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Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors
Published 2017“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”
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724
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Klf5 activates the transcription of the eIF5a gene through direct binding to its promoter.
Published 2020Subjects: -
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728
Decreased RNA Polymerase II Occupancy at Promoters and Coding Regions of Genes Down-Regulated in SCA7 Mice
Published 2013“…<p>(A–F) ChIP assays were performed using formaldehyde-fixed chromatin extracts of retina from 2-mo-old control (WT or R7N; dark grey) and R7E (light grey) mice. …”
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729
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Cytotoxic effect of Eltrombopag on AML cells is dependent on dose and serum concentration.
Published 2015Subjects: -
740
Eltrombopag Does Not Significantly Affect Mitochondria Function and ATP Production.
Published 2015Subjects: