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DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles.
Published 2013“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”
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Fenretinide decreases levels of PAX3/FOXO1 and its target genes in aRMS cell lines.
Published 2013“…<p>Rh4 and RMS13 cells were treated for 24 hours (A) and 48 hours (B) with different concentrations of fenretinide (0.5–1–5 µM, as indicated). …”
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UNC-62 RNAi decreases expression of collagen genes and increases expression of intestinal genes.
Published 2013“…The histogram indicates the distribution of genes by average fold-change upon <i>unc-62</i> RNAi. For 1699 genes with intestine-enriched expression <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-McGhee1" target="_blank">[23]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Pauli1" target="_blank">[33]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Spencer1" target="_blank">[34]</a> as well as the subset of 291 genes that also decrease expression with age <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Budovskaya1" target="_blank">[10]</a>, we determined the average mean-centered fold-change from triplicate RNA-seq experiments of <i>unc-62</i> RNAi as compared to controls. …”
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Nasal mucociliary clearance was decreased in <i>Ttll1</i><sup>−/−</sup> mice.
Published 2015“…In the <i>Ttll1</i><sup>−/−</sup> mice, a larger amount of Evans blue persisted in the nasal cavity and a lesser amount was swallowed compared with that in the wild-type (WT) mice (mean ± SEM, n = 5, *P < 0.005 by two-tailed Student's t test).…”
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PSG-specific <i>Fzr</i> mutation decreases the expression of silk protein genes.
Published 2023“…Scale bar, 1cm. WT, wild type. L5D3, the third day of the fifth larval instar; L5D5, the fifth day of the fifth larval instar; W0, just wandering.…”
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RT-qPCR analysis of congenital diaphragmatic hernia lungs showed an increase in distal epithelial progenitor and a decrease in type 1 alveolar cells.
Published 2019“…<p>E17.5 CDH lungs demonstrated a decrease in mRNAs identifying alveolar epithelial type I cells (<i>Hopx</i>, <i>Pdpn</i>) while distal epithelial progenitor marker <i>Id2</i> was increased. …”