Table_1_microRNA-145-5p inhibits prostate cancer bone metastatic by modulating the epithelial-mesenchymal transition.xlsx by Bingfeng Luo (13718917)

“…</p>Results<p>Levels of miRNA-145-5p were decreased in Pca bone metastases and miRNA-145-5p inhibited cell proliferation, migration and invasion. miRNA-145-5p inhibited the expression of basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF) and transforming growth factor-β (TGF-β) in PC3 cells. miR-145-5p increased the expression of the epithelial marker E-cadherin and reduced the expression of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9). …”

Table_1_Slc7a14 Is Indispensable in Zebrafish Retinas.pdf by You-Yuan Zhuang (8116280)

“…In addition, apoptotic cells were observed in the retina at 3 days post fertilization (dpf) and 5 dpf by TUNEL assay. Our results demonstrated that slc7a14 is essential for visually mediated behaviors in zebrafish. …”

Dataset for: Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5 and CFTR by Miriam Frankenthal Figueira (4089856)

“…Proteinuria is the main characteristic of DN and develops as a result of increased permeability of the glomerulus capillary wall and/or decreased proximal tubule endocytosis. …”

Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames by Lei Chen (54296)

“…Our results establish <i>PKD1</i> as a novel target of uORF-mediated translational regulation and mutations that perturb uORFs may dysregulate PKD1 protein level.…”

Image_1_The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.tif by Feng Wu (12185)

“…DNA-methyltransferase 3a (DNMT3a), a target gene of miR-199a-3p, was increased both in PTC cell lines and PTC tissues, while 5-aza-2′-deoxycytidine (methyltransferase-specific inhibitor) or knock-down using DNMT3a Small-Interfering RNA could restore the expression of miR-199a-3p, and the over-expression of miR-199a-3p could decrease the expression of DNMT3a; this suggests that miR-199a-3p/DNMT3a constructs a regulatory circuit in regulating miR-199a-3p/DNMT3a expression. …”

Table_1_The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.docx by Feng Wu (12185)

“…DNA-methyltransferase 3a (DNMT3a), a target gene of miR-199a-3p, was increased both in PTC cell lines and PTC tissues, while 5-aza-2′-deoxycytidine (methyltransferase-specific inhibitor) or knock-down using DNMT3a Small-Interfering RNA could restore the expression of miR-199a-3p, and the over-expression of miR-199a-3p could decrease the expression of DNMT3a; this suggests that miR-199a-3p/DNMT3a constructs a regulatory circuit in regulating miR-199a-3p/DNMT3a expression. …”

Table_2_The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.docx by Feng Wu (12185)

“…DNA-methyltransferase 3a (DNMT3a), a target gene of miR-199a-3p, was increased both in PTC cell lines and PTC tissues, while 5-aza-2′-deoxycytidine (methyltransferase-specific inhibitor) or knock-down using DNMT3a Small-Interfering RNA could restore the expression of miR-199a-3p, and the over-expression of miR-199a-3p could decrease the expression of DNMT3a; this suggests that miR-199a-3p/DNMT3a constructs a regulatory circuit in regulating miR-199a-3p/DNMT3a expression. …”

Breakdown of local information processing may underlie isoflurane anesthesia effects by Patricia Wollstadt (605354)

“…Information transfer between V1 and PFC was reduced bidirectionally, but with a stronger decrease from PFC to V1. …”

Microtubule organization in the tegument of <i>M. corti.</i> by Inés Guarnaschelli (18102211)

H₂S protected human pulmonary artery endothelial cells (HPAECs) from O₂-induced toxicity. by Arul Vadivel (424484)

“…(<b>D</b>) HPAECs were cultured for 48 hours in room air (Normoxia) or 95% hyperoxia. Mean data of cell viability as assessed by measuring the mitochondrial-dependent reduction of colorless 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) shows that hyperoxia significantly decreases HPAECs viability as compared with room air–exposed cells. …”

A Model For A Narrow-Cut Fractionating Column by Farag, Hassan A.

“…A mathematical model was developed to simulate the operation of a narrow-cut fractionating column. …”
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<i>Bmp2</i> upregulation in senescence. by Atsushi Kaneda (198186)

“…(<i>E</i>) Western blot analysis showing increased level of Smad1/5/8 phosphorylation in RasV12 cells, and decrease in <i>Bmp2</i>-knocked-down RasV12 cells. …”

Image_5_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…These results indicate that risperidone has a role in decreasing neuronal excitability and excitatory synapses, ameliorating repetitive behavior in the SIK1-truncated mice.…”

Immortality with tetraploidy is blocked in quiescent cells with diploidy, diminished H2AX, and no γH2AX foci. by Yuko Atsumi (209964)

“…<b>E.</b> DNA lesion-carryover into the G2-M phases was determined for lesions that spontaneously accumulated in senescent MEFs under Std-3T3 conditions. …”

Bortezomib treatment does not increase weight, locomotion, muscle strength or reduce plasma levels of CK and miRNA. by Zandra Körner (843029)

“…(E) Analysis of CK levels in plasma revealed a significant increase in CK levels in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i>mice, which was not significantly reduced by bortezomib. …”

Identification of Alzheimer’s disease susceptibility genes by the integration of genomics and transcriptomics by Chenghong OuYang (13521682)

“…Through ssGSEA analysis showed that all three core genes were significantly related to M2 macrophages.</p> <p>Three core genes were screened by integrating eQTLs data, GWAS data and transfer group data, and the potential mechanism of diagnosis and treatment of AD was revealed.…”

Severe kidney dysfunction and premature death in D2.<i>Ins2^Akita/+</i> mice. by Ileana Soto (531878)

“…(E) Decreased immunoreactivity of nestin was evident in D2.…”

Retinoic acid signalling inhibits myogenesis by blocking MYOD translation in pig skeletal muscle cells by Changying Wang (3967016)

Neutralization with additional bevacizumab to serum samples pre- and post-bevacizumab administration. by Masashi Okawa (8951294)

“…<b>d</b> VEGF-A165 concentrations were low in serum samples post-bevacizumab administration and remained low after further addition of bevacizumab. <b>e</b> The percent change in VEGF-A121 concentration with the addition of any (2, 20, or 200 μg/mL) concentration of bevacizumab to serum samples post-bevacizumab administration was significantly less than the percent change in VEGF-A121 concentration with the addition of 2 μg/mL concentration of bevacizumab to serum samples pre-bevacizumab administration (ANOVA: <i>p</i> < 0.0001; Dunnett’s multiple comparisons test: Post+2 μg/mL, <i>p</i> < 0.0001 vs Pre+2 μg/mL; Post +20 μg/mL, <i>p</i> < 0.0001 vs Pre+2 μg/mL; +200 μg/mL, <i>p</i> < 0.0001 vs Pre+2 μg/mL).…”

Number of significant genes and fold change. by Gordon A. Barr (11163243)

“…The effect of infant treatment on adult affective behavior showed a complex treatment by age dependent effect. Adult social behavior was decreased following Shock+mother pairings at both PN5-9 and PN10-14, whereas shock alone had no effect. …”