Table 4_Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice.xlsx by Ling Kui (6108440)

“…An open-label, single-center, investigator-initiated clinical study (ChiCTR25001192) was conducted in which participants, who received the endolysin gel twice daily, underwent follow-up assessments at baseline, treatment weeks 1 and 2, with an optional extension up to 3 months.</p>Results<p>Statistically significant reductions in skin lesion scores, S. aureus load, and AD-related immune mediators (i.e., IgE, TSLP, IL-33) were observed in the Staphyrase^® group relative to the model group. …”

Image_8_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_1_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_6_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_7_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_3_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_2_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Data_Sheet_1_First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction.docx by Lien-Cheng Hsiao (13217106)

“…The NT-proBNP level decreased (1362 ± 1801 vs. 109 ± 115 pg/mL, p = 0.0313), the LVEF increased (52.67 ± 12.75% vs. 62.47 ± 17.35%, p = 0.0246), and the wall motion score decreased (26.33 ± 5.57 vs. 22.33 ± 5.85, p = 0.0180) at the 12-month follow-up compared to the baseline values. …”

Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Table1_The Expression of Cytokine Profiles and Related Receptors in Idiopathic Inflammatory Myopathies.docx by Junyu Zhou (1548346)

“…The number of IL18R1⁺CD4⁺ cells was increased while IL18R1⁺CD8⁺ cells was decreased in peripheral blood of anti-MDA5 patients.…”

Effect of TMN lesion on appetitive behavior. by Marco Contreras (2158465)

“…(<b>d)</b> The lesion had to involve both TMN divisions to be effective on drinking behavior. (<b>e)</b> TMN lesion decreased the time spent in the amphetamine-paired box in conditioned rats. …”

TGFβR1 kinase activity is necessary for VE-cadherin expression. by Priya Prahalad (50952)

“…Treatment with SB431542 decreases PAI-1 activity, confirming TGFβR1 blockade (b).The samples are as follows: 1 - Control; 2 - RA; 3 - Control, 10 µM SB431542; 4 - RA, 10 µM SB431542; 5 - Control - 50 µM SB431542; 6 - RA, 50 µM SB431542. …”

Bursts statistics in the presence of synaptic blockers. by Alberto Mazzoni (54739)

“…The black dashed line has a slope of −1.5 in (A) and of −2 in (B), as in the right and left column of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000439#pone-0000439-g009" target="_blank">Figure 9</a>, respectively. …”

Baseline characteristics of participants. by Mei Zhou (269746)

“…Linear regression indicated a positive association between intervention and expenditures (0.5%increase). …”

The framework diagram of this study. by Mei Zhou (269746)

“…Linear regression indicated a positive association between intervention and expenditures (0.5%increase). …”

Neuronal response to an external current. by Eduarda Susin (11442545)

“…<p>A: External drive fluctuation. External current, in each neuron, varied from 0 to 0.5 nA in a linear way, was kept constant for 500 ms, subsequently decreasing to 0 nA in a linear way. …”

Gene body coverage for transcripts longer than 5000 nt. by Benjamín Sigurgeirsson (535869)

“…<p>For transcripts longer than 5000<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091851#pone-0091851-g005" target="_blank">Figure 5</a>. …”

Temporal analysis of night rides on the full dataset. by Miklós Mezei (13919384)

“…The hour-wise analysis shows a constant usage before midnight and a decreasing trend before 5 am. …”

Natural odors elicit odor-selective and chemotopically organized responses in the contralateral OB. by Florence Kermen (362513)

“…Arrowheads indicate odor onset. (E) Odor response time course of all contralateral mitral cells pooled and sorted by decreasing responsiveness (715 cells in six fish). …”

Peaks in the relapse rate. by Lisa Willis (410078)

“…<p>RFI curves (top) and corresponding relapse rates (bottom) for Models 1–3 as parameters (Model 1)/ (Model 2)/ (Model 3) are reduced. In each plot, // decreases such that the ratio of the right-hand side to the left-hand side of the corresponding inequality determining whether there is a peak in the relapse rate is 2 (long-dashed line), 1 (short-dashed line), 1/5 (dotted line) and 1/25 (solid line).…”