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Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors
Published 2017“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”
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165
Mean decrease in accuracy (MDA) of top 15 urine metabolites.
Published 2020“…Urine metabolites with a mean decrease in accuracy ≥ 0.004 in at least one post-treatment time point (2–5) were considered for inclusion in the predictive model.…”
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We cannot be “forever young,” but our children are: A multilevel intervention to sustain nursery school teachers’ resources and well-being during their long work life cycle
Published 2018“…The third solution differed between groups: environmental redefinition (for group one); gymnastic and vocal hygiene (for group two). We hypothesized that the interventions improve teachers’ work abilities, increase well-being, and decrease stress and burnout. …”
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PDGF-BB maintains Bcl2/Bax ratio and decreases caspase-3 activation induced by Tat and morphine.
Published 2011“…(B) Densitometric analysis of the blots shown in (A). Tat and morphine together resulted in a significantly decreased ratio of Bcl2/Bax, indicating cell's progress towards apoptosis. …”
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Maternal Hypoxia Decreases Capillary Supply and Increases Metabolic Inefficiency Leading to Divergence in Myocardial Oxygen Supply and Demand
Published 2015“…Hearts of male offspring subjected to Maternal Hypoxia showed a 20% decrease in cardiac output (<i>P</i><0.05), despite recording a 2-fold increase in glucose oxidation (<i>P</i><0.01) and 2.5-fold increase (<i>P</i><0.01) in palmitate oxidation. …”
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The proportional decrease in chamber area with depth of nests is similar no matter what the colony size
Published 2011“…Open access; copyright is maintained by the authors.</p> Every 10-fold increase in depth is associated with a 75% decrease in summed chamber area in the decile (note log-log scale). …”
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Resveratrol decreased intracellular levels of R5P.
Published 2013“…<p>R5P is a pentose phosphate pathway intermediate, an important marker for anabolism (nucleotide biosynthesis). …”
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Decreased Tks5 expression results in neural crest-derived defects.
Published 2011“…<p>(A–B) Melanophores within the trunk region above the yolk sac extension in control MO-injected and Tks5 MO-injected embryos were qualitatively (A) and quantitatively (B) analyzed. n = 15 embryos and SEM is shown by bar. p values obtained from Student's t-test. ** denotes p<0.01. …”