Ablation of caspase-2 results in bone loss. by Ramaswamy Sharma (247989)

“…<p>(A) Dual X-ray energy absorptiometry (DXA) analysis indicated a significant decrease in total (n = 10; <i>*</i>, <i>p</i> = 0.0017) and femoral (n = 10; <i>*</i>, <i>p</i> = 0.0016) bone mineral density (BMD) in 27-month old male <i>Casp2^−/−</i> mice as compared to <i>Casp2^+/+</i> mice. …”

Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase by Jason P. Schwans (1320693)

“…Prior site-directed mutagenesis studies in bacterial ketosteroid isomerase (KSI) reported that substitution of both oxyanion hole hydrogen bond donors gives a 10⁵- to 10⁸-fold rate reduction, suggesting that the oxyanion hole may provide the major contribution to KSI catalysis. …”

Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase by Jason P. Schwans (1320693)

“…Prior site-directed mutagenesis studies in bacterial ketosteroid isomerase (KSI) reported that substitution of both oxyanion hole hydrogen bond donors gives a 10⁵- to 10⁸-fold rate reduction, suggesting that the oxyanion hole may provide the major contribution to KSI catalysis. …”

Microbiome dataset supporting paper "A preclinical randomized controlled multicenter trial of anti-IL-17A treatment for acute ischemic stroke" by Simon Koch (14322384)

MRI dataset supporting paper "A preclinical randomized controlled multicenter trial of anti-IL-17A treatment for acute ischemic stroke" by Simon Koch (14322384)

Penam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition by Elizabeth A. Rodkey (510008)

“…We next demonstrated using protein crystallography that increasing the linker length by one carbon allowed for better capture of a <i>trans</i>-enamine intermediate; in contrast, this <i>trans</i>-enamine intermediate did not occur when the C2 linker length was decreased by one carbon. If the linker was altered by both shortening it and changing the carboxyl moiety into a neutral amide moiety, the stable <i>trans</i>-enamine intermediate in <i>wt</i> SHV-1 did not form; this intermediate could only be observed when a deacylation deficient E166A variant was studied. …”

S1 File - Ecological properties of soil improved by high–performance ester materials under freeze–thaw cycles conditions by Cuiying Zhou (10048078)

CORT triggered a slow-onset increase in GluN2A/GluN2B ratio. by Yiu Chung Tse (340737)

“…(<b>E</b>) Histogram summarizes the percentage blockade by a cocktail of NVP-AAM077 and Ro in NMDAR-EPSCs recorded in control and <i>1</i>–<i>2 hrs after CORT</i> slices. …”

Acute effect of timolol on intracellular global Ca²⁺ changes, and the basal levels of intracellular both free Zn²⁺ and Ca²⁺ in ventricular hypergly... by Erkan Tuncay (438815)

“…(E) Incubation of cardiomyocytes with a zinc-ionophore of 1-hydroxypyridine-2-thione (ZnPT; 1-μM and 10-μM) at 37°C for 20–30 min did not affect total protein levels of RyR2 and its accessory protein of RyR2 macromolecular complex FKBP12.6 and two important kinases PKA and CaMKII while phosphorylation levels of RyR2 as well as PKA and CaMKII (pPKA and pCaMKII, respectively) increased markedly with ZnPT incubation in a concentration-dependent manner. …”

DataSheet2_Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H2O2-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nr... by Tianke Yang (13028373)

“…AKBA significantly decreased the expression of caspase-3 and Bax and increased the content of Bcl-2. …”

Table3_Potential Target Analysis of Triptolide Based on Transcriptome-Wide m6A Methylome in Rheumatoid Arthritis.xlsx by Danping Fan (5913008)

“…Molecular docking and in vitro experiment suggested that TP and IGF2BP3 had a high binding affinity and TP could decrease the mRNA expression of IGF2BP3 in PBMCs and MH7A.This research established a transcriptional map of m⁶A in RA PBMCs and displayed the hidden association between RNA methylation alterations and associated genes in RA. …”

Histology dataset supporting paper "A preclinical randomized controlled multicenter trial of anti-IL-17A treatment for acute ischemic stroke" by Simon Koch (14322384)

Table2_Potential Target Analysis of Triptolide Based on Transcriptome-Wide m6A Methylome in Rheumatoid Arthritis.xlsx by Danping Fan (5913008)

“…Molecular docking and in vitro experiment suggested that TP and IGF2BP3 had a high binding affinity and TP could decrease the mRNA expression of IGF2BP3 in PBMCs and MH7A.This research established a transcriptional map of m⁶A in RA PBMCs and displayed the hidden association between RNA methylation alterations and associated genes in RA. …”

DataSheet1_Potential Target Analysis of Triptolide Based on Transcriptome-Wide m6A Methylome in Rheumatoid Arthritis.docx by Danping Fan (5913008)

“…Molecular docking and in vitro experiment suggested that TP and IGF2BP3 had a high binding affinity and TP could decrease the mRNA expression of IGF2BP3 in PBMCs and MH7A.This research established a transcriptional map of m⁶A in RA PBMCs and displayed the hidden association between RNA methylation alterations and associated genes in RA. …”

FACS dataset supporting paper "A preclinical randomized controlled multicenter trial of anti-IL-17A treatment for acute ischemic stroke" by Simon Koch (14322384)

Table4_Potential Target Analysis of Triptolide Based on Transcriptome-Wide m6A Methylome in Rheumatoid Arthritis.xlsx by Danping Fan (5913008)

“…Molecular docking and in vitro experiment suggested that TP and IGF2BP3 had a high binding affinity and TP could decrease the mRNA expression of IGF2BP3 in PBMCs and MH7A.This research established a transcriptional map of m⁶A in RA PBMCs and displayed the hidden association between RNA methylation alterations and associated genes in RA. …”

Table1_Potential Target Analysis of Triptolide Based on Transcriptome-Wide m6A Methylome in Rheumatoid Arthritis.xlsx by Danping Fan (5913008)

“…Molecular docking and in vitro experiment suggested that TP and IGF2BP3 had a high binding affinity and TP could decrease the mRNA expression of IGF2BP3 in PBMCs and MH7A.This research established a transcriptional map of m⁶A in RA PBMCs and displayed the hidden association between RNA methylation alterations and associated genes in RA. …”

Table_6_Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes.XLSX by Soon-Sun Bak (9472454)

“…Thus, we investigated whether the trichogenicity of the cells was affected by FOXA2 expression. We found a significant decrease in the number of induced hair follicles when the ORS cells were transfected with a FOXA2 small interfering RNA versus control small interfering RNA. …”

Table_3_Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes.XLSX by Soon-Sun Bak (9472454)

“…Thus, we investigated whether the trichogenicity of the cells was affected by FOXA2 expression. We found a significant decrease in the number of induced hair follicles when the ORS cells were transfected with a FOXA2 small interfering RNA versus control small interfering RNA. …”

Image_3_Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes.TIF by Soon-Sun Bak (9472454)

“…Thus, we investigated whether the trichogenicity of the cells was affected by FOXA2 expression. We found a significant decrease in the number of induced hair follicles when the ORS cells were transfected with a FOXA2 small interfering RNA versus control small interfering RNA. …”