Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid‑1 Receptor Antagonists for Metabolic Syndrome Disorders by Szabolcs Dvorácskó (14767447)

“…We have designed orally bioavailable, non-brain-penetrant antagonists of the cannabinoid-1 receptor (CB₁R) with a built-in biguanide sensor to mimic 5′-adenosine monophosphate kinase (AMPK) activation for treating obesity-associated co-morbidities. …”

Comparison of harmonic blade versus traditional approach in canine patients undergoing spinal decompressive surgery for naturally occurring thoracolumbar disk extrusion by Bianca F. Hettlich (3809359)

“…</p><p>Conclusions</p><p>The HOB is a safe and effective tool for the soft tissue approach for routine spinal surgery in dogs and is associated with decreased pain and increased neurological function post-surgery.…”

Supplementary Material for: Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy by Sugase T. (2871863)

“…The median progression-free survival (PFS) and overall survival (OS) for ETS ≥20% and <20% were 12.7 and 5.5 months and 14.4 and 8.2 months, and 12.7 and 4.9 months and 14.4 and 8.0 months for DpR ≥30% and <30%, respectively. …”

Bifurcation figures of the S-I-P-B dynamics, presenting maximum and minimum values (black circles), as well as equilibrium densities when competitor (<i>B</i>) is not present (red... by Ilona Merikanto (115920)

“…<p>a) Dynamics are cyclic when susceptible host growth rate (<i>r_S</i>) is 0.01, outside-host growth rate of pathogen (<i>r_P</i>) is 0.05 and <i>f_BP</i> varies between 0 and 10⁻⁵. b) When <i>r_S</i> = 0.01, <i>r_P</i> = 0.05 and <i>f_BP</i> = 10⁻⁷–10⁻⁴, dynamics are first cyclic and the densities of <i>P</i>, <i>S</i> and <i>I</i> are decreasing as <i>f_BP</i> and the density of <i>B</i> increase. …”

DataSheet_1_Structural and functional alteration of the gut microbiota in elderly patients with hyperlipidemia.docx by Meng Xia (29894)

“…These groups were further subdivided by sex into the male normal (NM, n = 5), female normal (NF, n = 5), male hyperlipidemia (MM, n = 8), and female hyperlipidemia (MF, n = 8) subgroups. …”

Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid‑1 Receptor Antagonists for Metabolic Syndrome Disorders by Szabolcs Dvorácskó (14767447)

“…We have designed orally bioavailable, non-brain-penetrant antagonists of the cannabinoid-1 receptor (CB₁R) with a built-in biguanide sensor to mimic 5′-adenosine monophosphate kinase (AMPK) activation for treating obesity-associated co-morbidities. …”

Image_3_Function and Mechanism of Trimetazidine in Myocardial Infarction-Induced Myocardial Energy Metabolism Disorder Through the SIRT1–AMPK Pathway.JPEG by Xiu-ying Luo (10984614)

“…The current study set out to evaluate the effect and mechanism of TMZ on MEM disorder induced by myocardial infarction (MI). Firstly, a MI mouse model was established by coronary artery ligation, which was then treated with different concentrations of TMZ (5, 10, and 20 mg kg^–1 day^–1). …”

Intranasal mucoadhesivemicroemulsion for neuroprotective effect of curcuminin mptp induced Parkinson model by Snigdha Das Mandal (12847079)

“…Male C57BL/6 mice were first treated with four intraperitoneal injections of MPTP (20 mg/kg of body weight) at 2 h intervals followed CMME intranasal administration for 14 days at 2.86 mg of curcumin/kg of body weight per once a day. Optimal CMME containing 3% Capmul MCM as oil phase, 37 % of Accenon CC and Transcutol HP at 2.5:1 ratio and 0.5% sodium hyaluronate was stable, non-ciliotoxic with 57.66 nm±3.46 as average globule size. …”

Amphiphobic Polytetrafluoroethylene Membranes for Efficient Organic Aerosol Removal by Shasha Feng (2573317)

“…Herein, we report the fabrication of a new amphiphobic 1H,1H,2H,2H-perfluorodecyl acrylate (PFDAE)-grafted ZnO@PTFE membrane with enhanced antifouling functionality and high removal efficiency. …”

NFYA1 Is Involved in Regulation of Postgermination Growth Arrest Under Salt Stress in <i>Arabidopsis</i> by Yan-Jie Li (393413)

“…On the other hand, the <i>NFYA1-RNAi</i> lines were found to be insensitive to salt stress and exhibited decreased levels of <i>ABI3</i>, <i>ABI5</i>, <i>EM1</i>, and <i>EM6</i> transcripts. …”

Table 1_Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.xlsx by Yinghong Zhou (6873053)

“…Among these, 1,975 (67.5%) enrolled no more than 100 participants, and 153 (5.2%) were restricted to either males or females, with this gender-specific enrollment correlated with disease epidemiology. …”

Image_11_Function and Mechanism of Trimetazidine in Myocardial Infarction-Induced Myocardial Energy Metabolism Disorder Through the SIRT1–AMPK Pathway.JPEG by Xiu-ying Luo (10984614)

“…The current study set out to evaluate the effect and mechanism of TMZ on MEM disorder induced by myocardial infarction (MI). Firstly, a MI mouse model was established by coronary artery ligation, which was then treated with different concentrations of TMZ (5, 10, and 20 mg kg^–1 day^–1). …”

Limited indirect effects of an infant pneumococcal vaccination program in an aging population by Mark van der Linden (109670)

“…</p><p>Methods and findings</p><p>Reported IPD cases decreased in children under two years of age from 11.09 per 100,000 in 2003–2006 to 5.94 per 100,000 in 2017/18, while in adult age groups, reported IPD cases rose across the board, most dramatically in adults 60 years of age and over, from 1.64 to 10.08 cases per 100,000. …”

Image_8_Function and Mechanism of Trimetazidine in Myocardial Infarction-Induced Myocardial Energy Metabolism Disorder Through the SIRT1–AMPK Pathway.JPEG by Xiu-ying Luo (10984614)

“…The current study set out to evaluate the effect and mechanism of TMZ on MEM disorder induced by myocardial infarction (MI). Firstly, a MI mouse model was established by coronary artery ligation, which was then treated with different concentrations of TMZ (5, 10, and 20 mg kg^–1 day^–1). …”

Data Sheet 1_Morphophysiological and transcriptomic analyses during the development of microspores and megaspores in Orobanche coerulescens.docx by Kelin Cui (20936231)

“…Introduction<p>Orobanche coerulescens is a parasitic plant considered as a malignant weed due to its harmful effects on crops. …”

Table_2_Dietary Corn Bran Altered the Diversity of Microbial Communities and Cytokine Production in Weaned Pigs.doc by Ping Liu (156158)

“…On day 28, piglets fed dietary CB had a higher shannon index (P < 0.05). The population of the Firmicutes in CB treatment were decreased (P < 0.05), while the percentage of the Bacteroidetes were increased (P < 0.05). …”

Supplementary Material for: Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy by Sugase T. (2871863)

“…The median progression-free survival (PFS) and overall survival (OS) for ETS ≥20% and <20% were 12.7 and 5.5 months and 14.4 and 8.2 months, and 12.7 and 4.9 months and 14.4 and 8.0 months for DpR ≥30% and <30%, respectively. …”

Data_Sheet_1_Function and Mechanism of Trimetazidine in Myocardial Infarction-Induced Myocardial Energy Metabolism Disorder Through the SIRT1–AMPK Pathway.docx by Xiu-ying Luo (10984614)

“…The current study set out to evaluate the effect and mechanism of TMZ on MEM disorder induced by myocardial infarction (MI). Firstly, a MI mouse model was established by coronary artery ligation, which was then treated with different concentrations of TMZ (5, 10, and 20 mg kg^–1 day^–1). …”

Image 3_Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis.tif by Tao Sun (91038)

“…Introduction<p>The Th2 immune response plays a pivotal role in the pathogenesis of schistosomiasis, contributing to the formation of hepatic granulomas and fibrosis. …”

DOT-1.1 and ZFP-1 are required for normal chromatin-associated H3K79me1,-2,-3 signal in the <i>C</i>. <i>elegans</i> germline. by Laura I. Lascarez-Lagunas (8275293)

“…<i>1; ced-3</i> and, less dramatically, in the <i>zfp-1</i> mutant, this signal is decreased. Premeiotic tip (zone 2), transition zone (zone 3) and pachytene (zone 5) nuclei are shown. …”