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a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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1046
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades
Published 2022“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC<sub>50</sub> value of 61 nM compared to that of Tamoxifen (IC<sub>50</sub> value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”
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1047
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades
Published 2022“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC<sub>50</sub> value of 61 nM compared to that of Tamoxifen (IC<sub>50</sub> value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”
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1048
rVλ6Wil fibrils cause oxidative stress in cardiomyocytes without a decrease in cellular ATP.
Published 2015“…<p>(A) After a 2 h incubation with rVλ6Wil fibrils or monomer, cellular ATP levels, as detected by luminescence (black bars), were not significantly reduced relative to the PBS-treated control. …”
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1049
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1050
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1051
Gene expression profile of <i>Pcgf5</i>-deficient HSPCs.
Published 2016“…(D) Venn diagram showing the overlap between genes (listed in gene symbol) up-regulated in LSK cells from <i>Pcgf5</i><sup><i>Δ/Δ</i></sup>, <i>Ezh2</i><sup><i>Δ/Δ</i></sup> [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154561#pone.0154561.ref018" target="_blank">18</a>], and <i>Bmi1</i> KO [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154561#pone.0154561.ref019" target="_blank">19</a>] mice (≥2.0-fold compared with the WT control, respectively). …”
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1052
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1053
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A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization-5
Published 2011“…<p><b>Copyright information:</b></p><p>Taken from "A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization"</p><p>BMC Cardiovascular Disorders 2007;7():4-4.…”
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1056
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