Highly and rarely activated <i>var</i> genes. <i>var</i> gene were sorted by their relative mRNA levels to the total <i>var</i> transcript of the entire family, at each time point... by Yair Fastman (175460)

“…Comparison of overall upsA transcript levels between the first 4 time points and the last 5 time points shows significant decrease in transcription levels of upsA <i>var</i> genes over time (<i>P = 0.007</i>; Mann-Whitney U test (<b>C</b>), <i>var</i> genes that have high probability to be activated. …”

Cytokine changes in supernatants the splenocytes. by Chen Yang (207381)

“…The injection of MSC in the OVA+MSC group conspicuously decreased IL-4, IL-5 and IL-10 levels but increased IFN-γ level. …”

Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer by Qifeng Wang (123379)

“…</p> <h3>Methodology/Principal Findings</h3><p>According to the results of miRNA profiling performed on pooling plasma samples form 10 CRC patients or 10 healthy controls, a panel of miRNAs (hsa-miR-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in CRC plasma with fold changes >5. …”

Age and emplacement of the Permian–Jurassic Menghai batholith, Western Yunnan, China by Elizabeth J. Catlos (3318813)

“…If recorded by syntectonic zircon crystallization, collision and closure of a branch of the Palaeo-Tethyan Ocean occurred here over an ~100 million years time period from the Permian (281.0 ± 13.0 Ma) to Jurassic (171.5 ± 5.4 Ma).…”

Assessment of sesquiterpene lactones isolated from <i>Mikania</i> plants species for their potential efficacy against <i>Trypanosoma cruzi</i> and <i>Leishmania</i> sp. by Laura C. Laurella (469416)

“…Deoxymikanolide presented the highest selectivity index for trypomastigotes (SI = 54) and amastigotes (SI = 12.5). In an <i>in vivo</i> model of <i>Trypanosoma cruzi</i> infection, deoxymikanolide was able to decrease the parasitemia and the weight loss associated to the acute phase of the parasite infection. …”

Baseline predictors of short-term visual outcomes after intravitreal conbercept injection for neovascular age-related macular degeneration by Peng Zhang (2071)

“…Results: After the 6-month treatment, the mean best-corrected visual acuity improved from 1.10 ± 0.42 logarithm of the minimum angle of resolution (logMAR) to 0.41 ± 0.18 logMAR, the mean retinal sensitivity increased from 5.13 ± 0.86 dB to 7.32 ± 1.21 dB, the mean central retinal thickness decreased from 440.38 ± 61.05 μm to 260.01 ± 24.86 μm, and the total number of hyperreflective dots and the number of hyperreflective dots in each retina layer were significantly reduced as compared with those before treatment (all p<0.05). …”

Baseline predictors of short-term visual outcomes after intravitreal conbercept injection for neovascular age-related macular degeneration by Peng Zhang (2071)

“…Results: After the 6-month treatment, the mean best-corrected visual acuity improved from 1.10 ± 0.42 logarithm of the minimum angle of resolution (logMAR) to 0.41 ± 0.18 logMAR, the mean retinal sensitivity increased from 5.13 ± 0.86 dB to 7.32 ± 1.21 dB, the mean central retinal thickness decreased from 440.38 ± 61.05 μm to 260.01 ± 24.86 μm, and the total number of hyperreflective dots and the number of hyperreflective dots in each retina layer were significantly reduced as compared with those before treatment (all p<0.05). …”

Huntingtons Disease Mice Infected with <i>Toxoplasma gondii</i> Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality by David W. Donley (3111198)

“…<div><p>Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-repeat expansion in the huntingtin protein. …”

Subtropical high-montane forest climate refuges in Brazil by Guilherme Neto dos Santos (6721397)

“…The potential area of Crinodendron brasilense Reitz & L.B.Sm. decreased the most, by 82.11 % (RCP 4.5) and 90.06 % (RCP 8.5), respectively. …”

Estimates of air changes per hour (ACH). by Martin S. Zand (623236)

“…The recommended ACH for schools is ≥ 4.0 exchanges of fresh air per hour [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0291840#pone.0291840.ref005" target="_blank">5</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0291840#pone.0291840.ref009" target="_blank">9</a>]. …”

The TMS-induced artifacts before and after skin preparation by puncturing and exfoliation. by Dominik Freche (202618)

“…Both models are least-squares fitted to all traces which do not change sign and have amplitude larger than 1.5 mV (dashed line). All fits are done to 25 ms starting from the point of reaching 1.5 mV. …”

Data Sheet 1_The impact of prudent financial policies on the urban–rural household health expenditure disparity: evidence from China.docx by Wenxin Zou (625953)

“…</p>Results<p>The results show that the regulation significantly affects rural households’ medical expenditures (with a 20.5% decrease in guaranteed investment and a 1.3% increase in out-of-pocket payments), but has no significant impact on urban households. …”

Modeling Tuberculosis Dynamics, Detection and Control in Cattle Herds by Mohammed El Amine Bekara (634795)

“…The median duration of the latent period was estimated 3.5 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108584#pone.0108584-Perez1" target="_blank">[2]</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108584#pone.0108584-delaRuaDomenech2" target="_blank">[8]</a> months. …”

Table 1_Short term heat stress alters the hematological, immunological, and plasma metabolomic responses of Florida Cracker sheep.xlsx by Makenzie Harrison (22152829)

“…The THI for the HT and CTL groups ranged from 81.3 – 89.5 and from 73.5 – 75.6, respectively. The HT group exhibited a significant increase (P < 0.05) in respiratory rate compared to the CTL group. …”

Table_1_Bacterial communities during composting cultivation of oyster mushroom Pleurotus floridanus using broken eggs as the nitrogen source and study of agronomic and nutritional... by Jun Wei (208481)

“…The P3 treatment (initial C/N of 26:1) showed the highest biological efficiency (BE) of 100.19% and a low contamination rate (CR) of 7.00%, while the higher dosage of BEM (P4 and P5) led to a sharp decrease in BE and a sharp increase in CR. …”

Data_Sheet_1_Bacterial communities during composting cultivation of oyster mushroom Pleurotus floridanus using broken eggs as the nitrogen source and study of agronomic and nutriti... by Jun Wei (208481)

“…The P3 treatment (initial C/N of 26:1) showed the highest biological efficiency (BE) of 100.19% and a low contamination rate (CR) of 7.00%, while the higher dosage of BEM (P4 and P5) led to a sharp decrease in BE and a sharp increase in CR. …”

Positive feedback loops and the merged controller sub-network in lesional psoriatic skin. by Máté Manczinger (489725)

“…<p>Individual positive feedback loops with 2, 3 or 4 nodes are shown. Node color is blue if the gene expression is decreased and red if increased. …”

Image_1_Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection.tif by Gerald Mak (10899036)

“…We observed a significant decrease in the CD4 T-cell count of CHI patients in the left colon (p=0.03) and a trend to a decrease in the terminal ileum (p=0.13). …”

DataSheet_1_Trans-population graph-based coverage optimization of allogeneic cellular therapy.xlsx by Sapir Israeli (15415241)

“…We then compared the efficiency of different optimization algorithms – a greedy solution, a linear programming (LP) solution, and integer linear programming (ILP) -- as well as random donor selection (average of 5 random trials) to show that an optimization can be performed at the entire population level.…”

Image_2_Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection.tif by Gerald Mak (10899036)

“…We observed a significant decrease in the CD4 T-cell count of CHI patients in the left colon (p=0.03) and a trend to a decrease in the terminal ileum (p=0.13). …”