E137, D158, and S163 residues are likely involved in the coordination of Mg²⁺ ion at the ATP binding site of Rtg2p. by Rafaela Maria Rios-Anjos (4003220)

“…<b>(E)</b> Rtg2p mutations E137A (left panel) and D158A (middle panel) but not S163A (right panel) decrease the replicative lifespan of yeast. …”

Image_2_Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage.TIF by Shu-Hao Miao (14367141)

“…</p>Discussion<p>The increased level of NOX2 in astrocytes contributes to decreased DHFR in endothelial cells, thus aggravating eNOS uncoupling, which is an essential mechanism underlying acute vasoconstriction after SAH.…”

Table_2_Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage.xlsx by Shu-Hao Miao (14367141)

“…</p>Discussion<p>The increased level of NOX2 in astrocytes contributes to decreased DHFR in endothelial cells, thus aggravating eNOS uncoupling, which is an essential mechanism underlying acute vasoconstriction after SAH.…”

SEC demonstrates that the monomeric population of fALS variants is decreased by <i>S</i>-XL6 treatment and that this is associated with reduced aggregation. by Md Amin Hossain (10170815)

Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer by Hannah Johnson (1342596)

“…<b>PPA24</b> (<b>19a</b>) was identified as the most cytotoxic compound with IC₅₀ values in the range of 2.36–6.75 μM in CRC and FOLFOX-resistant CRC cell lines. …”

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) by Kentaro Futatsugi (1399639)

“…The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit <b>1</b> with low lipophilic efficiency (LipE) was optimized through two key structural modifications: (1) identification of the pyrrolidine amide group for a significant LipE improvement, and (2) insertion of a sp³-hybridized carbon center in the core of the molecule for simultaneous improvement of <i>N</i>-glucuronidation metabolic liability and off-target pharmacology. …”

Effects of bFGF on Cx46 and Cx50 in TtT/GF FS cells. by María Leiza Vitale (4287994)

“…Forty eight-49 kDa Cx46 was transiently and significantly increased by 30 min in the presence of bFGF († P<0.03). Cx50 increased after a 2 h incubation period with bFGF (# P<0.02 2 h vs 0 h), then slowly receded to control values by 24h in the presence of bFGF. …”

H₂S-Nampt pathway regulates bioenergetics. by Reiko Sanokawa-Akakura (254909)

Endogenous hydrogen sulfide increases in response to acute damage in cancer cells. by Reiko Sanokawa-Akakura (254909)

H₂S levels and bioenergetic changes in DR cells isolated from tumors. by Reiko Sanokawa-Akakura (254909)

E4orf4 sensitizes cells to killing by drugs inducing DNA damage or replication stress. by Anna Brestovitsky (849835)

“…<p>Clone 13 cells were induced with Dox for two hrs to stimulate E4orf4 expression (+E4orf4), or were left uninduced (-E4orf4), and were then treated with 4 μM HU or 2.5 ng/ml NCS for three hrs or left untreated (Control). …”

Decreased Paneth cell number and the presence of granulomas differentiate HbTg from Tg animals at 10 days post Tg infection. by Edina K. Szabo (3160332)

Effect of withanone and withaferin A purified from WSWE on <i>S</i>. <i>globosa</i> cells. by Acharya Balkrishna (5640038)

H₂S increases ECAR, ATP, NAD⁺ and Nampt in a dose-dependent manner in cancer cells. by Reiko Sanokawa-Akakura (254909)

Changes in glycolysis and bioenergetics in DR cells. by Reiko Sanokawa-Akakura (254909)

V2 vasopressin receptor abundance. by Sophie Constantin Lütken (689916)

“…Immunoblot was reacted against anti-V2R protein and revealed a single band at ~ 47 kDa (<i>A-E</i>). …”

Pull down assay of RhoA. by Frank Roloff (695802)

“…Molecular weight of stained protein bands corresponds to about 20 kDa as reported for RhoA. (B) Relative RhoA level was decreased to approximately 50% of control after Ibuprofen treatment whereas RhoA level after LPA treatment was increased to 200% of control. …”

Immunoprecipitation of PfCullin-2. by Zeba Rizvi (18071564)

Subjects:

Elimination of persistent <i>P</i>. <i>c</i>. <i>chabaudi</i> infection decreases memory T cell numbers in <i>Icos</i>^-/- mice. by Leah E. Latham (8781863)

RhoA and Rho kinase inhibitors promote initiation of neurites. by Frank Roloff (695802)