All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA‑E Immune Receptor Complex by Martin Ljubič (15680161)

“…In this study, we employed all-atom molecular dynamics simulations to investigate the impact of different membrane compositions on the conformational dynamics of the NKG2A/CD94/HLA-E immune receptor complex, a key negative regulator of natural killer cell cytotoxic activity. …”

9 mo Pkd2+/- mice have enhanced responses to acute ISO application. by Ivana Y. Kuo (707543)

Pravastatin increases cyclin D1 expression but prevents passage through S-Phase in NSPCs. by Ross A. Carson (5184512)

Statins alter mRNA expression in differentiating NSPCs through a non-CBP dependent mechanism. by Ross A. Carson (5184512)

Schematic diagrams of (A) fiber developmental stages and activity of six cotton fiber specific genes during fiber development and (B-E) the pCambia binary vectors and cotton fiber... by Junping Chen (182808)

Decreased levels of Fance transcription in homozygous mutant males. by Chun Fu (2553043)

Image2_Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T‐lymphocytes: A bioinformatic analysis.TIF by Runzhi Huang (7428713)

“…External validation based on multidimensional online databases and scRNA-seq analysis were used to verify our key findings.</p><p>Results: A six-different-dimension regulatory network was constructed based on 17 DEeRNAs, 29 DETFs, 9 DETGs, 5 immune cells, 24 immune gene sets, and 8 hallmarks of cancer. …”

Table2_Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T‐lymphocytes: A bioinformatic analysis.DOCX by Runzhi Huang (7428713)

“…External validation based on multidimensional online databases and scRNA-seq analysis were used to verify our key findings.</p><p>Results: A six-different-dimension regulatory network was constructed based on 17 DEeRNAs, 29 DETFs, 9 DETGs, 5 immune cells, 24 immune gene sets, and 8 hallmarks of cancer. …”

DataSheet1_Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter prot... by Gailing Liu (19503148)

“…This suggests that a 1-SD increase in HbA1c levels, regulated by the SLC5A2 gene, is associated with decreased eGFR. …”

Image4_Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter protein... by Gailing Liu (19503148)

“…This suggests that a 1-SD increase in HbA1c levels, regulated by the SLC5A2 gene, is associated with decreased eGFR. …”

Image3_Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter protein... by Gailing Liu (19503148)

“…This suggests that a 1-SD increase in HbA1c levels, regulated by the SLC5A2 gene, is associated with decreased eGFR. …”

Image1_Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter protein... by Gailing Liu (19503148)

“…This suggests that a 1-SD increase in HbA1c levels, regulated by the SLC5A2 gene, is associated with decreased eGFR. …”

Image6_Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter protein... by Gailing Liu (19503148)

“…This suggests that a 1-SD increase in HbA1c levels, regulated by the SLC5A2 gene, is associated with decreased eGFR. …”

SARS-CoV-2 infected K18-hACE2-Tg-mouse brain. by Motoki Imai (7324697)

Decrease of galectin-3 positive cells in bleomycin-injured lung tissue upon administration of hUC-MSC. by Gianluca Moroncini (784833)

“…<p>Macrophage infiltration in mouse lungs at days 8 (<b>A-D</b>) and 21 (<b>E-H</b>) after endotracheal injection of sterile saline (saline) (<b>A, E</b>) or bleomycin (bleomycin) (<b>B, F</b>), the latter also followed by intravenous infusion of hUC-MSC (bleomycin+hUC-MSC) (<b>D, H</b>) or sterile saline (bleomycin+saline) (<b>C, G</b>). …”

Trade-off between phenotypic variation (<i>V</i>_<i>ip</i>) and fitness. by Naoto Nishiura (11668953)

Subjects:

Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms by Ross A. Carson (5184512)

“…Genome-wide transcriptome analysis demonstrates an increase in expression of CBP genes following pravastatin treatment, through activation of the SREBP2 transcription factor. Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage. …”

CD43^-/- septic mice exhibit decreased frequencies of apoptotic CD4⁺ and CD8⁺ naïve T cells as compared to WT septic mice. by Katherine T. Fay (2576998)

“…B) CD43^-/- septic mice exhibited a decreased frequency of apoptotic naïve CD4⁺ T cells, defined as 7-AAD⁺ Annexin V⁺ CD44^LO CD62L^HI CD4⁺ cells, compared to WT septic mice (11.8±1.6 vs 18.8±1.3, p = 0.002. …”

Decreasing the front-to-rear difference of myosin II activity induced the collapse of leading front and reversed soma translocation of Schwann cells. by Ying Wang (11406)

Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation... by Diana P. Goméz-Mendoza (9104908)