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181
Statistically significant correspondence between human psoriasis and mouse psoriasiform phenotypes: Proportion of psoriasiform-increased to psoriasiform-decreased transcripts.
Published 2011“…Likewise, we identified 533 transcripts with significantly decreased expression in human psoriasis (FDR-adjusted P<0.05 and log<sub>2</sub>-transformed fold-change estimate less than 1.00 in absolute value), and these transcripts were associated with 709 transcripts derived from orthologous mouse genes. …”
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182
Breast Cancer 1 (BrCa1) May Be behind Decreased Lipogenesis in Adipose Tissue from Obese Subjects
Published 2012“…Consistent with its role limiting fatty acid biosynthesis, both <em>BrCa1</em> mRNA (3.5-fold, p<0.0001) and protein (1.2-fold, p = 0.001) were increased in pre-adipocytes, and decreased during <em>in vitro</em> adipogenesis, while P-ACC decreased during differentiation of human adipocytes (p = 0.005) allowing lipid biosynthesis. …”
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183
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase‑1
Published 2018“…The crystal structure of DNMT1 was determined in two different states in which the helix that follows the catalytic loop was either kinked (designated helix-kinked) or well folded (designated helix-straight state). …”
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184
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Inhibition of histone methyltransferase EZH2 in <i>Schistosoma mansoni in vitro</i> by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication...
Published 2018“…</p><p>Methodology/Principal findings</p><p>Adult male and female worms and schistosomula were treated with different concentrations of GSK343 for up to two days <i>in vitro</i>. Western blotting showed a decrease in the H3K27me3 histone mark in all three developmental forms. …”
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186
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Rdh10a deficient embryos have decreased expression of RA signaling responsive genes.
Published 2015“…<p>(A-F) ISH for <i>cyp26a1</i>, <i>hoxb5b</i>, <i>and dhrs3a</i> expression in control sibling and Rdh10a deficient embryos. …”
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A flow diagram of the study entry.
Published 2025“…Criteria included: at least six months’ residency before death, ability to eat orally during the study period, and death within the facility. We created a time-series dataset for 69 participants, documenting their average weekly food intake (on a scale of 0-10). …”
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dMi-2 decreases the stability and extent of cohesin chromosome binding.
Published 2012“…<p>(A) FRAP recovery curves for EGFP-Smc1 in wild-type salivary gland nuclei, and salivary gland nuclei in which <i>da-GAL4</i> drives the expression of two <i>UAS-dMi-2<sup>+</sup></i> transgenes (<i>EGFP-Smc1 da-GAL4/UAS-dMi-2<sup>+</sup> 3-3; UAS-dMi-2<sup>+</sup> 15-1/+</i>) at 25°C. …”
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