<b>Metabolic Improvements with Tirzepatide in Lipodystrophy: A Novel Option?</b> by Rasimcan Meral (5022425)

“…Results: Seventeen patients received tirzepatide, 14 with FPLD (ages within 30-74 years; 12 female 2 male). After a median 8.7 months of follow-up, BMI (medianΔ -1.7; range -5.9 to 0.9 kg/m2; p=0.008), HbA1c (medianΔ -1.1%; range -6.3 to -0.1%; p<0.001), triglycerides [medianΔ -65 mg/dL (-0.73 mmol/L); range -3820 to 43 mg/dL (-43.2 to 0.49 mmol/L); p=0.003] and total daily insulin requirements (medianΔ -109; range -315 to 0 units/day; p=0.002) were significantly reduced. …”

The Fn-FRET probe reveals a steep gradient of fibronectin conformations. by Jasper Foolen (3088503)

“…Values correspond to FRET ratios for fibronectin in solution progressively denatured by GdnHCl, as depicted in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160369#pone.0160369.s005" target="_blank">S5 Fig</a>. …”

Efficacy and Safety of Adalimumab in Patients with Behçet Uveitis: A Systematic Review and Meta-Analysis by Hidayet Sener (14372733)

“…In addition, ADA therapy resulted in decreased grade of intraocular inflammation [std diff, −1.187 (95%CI: -1.508, -0.866)] and macular thickness [std diff, −0.564 (95%CI: -0.843, -0.286)] and caused a decrease in CS dosage [std diff, −1.809 (95%CI: -2.420, -1.198)]. …”

Supplementary Material for: Arteriovenous Access Monitoring with Ultrasound Dilution in a Pediatric Hemodialysis Unit by Ashoor I.F. (4149550)

“…<b><i>Conclusions:</i></b> A noninvasive UD screening algorithm of AV access flow is very sensitive in detecting hemodynamically significant stenosis and can decrease AV access thrombosis rates.…”

Table_2_Associations between repetitive head impact exposure and midlife mental health wellbeing in former amateur athletes.docx by Claire V. Buddenbaum (18622372)

“…The contact group exhibited a 2.25-fold higher likelihood of being diagnosed with mental health disorders and 1.29-fold higher likelihood of using associated medications compared to the non-contact group. …”

Heat map of correlation between intestinal flora, SCFAs, hormones, and inflammation in POI rats after PMSC treatment. by Shudan Liu (7049483)

Mapping Mangrove Extent and Change: A Globally Applicable Approach - Dataset by nathan thomas (4016780)

“…It is recommended that mangrove baselines are updated on at least a 5-year interval to suit the requirements of policy makers.…”

Triptorelin: A Review of its Adjuvant Use in Early Breast Cancer by James Frampton (5030771)

“…This indication reflects the results of the 5-year SOFT and TEXT studies, especially SOFT, in which ovarian function suppression (OFS; mainly achieved with triptorelin) added to tamoxifen provided a significant benefit in the overall study population of premenopausal patients only after adjusting for prognostic factors. …”

Ameliorating role of co-administration of granulocyte colony stimulating factor and sodium bicarbonate on the skeletal muscle of a rat model of chronic kidney disease (A histologic... by Fayza E. Ahmed (20487163)

“…The CKD group revealed a significant increase in MDA and TNF-α. Furthermore, features of renal injury, muscle degenerative changes, increased collagen and decreased CD34 and myogenin expression were observed. …”

Supplementary Material for: Severe Hypertriglyceridemia Induced by Docetaxel: A Novel Case Report by Saito Y. (4141705)

“…The mechanism underlying the symptoms remains unclear; we speculate that it could be a resultant of a decrease in lipid metabolism as the patient had grade 2 diarrhea. …”

SUMO-dependent disruption of SET-26 complex formation. by Cátia A. Carvalho (20513858)

“…(<b>B</b>) A volcano plot depicting the differentially enriched proteins bound to SET-26::GFP in WT versus an excess of SUMOylation backgrounds; the cut-off values used were FDR > 1.3 (-log10) and fold change>|1.1| (log2). The numerical data presented can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002980#pbio.3002980.s014" target="_blank">S4 Table</a>. …”

Late chronic DCS treatment has no effect on anxiolytic-like behavior or hypoactivity in adult <i>Grin2b</i>^{<i>+/C456Y</i>} mice. by Wangyong Shin (6793040)

Diagram of EC growing states and AFM probing. by Leike Xie (1317108)

Image_2_Metabolomic Profiling of Dongxiang Wild Rice Under Salinity Demonstrates the Significant Role of Amino Acids in Rice Salt Stress.pdf by Yaling Chen (713903)

“…A total of 90 metabolites were significantly changed (49 upregulated and 41 downregulated) under salinity, of which the largest increase was in DL-2-Aminoadipic acid (27.08-fold) and the largest decrease was in L-Carnitine (0.014-fold). …”

Table_2_Metabolomic Profiling of Dongxiang Wild Rice Under Salinity Demonstrates the Significant Role of Amino Acids in Rice Salt Stress.xlsx by Yaling Chen (713903)

“…A total of 90 metabolites were significantly changed (49 upregulated and 41 downregulated) under salinity, of which the largest increase was in DL-2-Aminoadipic acid (27.08-fold) and the largest decrease was in L-Carnitine (0.014-fold). …”

A working model integrating embryo-dependent (top panel) and -independent (bottom panel) programming of endometrial function 7 days after estrus. by Mariana Sponchiado (839738)

“…<i>Embryo-independent signaling</i>: (4) upregulation of the anti-adhesive <i>MUC1</i> stimulates transit of the embryo from the UTJ to the more caudal regions of the uterine horn; (5) upregulation of vasodilatation-related gene (<i>PTGIS</i>) and downregulation of vasoconstriction-related gene (<i>EDN3</i>) indicate greater blood flow to the apical regions of the horn; (6) increase of solute transport (<i>SLCO2A1</i>); (7) downregulation of genes associated with cellular proliferation (<i>IGF1</i>, <i>IGF2</i>, <i>IGF1R</i> and <i>IGF2R</i>), suggests a change in tissue function to promote (8) synthesis of embryotropins (<i>FGF2</i>) and (9) secretion, which is supported by upregulation of glandular secretions-related gene (<i>GRP</i>); (10) decrease of extracellular matrix remodeling (<i>MMP14</i>, <i>MMP19</i>, <i>MMP2</i> and <i>TIMP3</i>). …”

Image2_IRE-1 endoribonuclease activity declines early in C. elegans adulthood and is not rescued by reduced reproduction.TIFF by Evandro A. De-Souza (9710284)

Deterministic transitions have a different signature than stochastic ones. by Martin L. L. R. Barry (17996434)

“…The transition to stimulus ‘0’, <i>T</i>_7→0 = 1, is deterministic (yellow square, lower left corner) under rule A but stochastic with a value of <i>T</i>_4→0 = 0.5 (light blue) under rule B, and vice versa for the transitions stimulus ‘4’.…”

Antiviral activity of RDV and EIDD2801against NSP6 and NSP12 mutant viruses. by Agnieszka M. Szemiel (10196243)

Data_Sheet_1_Associative role of HLA-DRB1 as a protective factor for susceptibility and progression of Parkinson’s disease: a Chinese cross-sectional and longitudinal study.DOCX by Raoli He (10321573)

“…</p>Results<p>In the case–control study, HLA-DRB1 rs660895-G allele was associated with a decreased risk of PD in allele model (adjusted OR=0.72, p = 0.003) and dominant model (AG + GG vs. …”