Use of Fixed Dose Combination (FDC) Drugs in India: Central Regulatory Approval and Sales of FDCs Containing Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Metformin, or Psychotro... by Patricia McGettigan (203640)

“…</p><p>Methods and Findings</p><p>This was an ecologic study with a time-trend analysis of FDC sales volumes (2007–2012) and a cross-sectional examination of 2011–2012 data to establish the numbers of formulations on the market with and without a record of CDSCO approval (“approved” and “unapproved”), their branded products, and sales volumes. …”

Projection-resolved optical coherence tomography angiography (PR-OCTA) of retinal angiomatous proliferation (RAP). by Alaa E. Fayed (6703916)

“…<p>Spectral domain-OCT (SD-OCT), projection artifact removal (PAR) OCTA (Optovue, Inc.) and PR-OCTA scans at thresholds of 0.5, 0.7 and 1.0 of the same eye in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0217109#pone.0217109.g001" target="_blank">Fig 1</a>. …”

FGF2 delays the birthdates of neurons in deep, superficial and middle layers. by Luke D. McGowan (483282)

“…<p>In the rostroventral tectum of FGF2- treated embryos infused with EdU starting on ED5, the proportion of EdU-unlabeled cells is decreased by 32, 72, and 57% in the deep, superficial, and middle tectal layers, respectively (A). …”

Excitation-Contraction Coupling in Zebrafish Ventricular Myocardium Is Regulated by Trans-Sarcolemmal Ca²⁺ Influx and Sarcoplasmic Reticulum Ca²⁺ Release by Moritz Haustein (734263)

“…Surprisingly though, inhibition of the sarcoplasmic Ca²⁺-release decreased force development to 54±3% in ventricular (n=13, p<0.05) and to 52±8% in atrial myocardium (n=5, p<0.05) suggesting a substantial role of SR Ca²⁺-release in force generation. …”

Table 1_Fermented strawberry pomace enhances carcass characteristics and meat quality by regulating plasma biochemical indices and antioxidant capacity in aged laying hens.docx by Wei Lan (1390307)

“…All FSP groups exhibited a decreasing trend in plasma TG level (p = 0.057). …”

Kinetics and Mechanisms of Dissolution and Growth of Acicular Triclinic Calcium Pyrophosphate Dihydrate Crystals by Margaret R. Christoffersen (2952417)

“…At higher pH (5.5 and 6.5), the rates of growth per unit area of acicular t-CPPD are slower than corresponding rates for columnar t-CPPD. …”

Kinetics and Mechanisms of Dissolution and Growth of Acicular Triclinic Calcium Pyrophosphate Dihydrate Crystals by Margaret R. Christoffersen (2952417)

“…At higher pH (5.5 and 6.5), the rates of growth per unit area of acicular t-CPPD are slower than corresponding rates for columnar t-CPPD. …”

Kinetics and Mechanisms of Dissolution and Growth of Acicular Triclinic Calcium Pyrophosphate Dihydrate Crystals by Margaret R. Christoffersen (2952417)

“…At higher pH (5.5 and 6.5), the rates of growth per unit area of acicular t-CPPD are slower than corresponding rates for columnar t-CPPD. …”

Kinetics and Mechanisms of Dissolution and Growth of Acicular Triclinic Calcium Pyrophosphate Dihydrate Crystals by Margaret R. Christoffersen (2952417)

“…At higher pH (5.5 and 6.5), the rates of growth per unit area of acicular t-CPPD are slower than corresponding rates for columnar t-CPPD. …”

Upregulation of Innate Antiviral Restricting Factor Expression in the Cord Blood and Decidual Tissue of HIV-Infected Mothers by Nátalli Zanete Pereira (427812)

“…The mRNA and protein expression levels of antiviral factors were then evaluated. We observed a significant increase in the mRNA expression levels of antiviral factors in MNCs from HIV-infected mothers and CB, including the apolipoprotein B mRNA-editing enzyme 3G (A3G), A3F, tripartite motif family-5α (TRIM-5α), TRIM-22, myxovirus resistance protein A (MxA), stimulator of interferon (IFN) genes (STING) and IFN-β, compared with the levels detected in uninfected (UN) mother-CB pairs. …”

PZP efficacy and number of consecutive PZP applications. by Cassandra M. V. Nuñez (360455)

“…Across the first four consecutive applications, PZP efficacy declined, returning to 100% after five or more consecutive applications (5–7 applications have been shown to result in ovulation failure and decreased oestrogen levels <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013635#pone.0013635-Kirkpatrick3" target="_blank">[5]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013635#pone.0013635-Kirkpatrick4" target="_blank">[40]</a>).…”

Mulitfocal alternating proliferation and cancer stem cell marker expression in a tumor with a prominent CSC-like Ad-ACA transtional zone. by Kevin J. Arvai (758476)

“…(E,F) The Ad-ACA transition in another tumor shows multifocal stretches of adenomatous epithelium with loss of EZH2 and ALDH1 expression. …”

NBCe1 membrane expression during secretagogue stimulation and PKC inhibition with Gö6850 or Gö6976. by Oliver May (538881)

“…<p>In cell surface biotinylation experiments, neither Gö6850 (A; 5 μM) nor Gö6976 (B; 5 μM; continuous incubation for 20 min [+] vs. vehicle [−]) caused changes in NBCe1 surface expression. …”

Milk production and economic assessment of cassava bagasse in the feed of dairy cows by Leandro Pereira Lima (5885036)

“…<div><p>The addition of 0; 5; 10 and 15% cassava bagasse, based on the dry matter of the total diet of crossbred Holstein v. …”

Network Activation - memristive behavior. by Audrius V. Avizienis (145238)

“…<p>(a) Representative example of initial bias sweeps (0–5 V sweep at 1 V/s) applied to a pristine device which steadily activate higher percentages of atomic switches, resulting in increased current. …”

Aqueous extract of pequi fruit to control Spodoptera frugiperda in corn by Maria das Dores da Cruz Souza (5608952)

“…Field-grown corn plants of the cultivar ‘Al Alvaré’ were sprayed with extract concentrations of 0.8%, 2.5%, 5%, and 10% (v/v) 40 and 47 days after germination. …”

Performance of various alignment methods and similarity measures in identifying common homologs and/or DS-related homologs. by Chia-Han Chu (124931)

“…See the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013361#s2" target="_blank">RESULTS</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013361#s3" target="_blank">DISCUSSION</a> Sections for explanations of these results. …”

Locations and effect of QTLs detected for dauer larvae formation in response to defined amounts of pheromone. by James W. M. Green (659557)

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study by Bogdan Barz (173139)

“…A 5% difference in the primary structure of the two predominant alloforms, A and A, results in distinct assembly pathways and toxicity properties. …”

Datasheet1_Pre-operative immune cell numbers and ratios are associated with peri-operative adverse outcomes in transfused patients.docx by Michelle Roets (16726413)

“…</p>Results<p>After adjustment, decreased pre-operative lymphocyte numbers and increased neutrophil/lymphocyte ratio (NLR) were associated with increased odds of developing infection; decreased NLR with decreased odds of developing adverse renal outcomes; and decreased lymphocyte numbers with decreased odds of developing adverse cardiovascular outcomes. …”