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point decrease » point increase (Expand Search)
e decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX
Published 2020“…</p><p>Conclusions: The present study shows for the first time that the SGLT2 inhibitor Empagliflozin has acute specific metabolic effects in isolated diabetic hearts, i.e., decreased lactate generation from labeled glucose and increased α-ketoglutarate synthesis from labeled palmitate. …”
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Polymorphisms in <i>CYP1B1</i>, <i>CYP3A5</i>, <i>GSTT1</i>, and <i>SULT1A1</i> Are Associated with Early Age Acute Leukemia
Published 2015“…Using data from the Brazilian Collaborative Study Group of Infant Acute Leukemia (2000–2012), 350 cases and 404 age-matched controls and 134 mothers of cases and controls were genotyped to explore polymorphisms in genes of the estrogen metabolism pathway: <i>CYP1B1</i> (c.1294C>G, rs1056836), <i>CYP3A4</i> (c.-392A>G, rs2740574), <i>CYP3A5</i> (c.219-237G>A, rs776746), <i>GSTM1/GSTT1</i> deletions, and <i>SULT1A1</i> (c.638G>A, rs9282861; and c.667A>G, rs1801030). …”
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Viral ORF57 inhibits eIF2α phosphorylation through down-regulation of PKR pathway.
Published 2017“…<p>(A) Diagrams of four major stress pathways leading to phosphorylation of eIF2α via different kinases. PERK, PKR-like endoplasmic reticulum kinase; PKR, protein kinase R; GCN2, general control nonderepressible 2; HRI, heme regulated inhibitory kinase. …”
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Table_5_Exploring the multifaceted therapeutic mechanism of Schisanlactone E (XTS) in APP/PS1 mouse model of Alzheimer’s disease through multi-omics analysis.XLSX
Published 2024“…After an acclimatization period of 7 days, intraperitoneal injections were administered over a 60-day treatment period. The NC and M groups received saline, while the Tre group received XTS at 2 mg/kg. …”
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Data Sheet 2_MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway.pdf
Published 2025“…In vitro experiments, in which high glucose concentrations were used to stimulate human mesangial cells (HMCs), demonstrated a significant increase in the protein level of high mobility group box 1 (HMGB1) and a marked decrease in miR-216a-5p expression (all P < 0.05). …”
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Data Sheet 1_MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway.docx
Published 2025“…In vitro experiments, in which high glucose concentrations were used to stimulate human mesangial cells (HMCs), demonstrated a significant increase in the protein level of high mobility group box 1 (HMGB1) and a marked decrease in miR-216a-5p expression (all P < 0.05). …”
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Less Iso-induced decrease of APD<sub>90</sub> in female hearts.
Published 2014“…B) Summary data for the decrease in APD<sub>90</sub> (versus baseline values) as a function of the dose of Iso (1, 10, 31.6, 100, 316.2 nM) in the LV base (left) and apex of female (n = 5) and male (n = 5) hearts during pacing at 3 Hz (<i>top</i>) and 5.5 Hz (<i>bottom</i>). …”
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