PF-04991532 regulates glucose metabolism in primary rat hepatocytes. by Derek M. Erion (568011)

“…<p>Structure of PF-04991532 [(S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1yl)propanamido)nicotinic acid] (<b>A</b>) increased glucose uptake (n = 5) (<b>B</b>), decreased glucose production from radiolabeled lactate (n = 4) (<b>C</b>), and increased CO₂ production from glucose (n = 6) (<b>D</b>) in primary rat hepatocytes.…”

Cd regulated the expression levels of Bcl-2 and Bax. by Yan Yuan (20767)

“…<p>(A and B) Cerebral cortical neurons were treated with Cd (0, 5, 10, 20 µM) for 12 h, or 10 µM Cd for 0–48 h and then assessed by Western blotting. β-actin was used as an internal control. …”

Response curves of the environmental gradients in the MaxEnt model for Beam-Sole, in relation to the abundance of the specific environmental condition. by Karin J. van der Reijden (3267498)

“…Only curves that explain >5% of the model are included.</p>…”

Influence of the rate constants for Gα*/AC* formation and dissociation. by Ayse Yarali (327662)

“…Color-coded representation of the size of the peak negative (left) and positive (right) associative effects. In (A), (B1) and (B2), we systematically change the rate constants for Gα*/AC* formation and dissociation (k₅ and k_-5 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032885#pone-0032885-g003" target="_blank">Fig. 3A</a>). …”

Knockdown of the expression of KLF4 in spheroid cells altered their stemness. by Zhengwei Leng (281714)

“…<p>(A) The survival rate was similar among both DLD-S siCon and DLD-S siKLF4 cells as assessed by Annexin-V APC/PI Double Labelling assay. …”

The impact of the duration of journeys on travel between districts. by Amy Wesolowski (105098)

“…As the duration of journeys increased, the amount of travel between districts decreased. B) For all trips including any trip duration (red) and those lasting 4+ months (grey), the top 5% of of routes are shown based on the total amount of travel. …”

Normally developed pancreas despite shortened telomeres in telomerase knockout mice. by Guido von Figura (229502)

“…<p>(A) Representative H&E sections of mTerc^+/+ and G3 mTerc^−/− mice reveal no differences in pancreas histology (size bar  = 1 mm). …”

GCase protein and activity in diltiazem-treated mice: by Ying Sun (23237)

“…D409H livers had ∼1.2-fold increases of GCase activity. GCase activity in V394L liver decreased 38% after treatment. No significant changes in GCase activity were detected in WT, D409H and V394L brain, spleen, and lung. …”

Macrophage apoptosis and necrosis. by Lia Danelishvili (249418)

“…The decreased level of apoptosis during the infection with virulent <i>M. tuberculosis</i> is related to duration of macrophage infection; however, <i>M. tuberculosis</i> triggers a greater level of necrosis at later time points than apoptosis. …”

Functional response of Trichogramma pretiosum on Trichoplusia ni eggs at different temperatures and egg densities by André Malacarne Milanez (5669381)

“…Females of Trichogramma pretiosum show greater efficiency at 30ºC and a type-II functional response. The parasitism rate decreases, when host density increases.…”

Remifentanil infusion increases the GSK-3β activity in spinal dorsal horn. by Yize Li (471459)

“…<p>The total GSK-3β and phosphorylated GSK-3β in spinal dorsal horn were tested by Western blot. β-actin was used as the internal standard (a). The band intensity of C group was assigned a value of 1. …”

BTBR mice show impaired accuracy, omissions and impulsivity. by Stephanie M. McTighe (406642)

“…In these sessions, ITI was held constant at 5 seconds, and mice were given one session at each of 4, 2, 0.8 and 0.4 second stimulus duration. …”

NT-4 expression profile. by Jin-Young Chung (390854)

“…Exercise induces increased expression of dimers, more so in the milder condition (I: mild, II: moderate, III: severe) (p<0.05, n = 5). (<b>D</b>) The distribution of immunoreactivity by exercise increased adjacent to the ischemic region (b) comparing to the ischemia-only control (a). ▄ = 100 um.…”

SIRT (1–7) mRNA reductions with increasing passage number is augmented with HG treatment in HUVECs. by Rokhsana Mortuza (102995)

“…<p>(A) SIRT (1–7) mRNA expressions are decreased in large vessel endothelial cells (HUVEC) with increasing passages and with HG it is escalated (analyzed by quantitative Real Time RT-PCR). mRNA levels are expressed as a ratio to β-actin and normalized to baseline controls, NG P0 (before treatment began). …”

FGF signaling is necessary for endothelial cell monolayer integrity. by Kunihiko Hatanaka (322096)

“…<p><b>A.</b> Endothelial monolayer permeability evaluated with the ECIS system. …”

Expression profiling of miRNAs in the DRG following sciatic nerve injury. by Iain T. Strickland (210350)

“…Colour coding: control versus axotomised DRG on a logarithmic scale; green represents decreased level while red represents increased level in axotomised DRG (n = 3). …”

Mechanical Behaviour of Metallic Yielding Dampers with Different Aspect Ratios by Ahmed Sabah Aljawadi (10476184)

“…This study investigated the behavior of yielding shear plates with different aspect ratios when subjected to a gradually increasing lateral load. Five shear links with the thickness of 1mm and aspect ratios ranging from 1.0 to 1.5 were constructed and tested. …”

No change in amount of HGF protein or hepatocyte proliferation in HGF KO mice after PH. by Kari Nejak-Bowen (392168)

“…<p>(<b>A</b>) Genomic recombination is present in cre-inducible HGF^{ex.5 flox} KO mice at all time points after PH, as assessed by PCR. …”

Model Hirano bodies protect against tau-dependent cell death. by Matthew Furgerson (134418)

“…Transfection of 352PHP tau decreases the amount of exogenous APP (1.5 µg versus 3.0 µg of APP in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044996#pone-0044996-g002" target="_blank">Figure 2</a>) required to achieve significant enhancement of cell death. …”

Combined treatment of PJ, ATRA and 9-<i>cis</i> effect cell cycle protein expression in primary HSCs. by Efrat Sharvit (465323)

“…<p><b>A</b>. Combined treatment of PJ, ATRA and 9-<i>cis</i> decreased cyclin D1 expression in primary rat HSCs. …”