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Significant decrease of SMAD4 protein in DBA iPSCs.
Published 2015“…A) Slight decrease of mRNA level of <i>SMAD4</i> in the DBA iPSCs with <i>RPS19</i> or <i>RPL5</i> mutations. …”
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Decreased biomechanical stability of bones from <i>Col1a1-Krm2</i> transgenic mice.
Published 2013“…(D) Cortical thickness (C.Th.) and bone mineral density (vBMD) are decreased in <i>Col1a1-Krm2</i> transgenic mice compared to wildtype littermates. …”
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1209
A R13A point mutation in C4 attenuates CLCuMuV infection.
Published 2018“…<b>(C)</b> The mutant CLCuMuV carrying C4<sup>R13A</sup> (CLCuMuV-C4<sup>R13A</sup>), which contains a R13A mutation in <i>C4</i>, showed the decreased viral symptom compared to wild type CLCuMuV. …”
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Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects
Published 2023“…Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …”
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Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects
Published 2023“…Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …”
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Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects
Published 2023“…Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …”
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Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel
Published 2020“…The kinetics of reaction of O<sub>2</sub> with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O<sub>2</sub> binding >25000-fold without altering the component affinity. …”
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1214
Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel
Published 2020“…The kinetics of reaction of O<sub>2</sub> with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O<sub>2</sub> binding >25000-fold without altering the component affinity. …”
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