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Retigabine and ML213 decrease the constriction tone of human detrusor strips.
Published 2015“…<p>(A) The original DSM tension recordings illustrate the relaxatory effect of retigabine and ML213, which are K<sub>v</sub>7.2–7.5 and K<sub>v</sub>7.2/7.4/7.5 channel activators, respectively. …”
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Four-fold decrease in [H<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −18 mV at both low and high glutamate concentrations.
Published 2015“…Arrows show GLT-1a E<sub>rev</sub> shifts. <b>(C)</b> Average GLT-1 E<sub>rev</sub> shifts at 37.5 μM and 600 μM are approximately equal when [H<sup>+</sup>]<sub>e</sub> was decreased from 40 to 10 nM.…”
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Four-fold decrease in [K<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by +22 mV at both low and high glutamate concentrations.
Published 2015“…Arrows show GLT-1a E<sub>rev</sub> shifts. <b>(C)</b> Average GLT-1 E<sub>rev</sub> shifts at 37.5 μM and 600 μM are approximately equal when [K<sup>+</sup>]<sub>e</sub> was decreased from 44 to 11 mM.…”
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HRMECs treated with 3-Deazaneplanocin A (DZNep) chemical inhibitor demonstrated increased miR-200b and decreased VEGF expression.
Published 2015“…[NG = 5mM D-glucose, HG = 25mM D-glucose, NG+DMSO = 5mM D-glucose + 0.05% DMSO, HG+DMSO = 25mM D-glucose + 0.05% DMSO, NG+DZNEP = 5mM D-glucose + 5μM DZNep, HG+DZNEP = 25mM + 5μM DZNep; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to β-actin for VEGF and U6 for miR-200b, expressed as a fold change of NG].…”
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FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells.
Published 2019“…(B) Following 24 hours of treatment with FTY720, the proliferation of HuH6 cells measured using the CellTiter 96 cell proliferation assay was significantly decreased (IC<sub>50</sub> = 6.4 μM, p ≤ 0.05). (C) HuH6 cells were plated and allowed to reach 80% confluence, at which time the media was changed for fresh media (0, 5, or 8 μM FTY720) and a standard scratch wound was made. …”
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Fold decrease in virulence gene expression of <i>Salmonella in vivo</i> and <i>in vitro</i><sup>a</sup>.
Published 2014“…Values were expressed as mean ± standard error. The fold-change of target gene was analyzed using the 2<sup>−ΔΔCt</sup> method. …”
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