Spike mutations within variants of concern. by Chris Davis (647632)

Subjects:

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

25OHD₃ increases expression of TRPV6 and Calbindin-D9k in duodenum of CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)

25OHD₃ does not induce vascular calcification in CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)

25OHD₃ restores calcium and PTH levels in CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)

The effect of 25OHD3 on the expression of renal PMCA1b and NCX1 in CYP27B1^+/+ and CYP27B1^-/- mice. by Noelia Torremadé (3687523)

25OHD₃ increases expression of CalbindinD-28K in the kidneys of CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)

Sustainable Production of Polyamide 6 Fibers: Direct Melt Spinning and Efficient Reuse of Residual Oligomers during Polymerization by Shengming Zhang (14662719)

Subjects:

rVλ6Wil fibrils cause oxidative stress in cardiomyocytes without a decrease in cellular ATP. by Helen P. McWilliams-Koeppen (116503)

“…<p>(A) After a 2 h incubation with rVλ6Wil fibrils or monomer, cellular ATP levels, as detected by luminescence (black bars), were not significantly reduced relative to the PBS-treated control. …”

Declining trend in the initial SARS-CoV-2 VL in hospitalized patients coinciding with a decrease in mortality rates. by Said El Zein (11442413)

Two different <i>Hmr</i> mutations interfere differently with HMR interactome and HMR complex formation. by Andrea Lukacs (3752956)

PNNs decrease after EE. (A–D₁) PNNs, stained by WFA (red), enwrap DCN projection neurons, labeled by SMI32 antibodies (blue). by Simona Foscarin (231429)

Pharmacological characterization of WT BMP9 and A347E variant <i>in vitro</i> and <i>in vivo.</i> by Tobias G. Schips (21799838)

Depletion of EphA3 or EphA4 recovers the decreased ERK and Akt activation and lytic gene expression in RNF5 KO PEL cells. by Xiaojuan Li (351842)

Botulinum toxin A (3.5 U/kg) decreases mechanical allodynia induced by IoNC- injury in rats. by Boris Filipović (336089)

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-5 by Hong Yang (37298)

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization-5 by Chandrashekhar D Kamat (60176)

“…<p><b>Copyright information:</b></p><p>Taken from "A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization"</p><p>BMC Cardiovascular Disorders 2007;7():4-4.…”

Expression of genes encoding proteins involved in protein folding, quality control, trafficking and ER-associated degradation differentially expressed in liver of <i>Fmo5</i><sup><... by Ian R. Phillips (5074121)

Statistically significant union pathways refer to the miRNAs with a decreased expression on day 1. by Morgana Lüdtke Azevedo (15285409)