Inhibition of <i>de novo</i> lipogenesis decreases intracellular HCV RNA. by Sowmya Narayanan (2826308)

CAK inhibition decreases gene transcription after UV-induced DNA damage. by Hany H. Arab (364331)

COG annotation of differentially abundant proteins of three genotypes of <i>Lolium perenne</i> (fold increase>1.5, fold decrease<0.5, <i>P</i> < 0.05). by Fatemeh Raeisi Vanani (8991491)

Assessment of the viability of DFATs within the vocal fold muscle using GFP immunostaining. by Ikuo Mikoshiba (9312007)

Subjects:

Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom <i>Thalassiosira pseudonana</i> - Fig 2 by Johanna A. L. Goldman (7372724)

Effect of the universal nuclease on various concentration of infectious intact FCoV viruses. by Finja Rausch (14352176)

Subjects:

T cell TNF-α responses from two RC participants over time and comparisons of RC participants’ SARS-CoV-2-specific T cells based on time of sample collection. by Katherine M. Littlefield (12647420)

Subjects:

Pre-treatment of IOZCAS-Spex-II cells with CPT and HCPT decreased Topo1 specific activity in a dose-dependent manner. by Lan Zhang (90951)

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter by Laura László (3221631)

“…Still, there has been no reliable molecular model available for this protein, as the published structures of other ABC transporters could not be properly fitted to the ABCG2 topology and experimental data. The recently published high resolution structure of a close homologue, the ABCG5-ABCG8 heterodimer, revealed a new ABC transporter fold, unique for ABCG proteins. …”

Knock-down of endogenous p66α or p66β decreases MBD2-mediated repression by Marc Brackertz (27647)

PDGF-BB maintains Bcl2/Bax ratio and decreases caspase-3 activation induced by Tat and morphine. by Shaily Malik (226661)

“…(B) Densitometric analysis of the blots shown in (A). Tat and morphine together resulted in a significantly decreased ratio of Bcl2/Bax, indicating cell's progress towards apoptosis. …”

<i>Ex vivo</i> deletion of <i>sirt1</i> decreases expression of RUNX2 downstream targets. by Kayvan Zainabadi (502381)

“…<b>C)</b> While SIRT1 knockout osteoblasts (Cre) express comparable amounts of Runx2, they show a near two-fold reduction in the expression of the Runx2 downstream target, <u>Osterix</u> (Osx). …”

Binding of <i>PC3/Tis21</i> to the <i>Id3</i> promoter and corresponding decrease of <i>Id3</i> mRNA. by Stefano Farioli-Vecchioli (256006)

“…(<b>A</b>) PC12 cells without (white columns) or with expression of exogenous <i>PC3</i> (activated a week before by withdrawal of 2 µg/ml of doxycycline; grey columns) were exposed to NGF (100 ng/ml) for 1 and 48 hours. …”

Maternal Hypoxia Decreases Capillary Supply and Increases Metabolic Inefficiency Leading to Divergence in Myocardial Oxygen Supply and Demand by David Hauton (341981)

“…Hearts of male offspring subjected to Maternal Hypoxia showed a 20% decrease in cardiac output (<i>P</i><0.05), despite recording a 2-fold increase in glucose oxidation (<i>P</i><0.01) and 2.5-fold increase (<i>P</i><0.01) in palmitate oxidation. …”

A New Rotane Family:  Synthesis, Structure, Conformation, and Dynamics of [3.4]-, [4.4]-, [5.4]-, and [6.4]Rotane¹ by Lutz Fitjer (2466634)

“…All syntheses are based on bicyclobutylidene (<b>9</b>):  [2+1] cycloaddition of cyclobutylidene yields [3.4]rotane (<b>5</b>) (<b>9</b>−<b>5</b>), [2+2] cycloaddition of trimethyleneketene followed by spiroalkylation of the resulting trispiroketone <b>10</b> yields [4.4]rotane (<b>6</b>) (<b>9</b>−<b>10</b>−<b>13</b>−<b>14</b>−<b>6</b>), homologization of <b>10</b> via β-hydroxy selenides gives access to tetraspiroketone <b>11</b> and pentaspiroketone <b>12</b> (<b>10</b>−<b>15</b>−<b>11</b>−<b>16</b>−<b>12</b>), and further elaboration directed toward a cyclopropylcarbene−cyclobutene rearrangement yields [5.4]rotane (<b>7</b>) and [6.4]rotane (<b>8</b>) [<b>11</b>(<b>12</b>)−<b>18</b>(<b>24</b>)−<b>19</b>(<b>25</b>)−<b>20</b>(<b>26</b>)−<b>21</b>(<b>27</b>)−<b>22</b>(<b>28</b>)−<b>23</b>(<b>29</b>)−<b>7</b>(<b>8</b>)]. …”

FXR decreases in mice livers with pathological injuries induced by <i>S</i>. <i>japonicum</i> infection. by Beibei Zhang (509356)

Summary of the A19D unfolding pathway highlighting the main structural changes identified here that might explain its decreased thermodynamic stability. by Priscila Ferreira (498747)

Markedly decreased sensitivity of HIV entry to gp120 directed inhibitors during cell-cell transmission. by Irene A. Abela (173068)

VEGF mutants demonstrated increased VE-cadherin expression compared to littermates, while sFlt-1 mutants demonstrated decreased expression. by Christopher R. Schlieve (3179439)