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GluN2A(D731N) decreases channel open probability.
Published 2017“…The receptors were activated by EC<sub>50</sub> concentrations of glutamate with saturating concentration (100 μM) of glycine at holding potential of -40 mV. The di-heteromeric mutant (2A-D731N) and tri-heteromeric receptors with two-copies of the mutant subunit (D731N/D731N) showed a prolonged inhibition rate, reflecting a decreased channel open probability. …”
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643
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647
Pharmacologically induced torpor by 5′-AMP does not decrease platelet count despite decreased body temperature.
Published 2014“…<p>A) Pharmacologically induced torpor by 5′-AMP in mice does not decrease platelet count during torpor and shows an increase upon arousal. …”
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648
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659
T0 treatment significantly decreased soluble Aβ oligomers, but not amyloid plaque pathology in APP/E4/Abca1<sup>+/-</sup> mice.
Published 2017“…N = 5–6 mice per group. N.S., not significant. <b>E,</b> T0 treatment significantly decreases Aβ oligomers in APP/E4/Abca1<sup>+/-</sup> mice. …”
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660