependent inhibition on tumor cell proliferation as previously reported <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046255#pone.0046255-Kumar1" target="_blank">[31]</a>.…”

Change in GHG emissions by enterprise for $0 to $60/tCO2e GHG price scenarios. by Fraser J. Morgan (743027)

“…<p>For all scenarios, the total net GHG emissions are estimated to decrease over time, including the $0/tCO2e baseline. …”

Boxplots of the means (A) and variances (B) for the 33 spikes on all arrays in the experiment after outlier removal by Mark J Dunning (41382)

Live imaging of <i>pRPS5A</i>::<i>TagRFP</i>:<i>TUB4</i> tubulin marker during regular meiotic divisions and two postmeiotic spindle reassembly cycles in smg7-6 mutants. by Claudio Capitao (5933654)

Environmental enrichment reverses the social isolation induced changes in the expression of BDNF in hippocampus. by Swamynathan Sowndharya (17816808)

Image_1_Eph-ephrin Signaling Affects Eye Lens Fiber Cell Intracellular Voltage and Membrane Conductance.TIF by Catherine Cheng (114496)

“…Recent studies have revealed that disruption of Eph-ephrin signaling, in particular the receptor EphA2 and the ligand ephrin-A5, in humans and mice lead to congenital and age-related cataracts. …”

Feijoa F3 inhibits NF-κB activity in A. MEF cells and B. MEF Atg5^-/- cells. by Noha Ahmed Nasef (760610)

Simulated effects of increased pCREB combined with decreased pCaMKIIα on time courses of molecular pathways and synaptic weight W after IA training. by Yili Zhang (540283)

“…(B) Example of dynamics of BDNF protein/mRNA (B1-2), C/EBPβ protein (B3), pCREB (B4), pCaMKIIα (B5), Sin3a binding (B6), MeCP2 binding (B7), HDAC2 binding (B8), and W (B9), with the standard parameter values in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010239#pcbi.1010239.t001" target="_blank">Table 1</a> (black dashed) or with <i>k</i>_{<i>basalp_creb</i>} increased by ~50% and <i>k</i>_{<i>basalp_CaMKII</i>} decreased by ~50% from control combined with higher binding levels of MeCP2, Sin3a and HDAC2 (blue) to simulate IA conditioning in infant rats. …”

Distribution of NGS reads to the reference sequences (100 kb-bin size) on chromosome 3, 4 and 5 for four M1 mutant sectors [5–3 (blue squares), 13–2 (gray triangles), 15–4 (golden... by Satoshi Kitamura (3226803)

“…In addition to the large deletions found by the mutation-calling algorithms (indicated by solid arrows), four additional regions (dotted arrows) showed decrease of the reads. For the regions of chromosome 5 in 5–3 (blue dotted arrow) and chromosome 3 in 15–4 (golden dotted arrow), probable junctions could not be detected from our NGS data (labeled as “undetermined”). …”

Image_5_Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1.TIF by Li Zhang (8200)

(a) Changes of exchangeable Ca²⁺ content during acification of black soil. (b) Changes of exchangeable Mg²⁺ content during acification of black soil. The cont... by Xiaoxu Zhu (11764430)