Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling - Fig 8 by Daijiro Hori (3850915)

Schematic explaining ORF classification as recoding or non-recoding. by Natalie E. Baggett (3841381)

TGF-β1 and Mut TGF- β1 3'-UTR Primers. by Daijiro Hori (3850915)

Overview of laryngeal and upper tracheal anatomy. by Caterina Zagona-Prizio (14833699)

Regulation of USP2a and MDM2 in response to <i>as-</i>APF. (A by Jayoung Kim (153487)

“…Western blot with anti-USP2a antibody showed that the level of USP2a level was stably decreased in response to <i>as</i>-APF treatment, but this was only transiently reduced by control mock APF peptide. …”

OGD in lG partly preserves Δψ_m (i.e. delays depolarization) caused by subsequent NaN₃ treatment. by Andrej Korenić (529339)

“…Depolarization is visible in the normoxic group (b, c) (seen as concentration-dependent decrease in magenta and increase in blue color), but it is more pronounced than in OGD group after treatment with NaN₃ (e, f). …”

miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions by Eva Maria Pinatel (506111)

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling - Fig 6 by Daijiro Hori (3850915)

Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis by Benjamin Birkner (8212203)

“…We compared continuing treatment (standard care) to a tapering approach (i.e., an immediate 50% dose reduction), withdrawal (i.e., an immediate 100% dose reduction) and tapering followed by withdrawal of bDMARDs. …”

DNMT1 reduces cisplatin sensitivity partially through downregulating FOXO3a in ovarian cancer cells by Chong Guo (5819105)

“…Knocking down of DNMT1 could decrease the IC₅₀ of cisplatin. Treatment with cisplatin may reduce FOXO3a expression in OC cells. …”

Effect of Oxidative Phosphorylation Inhibitors on <i>In Vivo</i> Tat Transport and Sensitivity of Fluorescence Detection on Plates. by Umesh K. Bageshwar (2271628)

“…The SsrA tag decreased the mCherry fluorescence intensity (II; 63±14%), consistent with a decrease in cytoplasmic mCherry concentration due to SsrA-dependent degradation. …”

Density plots (A) and restricted cubic splines (B) of the associations of 1-year change (%) in weight and waist circumference after diabetes diagnosis with incident remission of ty... by Hongjiang Wu (449543)

Image_1_Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.TIF by In-Young Choi (3025167)

Image_2_Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.TIF by In-Young Choi (3025167)

Immunocontraceptive target repertoire defined by systematic identification of sperm membrane alloantigens in a single species by Nathaly Cormier (4775262)

“…Less abundant alloantigens included ATP synthase F1 β subunit, myo-inositol monophosphatase-1, and zymogen granule membrane glycoprotein-2. Immunodominant sperm lipid raft alloantigens included SAMP14, lymphocyte antigen 6K, and the epididymal sperm protein E12. …”

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling - Fig 7 by Daijiro Hori (3850915)

Simulations for a high restoration coefficient <i>ν</i> = 0.8. by Fernando Córdova-Lepe (9727230)

Simulations for a medium restoration coefficient <i>ν</i> = 0.5. by Fernando Córdova-Lepe (9727230)

Parasite control and histopathology (lung) are similarly impaired in complete and cDC-specific <i>Bcl3</i>-deficient mice infected with <i>T</i>. <i>gondii</i>. by June Guha (14041154)