PIN1 silencing leads to decreases in the protein levels of HIF-1α. by Hyeong-jun Han (846566)

“…E) ATRA decreases the expression of HIF-1α and PIN1 in HCT116/5xHRE-ODD-luc cells in dose-dependent manner. …”

Expression of a 65kDa isoform of eIF2Bε leads to a global decrease in protein synthesis. by Lauren K. Brady (4479244)

eIF5a interacts with Mfn1 and preserves mitochondrial integrity. by Dong Ma (584680)

Subjects:

Effect of eIF5a and Mfn1 expression on mitochondrial morphology. by Dong Ma (584680)

Subjects:

eIF5a affects the expression of mitochondrial dynamics–related genes. by Dong Ma (584680)

Subjects:

Cardiac function assessed by echocardiography in Ang II–infused young (3 months) or old (18 months) WT and smcKlf5^−/− mice. by Dong Ma (584680)

Subjects:

Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom <i>Thalassiosira pseudonana</i> - Fig 2 by Johanna A. L. Goldman (7372724)

Increasing temperature decreases oxygen concentration and decreasing oxygen content decreases neuronal excitability. by Yuguo Yu (172221)

“…Increasing temperature can dramatically decrease oxygen levels. B. Response of layer 2/3 pyramidal cells (n = 5) to the intracellular injection of a depolarizing current pulse (200 pA, 500 ms) at different temperatures (same experiments as in A). …”

Bioluminescence decreases with aging in transgenic mice. by Sarah E. Mailhiot (766685)

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

Representative TUNEL- and DAPI-stained sections from the abdominal aortas of young and old WT and smcKlf5^−/− mice following 28 days of Ang II infusion. by Dong Ma (584680)

Subjects:

Klf5 activates the transcription of the eIF5a gene through direct binding to its promoter. by Dong Ma (584680)

Subjects:

NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways. by Zhentao Sheng (107495)

“…Drk/Grb2 and MAPK, two positive components of the EGFR signaling pathway are targeted for degradation by the Arg/N-end rule pathway and E3 ubiquitin ligase Ubr4 while PP2AC, a negative regulator of EGFR signaling pathway, is targeted for degradation by the Ac/N-end rule pathway E3 ubiquitin ligase Cnot4. …”

<i>In vivo</i> RCAS-hLPL infection decreases high triglyceride levels in hypertriglyceridemic mice. by Katherine E. Gadek (3276996)

2-ME decreases blood pressure in Sprague Dawley rats. by Weiyu Chen (2216251)

MOLM14 cells incubated with Eltrombopag for 6 hours show higher expression of stress response genes. by Anna Kalota (7415)

Subjects:

Raw data used to generate the graphs shown in Figs 1B, 1E, 2B, 3B, 4B and 5A–5C of representative experiments from three independent biological repeats. by Timilehin Faboro (20175963)

Subjects:

ANG II treatment leads to decreased contractile function. by Renita E. Horton (847891)

“…(E) Representative stress traces generated from x-projections of films (F) ANG II treatment leads to a decrease in contractile stress generation. …”

Binding of <i>PC3/Tis21</i> to the <i>Id3</i> promoter and corresponding decrease of <i>Id3</i> mRNA. by Stefano Farioli-Vecchioli (256006)

“…<p>(<b>A–D</b>) A PC12 cell line carrying an inducible <i>PC3</i> (rat) cDNA under control of the tet-off system (i.e., a tetracycline responsive element TRE-PC3, activated by a tetracycline-regulated transactivator, CMV-tTA, in the absence of doxycycline) was used to analyze the binding of <i>PC3</i> to the <i>Id3</i> promoter, by chromatin immunoprecipitation (ChIP). …”

Activation of apoptotic pathway in AML cells by Eltrombopag. by Anna Kalota (7415)

Subjects: