Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Mesenchymal stromal cells (MSCs) induce <i>ex vivo</i> proliferation and erythroid commitment of cord blood haematopoietic stem cells (CB-CD34+ cells) by Simone Perucca (3775696)

“…In the presence of MSCs, a significant increase in CD34+ cell number was observed (fold increase = 14.68), mostly in the SN-fraction (fold increase = 13.20). …”

Life Cycle Environmental Impacts of Sewage Sludge Pyrolysis and Their Dynamic Evolution by Jan Matuštík (22500291)

Ball valve pipeline geometric modeling. by Weiqing Xu (1279959)

“…<div><p>Hydrogen is a clean energy source, and blending it with natural gas in existing pipeline networks is a key transition solution for transportation cost reduction. …”

Hydrogen volume fraction change in the pipeline. by Weiqing Xu (1279959)

“…<div><p>Hydrogen is a clean energy source, and blending it with natural gas in existing pipeline networks is a key transition solution for transportation cost reduction. …”

Mesh independence verification. by Weiqing Xu (1279959)

“…<div><p>Hydrogen is a clean energy source, and blending it with natural gas in existing pipeline networks is a key transition solution for transportation cost reduction. …”

Valve parameters and simulation results. by Weiqing Xu (1279959)

“…<div><p>Hydrogen is a clean energy source, and blending it with natural gas in existing pipeline networks is a key transition solution for transportation cost reduction. …”

PV1 treatment ameliorates EAU. by Pedro Henrique Papotto (791904)

Undulation pipeline geometric modeling. by Weiqing Xu (1279959)

“…<div><p>Hydrogen is a clean energy source, and blending it with natural gas in existing pipeline networks is a key transition solution for transportation cost reduction. …”

Increased sensitivity to electroshock in <i>ogt-1; eel-1</i> double mutants is improved with application of GABA receptor agonist Baclofen. by Nirthieca Suthakaran (11731101)

“…<p>Shown are each genotype ran through the electroconvulsive seizure assay for 3 seconds at 47V in Baclofen. (A) The wildtype animals displayed a trending significant decrease in recovery time upon increasing doses of 5mM (n = 14), 10mM (n = 23), and 20mM Baclofen (n = 14), compared to these animals in the sham, M9 saline control group (n = 57). …”

The effect of Hdc depletion in the MZ and the PSC on plasmatocytes and crystal cells. by Bayan Kharrat (19959505)

Influence of Iron Substitution and Solution Composition on Brucite Carbonation by Colton J. Vessey (11282582)

“…Carbonation in anoxic environments led to the formation of Fe­(II)-substituted nesquehonite (MgCO₃·3H₂O) and dypingite [Mg₅(CO₃)₄(OH)₂·∼5H₂O], as well as chukanovite [Fe₂^IICO₃(OH)₂] in the case of 23 and 44 mol % Fe­(II)-brucite carbonation. …”

The predictive efficacy of GSRS in combination with GR and/or HSD11B1 for the prognosis of KIRC patients. by Yu Zhang (12946)

Examples of individual dolphins’ telemetry locations and potential ranging areas from the 2016 and 2017 field efforts. by Ryan Takeshita (3992990)

The effect of <i>Parkia speciosa</i> on gastric tissue glycoprotein-PAS staining in ethanol-induced gastric ulcers in rats. by Rami Al Batran (587060)

Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway by Seung Mook Lim (2267395)

“…Furthermore, knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased (<i>p <</i> 0.05). …”

Time pressure: a controlled experiment of test case development and requirements review by Mika Mäntylä (406301)

“…<div>REF: Mäntylä M. V., Petersen K., Lehtinen, T. O. A., Lassenius, C. …”

Antimycin A has broad spectrum antiviral activity against RNA viruses. by Avi Raveh (493231)

“…</p> <p>(C) Antimycin A activity against SeV. Vero cells were infected with GFP-SeV at the indicated MOI, treated simultaneously with DMSO or 200 nM antimycin A, and GFP fluorescence was measured at 48 hpi (left graph) and 72 hpi (right graph). …”

Lipid Microcapsules Promoted Neural Stem Cell Survival in the Infarcted Area of Mice with Ischemic Stroke by Inducing Autophagy by Rui Xu (158313)

“…Intracerebral transplantation of neural stem cells (NSCs) for ischemic stroke treatment has been demonstrated to be inefficient, with only <5% of delivered cells being retained. Microcapsules may be a good carrier for NSC delivery; however, the current microcapsules do not fully meet the demands for cell survival after transplantation. …”

Lipid Microcapsules Promoted Neural Stem Cell Survival in the Infarcted Area of Mice with Ischemic Stroke by Inducing Autophagy by Rui Xu (158313)

“…Intracerebral transplantation of neural stem cells (NSCs) for ischemic stroke treatment has been demonstrated to be inefficient, with only <5% of delivered cells being retained. Microcapsules may be a good carrier for NSC delivery; however, the current microcapsules do not fully meet the demands for cell survival after transplantation. …”