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<i>Kdm6a</i> conditional KO mice have decreased repopulating potential in serial competitive transplantation assays.
Published 2021“…Significant differences in the chimerism of SLAM cells compared to whole BM were found in KO-F mice (55.2-fold increase in CD45.2<sup>+</sup> KO-F SLAM cells as compared to CD45.2<sup>+</sup> cells in the whole BM, p = 0.0163) and KO-M mice (11.31-fold increase in CD45.2<sup>+</sup> KO-M SLAM cells as compared to CD45.2<sup>+</sup> cells in the whole BM, p = 0.0010). …”
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Loss of ATXN3 is associated with decreased levels of HDAC3 and NCoR in MEFs.
Published 2018“…(B) Semiquantitative analysis shows the decrease in HDAC3 and NCoR in <i>Atxn3</i>-KO cells. …”
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Marimastat decreases hepatic stellate cell (HSC) activation, but increases recruitment of inflammatory cells.
Published 2013“…Liver sections from animals that were chronically challenged with CCl4 showed that resident T cells (CD3, C,D) and macrophages (F4/80, E,F) counts increased up to 2-fold upon Marimastat treatment. Oil, non-fibrotic control group; CCl4, fibrotic mice; VEH, vehicle treated control group; MAR, Marimastat treated experimental group; α-SMA, alpha-smooth muscle actin; *, P<0.05; **, P<0.01; ***, P<0.001 vs. vehicle alone. …”
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