(A-B) Lead structure for the mechanism-based suicide-inhibitor of Dnmt1. by Vedran Miletić (3918584)

“…Tetrahedral tertiary amine linker is chosen as a flexible structure that can mimic the transition state structure (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174410#pone.0174410.g001" target="_blank">Fig 1</a>). 1-methyl-pyrmidine-2-one was chosen as the target base ring instead of cytosine, to avoid problems with deamination at carbon 4 and to decrease polar surface on the target base ring [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174410#pone.0174410.ref019" target="_blank">19</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174410#pone.0174410.ref022" target="_blank">22</a>]. …”

Qsp1 regulation of binding of Cqs2, Nrg1, and Liv3 to promoters correlates with a change in expression. by Diana K. Summers (9402313)

“…C) Heatmap of genes that are differentially bound by all three TFs Cqs2, Liv3, or Nrg1, and their respective log2-fold expression difference in <i>qsp1Δ</i> compared to wild type. …”

Fig 4 - by Gary Kwok Cheong Lee (8061035)

Mmp14a knockdown minimally affects overall embryonic morphogenesis. by Els Janssens (104451)

“…<b>C</b> RT-PCR analysis of Mmp14a-splice MO injected embryos reveals efficient splice blocking, resulting in a dose-dependent increase in aberrantly spliced <i>mmp14a</i> mRNA (345 bp band) and a concomitant decrease in correctly spliced <i>mmp14a</i> mRNA (168 bp band). …”

A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia by Aaron D. Schimmer (150194)

“…Obatoclax was increased to 45 mg/day (3 h×3 d) if ≤1 patient had a dose-limiting toxicity (DLT) and decreased to 20 mg/day (3 h×3 d) if DLT occurred in ≥2 patients. …”

IHC shows the increased level of fibronectin found in the interstitium of UUO compared to contralateral kidneys was significantly reduced with PEG-FUD treatment. by Bianca R. Tomasini-Johansson (5892587)

The polyP pseudo-capsule is detected on BG27 clinical isolate and it is impaired by the <i>ppk1</i> gene deletion. by Benedetta Manca (15810991)

Overdiagnosis and overtreatment of thyroid cancer: A population-based temporal trend study by Sabrina Jegerlehner (4110049)

“…The incidence of early stages increased sharply, the incidence of advanced stages increased marginally, and the mortality from thyroid cancer decreased slightly. There was a three- to four-fold increase in the age-standardized annual thyroidectomy rate in both sexes.…”

Immunohistochemical examination of NF-kβ p65 in liver tissue. by Rasha E. Mostafa (11767721)

Reduced Parasite Motility and Micronemal Protein Secretion by a p38 MAPK Inhibitor Leads to a Severe Impairment of Cell Invasion by the Apicomplexan Parasite <i>Eimeria tenella</i> by Françoise I. Bussière (692733)

“…We next determined whether SB203580 has a direct effect on the parasite. Indeed, parasite motility and secretion of micronemal proteins (EtMIC1, 2, 3 and 5) that are involved in cell invasion were both decreased in the presence of the inhibitor. …”

Evaluation of a Laparoscopic Multi-approach Training for Obstetrics and Gynecology Residents by Débora Davalos Albuquerque Maranhao (10459994)

Water temperature affects aggressive interactions in a Neotropical cichlid fish by Manuela L. Brandão (5021027)

Impact of vaginal estriol on serum hormone levels: a systematic review by A. Kolokythas (7930982)

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers by Ilze Elbere (3584057)

“…One week long treatment with metformin was associated with a significant decrease in the families <i>Peptostreptococcaceae</i> and <i>Clostridiaceae</i>_1 and four genera within these families.…”

Data_Sheet_1_“Alexa, You're Really Stupid”: A Longitudinal Field Study on Communication Breakdowns Between Family Members and a Voice Assistant.PDF by Lina Mavrina (12006440)

“…With regards to the long-term aspect of the study, use of repetition as a repair strategy by both children and adults significantly decreased with time, no other changes were found for other strategies. …”

Data_Sheet_1_Impact of the COVID-19 Pandemic on the Effectiveness of a Metabolic Health Telemedicine Intervention for Weight Loss: A Propensity Score Matching Analysis.pdf by Shaminie J. Athinarayanan (6803186)

“…</p>Methods<p>A total of 746 patients with a BMI ≥25kg/m², enrolled between January and March 2020 and treated for at least 1 year with the NKI, were classified as pandemic cohort (PC). …”

Data_Sheet_2_“Alexa, You're Really Stupid”: A Longitudinal Field Study on Communication Breakdowns Between Family Members and a Voice Assistant.PDF by Lina Mavrina (12006440)

“…With regards to the long-term aspect of the study, use of repetition as a repair strategy by both children and adults significantly decreased with time, no other changes were found for other strategies. …”

Trends in use of prescription stimulants in the United States and Territories, 2006 to 2016 by Brian J. Piper (412361)

“…</p><p>Results</p><p>Amphetamine use increased 2.5 fold from 2006 to 2016 (7.9 to 20.0 tons). …”

DataSheet1_The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial.docx by Boyan Liu (3824863)

“…Meanwhile, the H₂-O₂ intervention significantly decreased diastolic nighttime ambulatory blood pressure by 2.7 ± 6.5 mmHg (p < 0.05). …”

Data_Sheet_1_Serum creatinine/cystatin C ratio as a muscle mass evaluating tool and prognostic indicator for hospitalized patients: A meta-analysis.docx by Wen-He Zheng (10208237)

“…Objective<p>Sarcopenia is a syndrome of decreased muscle mass and deficits in muscle strength and physical function. …”