Image_4_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_1_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_3_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Comparing gene dysregulation in peripheral blood of MMD with other vascular disorders by GSEA. by Xing Peng (3874045)

“…In each enrichment plot, genes are ranked according to log2 fold change value (i.e. from the most up-regulated to the most down-regulated genes between MMD patients and healthy controls). …”

Prediction performance of PV as genetic heterogeneity increases across populations (Simulation Study II). by Xiaoxuan Xia (8186667)

“…<p><b>Legend</b>: With PV: Prediction model is the Prism Vote with the DPR base controlling top 10 PCs; Without PV (the reference method): DPR controlling for the top 10 PCs only. <b>(A)</b> Heritability = 0.2; <b>(B)</b> Heritability = 0.5; <b>(C)</b> Heritability = 0.8. …”

EGCG prevents HMGB1 accumulation/clustering on macrophage cell surface. by Wei Li (7081)

Aqueous Hafnium Sulfate Chemistry: Structures of Crystalline Precipitates by Ali Kalaji (1734037)

Conformational Mobility Analysis of the ErbB Kinases. by Kevin A. James (666304)

“…<p>Conformational mobility mapping of ErbB2-WT in the inactive Cdk/Src-IF3 form (left upper panel), ErbB3-WT in the inactive Cdk/Src-IF1 conformation (right upper panel), ErbB4-WT in the Cdk/Src-IF1 form (left lower panel) and the active form (right lower panel). …”

Proteomic and Transcriptional Analysis of Interaction between Oral Microbiota Porphyromonas gingivalis and Streptococcus oralis by Kazuhiko Maeda (1294320)

Allometric relationships between above-ground biomass increment and stand characteristics for crimean pine in Taşköprü, Turkey by Fadime Sağlam (15430928)

“…In this study, the changes of increments of the above-ground total, stem and branch biomasses depending on stand characteristics (i.e., stand age, stand density, and site index) were investigated, and these relations were modeled for Crimean pine (Pinus nigra J.F.Arnold subsp. pallasiana (Lamb.) …”

Gelsolin or cofilin overexpression normalizes bioenergetics in α-synuclein transgenic flies. by Souvarish Sarkar (8382513)

“…<p>(A-G) Metabolic profiling of whole <i>Drosophila</i> brains in Seahorse XFe96-well culture microplates (Agilent) reveals decreased oxygen consumption rate (OCR, A), extracellular acidification rate (ECAR, B), proton efflux rate (PER, C), non-mitochondrial respiration (D), basal respiration (E), maximal respiration (F), and proton leak (G) mediated by α-synuclein expression, which is substantially rescued by gelsolin or cofilin overexpression. …”

Metabolite Profiles Correlate Closely with Neurobehavioral Function in Experimental Spinal Cord Injury in Rats by Yusuke Fujieda (143848)

“…A dynamic inflammatory response consisting of elevated levels of prostaglandin E2 and palmitoyl ethanolamide as well as pro- and anti-inflammatory polyunsaturated fatty acids was observed. …”

Effect of human mutant-type FRMD7 proteins on the activation of Rac1 signaling. by Jiali Pu (445199)

“…Extracts of HEK293T cells transfected with two missense mutant-type FRMD7 (c.781C>G, C781, c.886G>C, G886) showed decreased amounts of GTP-Rac1 compared with the wild-type FRMD7. …”

<i>In</i><i>vitro</i> characterization of SGSCs. by Sabine Nagel (476531)

“…Nuclei were stained with DAPI. Scale bars 100 μm. E) Analysis of cytokine secretion via membrane-based array system of SGSCs grown on cell culture plastic. …”

CD138⁺ MMC/OSB N-cadherin mediated interactions. by Wenting Zhang (342162)

“…<p>Data presented is the response of patient sample #4 and it is representative of repeated experiments conducted using a total of 2 different patient samples (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125995#pone.0125995.t001" target="_blank">Table 1</a>). …”

Splenomegaly and infection kinetics of the male reproductive tract during acute infection with Asian genotype ZIKV strains. by Erin M. McDonald (833291)

“…P-values were determined by 2way ANOVA. *, p<0.05, ** p<0.01, ***p < 0.0001.…”

LRC and SRC for specific rainfall lines. by Haim Weissmann (4707613)

“…<p>The date for 350-400 mm/year region (panels A-C) exemplify the typical scenario, where the LRC (panel A and with error bars in panels B and E) decreases monotonously with density. On the other hands, in panel D one notices that the 1999-2002 line appears to indicate positive feedback. …”

Table_1_Spatiotemporal characteristics and the national variations of borderland use change in Laos within the geopolinomical context.DOCX by Yi Wang (32470)

“…Through the use of land-use products from 1985 to 2020 and by employing GIS spatial analysis, the results indicate that (1) LUC along the Laos border has led to severe and extensive deforestation, primarily attributed to the rapid expansion of construction land and the consistent growth of cropland. (2) With strengthened border cooperation, differences between LUC in Laos and its neighboring countries have decreased since 1985. (3) Cropland and construction land on the Laos–China and Laos–Thailand borders show obvious bordering characteristics, with increasing land-use homogeneity in near-border areas. …”

Intestinal Adenocarcinomas Resistant to NVP-BEZ235 Have Variable Levels of activated AKT, MAPK, and Apoptosis. by Melanie H. Kucherlapati (136563)

“…<p>(A) ¹⁸F FDG PET image of a <i>Villin-Cre Msh2^−/−</i> mouse with NVP-BEZ235 resistant tumor with cyst (arrow). …”