Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease by Xiaojuan Han (3278601)

“…</p> <p><b>Abbreviations:</b> 3-MA: 3-methyladenine; AAV: adeno-associated virus; ACTB: actin, beta; AIF1/IBA1: allograft inflammatory factor 1; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A_1; BECN1: beclin 1, autophagy related; CASP1: caspase 1; CNS: central nervous system; CQ: chloroquine; DA neurons: dopaminergic neurons; DAMPS: damage-associated molecular patterns; DAPI: 4’,6-diamidino-2-phenylindole; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; GFAP: glial fibrillary acidic protein; IP: immunoprecipitation; i.p.: intraperitoneally; Ka: kaempferol; KD: knockdown; KO: knockout; LPS: lipopolysaccharide; IL1B: interleukin 1 beta; IL6: interleukin 6; Ly: lysate; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NC: negative control; NDD: neurodegenerative diseases; NLRP3: NLR family, pyrin domain containing 3; OE: overexpression; PD: Parkinson disease; poly-Ub: poly-ubiquitin; PTM: post-translational modification; PYCARD/ASC: PYD and CARD domain containing; Rapa: rapamycin; RFP: red fluorescent protein; SN: supernatant; SNCA: synuclein alpha; SNpc: substantia nigra pars compacta; SQSTM1: sequestosome 1; TH: tyrosine hydroxylase; TNF/TNF-alpha: tumor necrosis factor; Ub: ubiquitin; WT: wild type</p>…”

Data_Sheet_1_The Effect of Fermentation of High- or Low-Tannin Fava Bean on Glucose Tolerance, Body Weight, Cardiovascular Function, and Blood Parameters in Dogs After 7 Days of Fe... by Luciana G. Reis (10780209)

DataSheet1_Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction.doc by Liyun Zhang (280172)

“…We also observed elevated M1 macrophages and decreased M2 macrophages, which were exhibited by increased mRNA expression of M1 markers (iNOS, CD86, and CD80) and decreased mRNA expression of M2 markers (Arg1, CD163, and CD206) in HFpEF hearts. …”

DataSheet1_Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction.doc by Liyun Zhang (280172)

“…We also observed elevated M1 macrophages and decreased M2 macrophages, which were exhibited by increased mRNA expression of M1 markers (iNOS, CD86, and CD80) and decreased mRNA expression of M2 markers (Arg1, CD163, and CD206) in HFpEF hearts. …”

Data_Sheet_1_Determining factors for compensatory movements of the left arm and shoulder in violin playing.pdf by Oliver Margulies (14492024)

“…</p>Results<p>Mean “Reference Angle α” decreased significantly from 24.84 ± 2.67 to 18.61 ± 3.12° (p < 0.001), “Coord x” from 22.54 ± 7.417 to 4.75 ± 3.488 mm (p < 0.001), and “Coord y” from 5.66 ± 3.287 to 1.94 ± 1.901) mm (p < 0.001) when increasing LatAx-CSP and LoAx-HP by 30°. …”

DataSheet_1_Response of Afromontane soil organic carbon, nitrogen, and phosphorus to in situ experimental warming along an elevational gradient.pdf by Joseph Okello (13224300)

“…Further, soil bio-available P increased three-fold, from 9.6 ± 5.2 mg kg⁻¹ to 29.5 ± 3.0 mg kg⁻¹, with a linear increase of 1.4 mg kg⁻¹ per 100 m of elevation increase. …”

DataSheet_1_Dynamics of IgG antibody response against Plasmodium antigens among Nigerian infants and young children.pdf by Colleen M. Leonard (12199196)

“…</p>Methods<p>Blood samples collected during a 2018 Nigeria nationwide HIV/AIDS household survey were available for 9,443 children under 5 years of age, with a subset of infants under 2 months of age having maternal samples available (n=41). …”

Differential alteration of rumen microbial composition in response to 3-nitrooxypropanol supplementation in dairy cattle fed high-grain and high-forage diets by Youyoung Choi (17069818)

“…<i>ruminantium</i>, and <i>Methanosphaera</i> <i>sp</i>. Group5 and ISO3-F5, and decreases in <i>Mbb</i>. <i>gottschalkii</i> and <i>Methanomassiliicoccaceae</i> Group4 sp. …”

Representative Multifunctional Composition of Epitope-Specific CD8⁺ T Cell Responses against Conserved Epitopes or Epitopes with Sequence Variations in an Untreated Pati... by Hendrik Streeck (91376)

“…The functionality of the CD8⁺ T cell responses against the epitopes B8-EI9 in p24, B8-FL8 in Nef and Cw7-KY11 in Nef decreased to a primarily monofunctional composition, while the fraction of monofunctional epitope-specific CD8⁺ T cells decreased, and two- and three functional responses increased, for the epitope A3-RK9 in p17. …”

The weak activator Nrf1β/LCR-F1 is negatively regulated by its CTD. by Yiguo Zhang (512679)

“…The <i>left two panels</i> show western blotting of some of the above-transfected cell lysates with antibodies against either V5 (<b><i>a1</i></b>) or Xpress (<b><i>a2</i></b>). …”

Macrophage elasticity is modulated by actin polymerization and rhoGTPase acitivity. by Naimish R. Patel (136156)

“…<p><b>A.</b> Decreased polymerized actin staining and filapodia in macrophages cultured on a less rigid surface. …”

Table_1_Chlorophyll fluorescence, physiology, and yield of winter wheat under different irrigation and shade durations during the grain-filling stage.docx by Muhammad Asad Naseer (13976193)

“…The highest values were recorded in the I75 and SD12 treatments, which increased MDA, SOD, POD, and CAT activities by 65.22, 66.79, 65.07 and 58.38%, respectively, compared to the CK. The Pn, E, Gs, and iCO₂ exhibited a decreasing trend (318.14, 521.09, 908.77, and 90.85%) with increasing shading duration and decreasing irrigation amount. …”

Evaluation of dentinogenesis inducer biomaterials: an in vivo study by Anabela B. Paula (8073980)

“…The evaluations were performed in three stages; three, seven and twenty-one days, and consisted of an imaging (nuclear medicine) and histological evaluation (H&E staining, immunohistochemistry and Alizarin Red S). …”

Plasma lipid, cholesterol and free fatty acid levels in the Fgl1 null mouse. by Valeriy Demchev (385986)

“…B) Free fatty acid levels are decreased in the Fgl1 null mouse (P = 0.001). C and D) Plasma cholesterol levels are levels are lower as determined by total cholesterol (P = 0.003) and FPLC analysis. n = 5 per group.…”

Daphnetin reduced ear swelling and leukocytes infiltration. by Bocui Song (560180)

“…<p>Histological changes in right ear of mice at 24 h following elicitation with DNFB. (A) Control group: microphotograph showed normal structure of the ear; (B) DTH group: microphotograph showed histopathologic changes (edema, infiltration of inflammatory cells) of the ear; (C) CTX group; Daphnetin group (D: 5 mg/kg; E; 10 mg/kg; F: 20 mg/kg): microphotograph showing decreased histopathologic changes of the ear.…”

Arx is expressed in early differentiating GLP1-, GIP-, CCK- and Gastrin-expressing cells in the adult small intestine. by Anthony Beucher (167098)

“…Arx is strongly expressed in GLP1⁺, GIP⁺, CCK⁺, and selected Ghrl⁺ cells located in the crypts (B), but not in Sst⁺ or Serotonin⁺ (5-HT) cells. Arx expression level decreases in enteroendocrine cells in the villi (A). …”

Comparative analysis of the most significant Canonical Pathways throughout the entire dataset, and across multiple datasets. by Paul Chuchana (75344)

“…For each canonical pathway, we have compared the progression of this EV value for increasingly tolerant values by decreasing EV occurrence;  = 6/6: blue; ≥5/6: red; ≥4/6: green; ≥3/6: violet.…”

Reduction of tyrosine hydroxylase (TH)⁺ neurons after 6-hydroxydopamine (6-OHDA) administration. by Hideaki Matsui (716964)

“…(B) The numbers of dopaminergic neurons in the posterior tuberculum and noradrenergic neurons in the locus coeruleus are significantly decreased by 6-OHDA treatment in 12-month-old zebrafish; n = 5 fish per group. …”

The time course of serum dehydroepiandrosterone sulphate (DHEAS) levels in patients with septic shock (○), patients with multiple trauma (●), and age- and sex-matched control patie... by Albertus Beishuizen (70118)

“…<p><b>Copyright information:</b></p><p>Taken from "Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?"…”

WP1066 treatment of gp130^757FF mice inhibits growth factor expression in the antral mucosa. by Louise M. Judd (185660)

“…<p>gp130^757FF mice (8 weeks old) were treated as for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095993#pone-0095993-g005" target="_blank">Fig. 5</a>. mRNA for Reg1, amphiregulin and HB-EGF were analysed by Q-PCR analysis and quantified by the ΔΔCT method. …”