Clinical and genetic characteristics of 5 patients harboring mutations in the <i>NR5A1</i> gene. by Jana Malikova (615672)

Subjects:

<i>Mertk</i>^<i>-/-</i> macrophages exhibit unpolarized distribution of filamentous actin and myosin II, and decreased FAK phosphorylation. by Yong Tang (161879)

“…Scale bars in (A) and (B), 5 μm. (C) Western blotting shows decreased FAK phosphorylation at tyrosine 397 after addition of apoptotic T cells for the indicated time points. …”

Metabolites which were (A) reversibly decreased and (B) reversibly increased with smoking. by Charmion I. Cruickshank-Quinn (595143)

“…TG = triglyceride, CDP = cytidine-diphosphate, DG = diglyceride, PC = phosphatidylcholine, PS = phosphatidylserine, TG = triglyceride, PA = phosphatidic acid. Fold change ≥1.5; <i>p</i>-value≤0.05, x-axis = Log2 normalized abundance scale; Error bars represent 95% confidence; Significance values *≤0.05, **≤0.01, ***≤0.001.…”

Simultaneous ablation of Syt1 and Syt7 decreases the RRP size at inhibitory synapses: Rescue by WT but not mutant Syt1 or Syt7. by Taulant Bacaj (803415)

“…Recordings were performed in the presence of 1 μM tetrodotoxin, 20 μM CNQX, and 50 μM AP5 to isolate inhibitory currents. <b>B.</b> Simultaneous ablation of Syt1 and Syt7 decreases the RRP size of inhibitory synapses in a manner that is rescued by WT Syt7 (Syt1^WT) but not Syt7 with mutations in the top C2 domain sequences containing the Syt7 Ca²⁺ binding sites (Syt7^C2A*^B*). …”

Increased body fat, glucose and PAI-1 and decreased adiponectin levels in 6 wk old WT offspring exposed to HF IU/L. by Patricia M. Vuguin (587226)

Synthesis of 1<i>H</i>‑Pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl Soft-Lewis Basic Complexants via Metal and Oxidant Free [3 + 2] Dipolar Cycloaddition of Terminal Ethynyl Pyridine... by Giri Babu Veerakanellore (7388243)

Subjects:

Synthesis of 1<i>H</i>‑Pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl Soft-Lewis Basic Complexants via Metal and Oxidant Free [3 + 2] Dipolar Cycloaddition of Terminal Ethynyl Pyridine... by Giri Babu Veerakanellore (7388243)

Subjects:

Sonication decreases toxicity of the Vicilin, Cupin-1.1, and Cupin-1.2 fibrils. by Kirill S. Antonets (4807410)

A Y45F mutation in hepatitis C virus NS4A causes a decrease in infectious viral titer. by Allison E. Roder (6312761)

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

Decrease of CXCL1 message and neutrophil counts in TLR4 deficient liver and after antibiotic treatment. by Amélie E. Bigorgne (2579386)

The functional half-life of WNV decreases in the presence of virus-specific antibody. by Kimberly A. Dowd (129927)

(R)-albuterol decreases cytokine mRNA levels in activated T cells by Marcela A Ferrada (41716)

“…RNA was isolated. Levels of IL-2, IL-13 and IL-6 (A, B, C) were measured by real time PCR. …”

Signatures of the Protein Folding Pathway in Two-Dimensional Ultraviolet Spectroscopy by Jun Jiang (149215)

“…The complexity of signals decreases as the conformational entropy decreases in the course of the folding process. …”

VRK1 overexpression is seen in human breast cancer and is associated with decreased relapse-free survival. by Aye M. Mon (5714912)

“…Data for cancer subtypes are shown in boxes numbered 1–11: 1: benign breast neoplasm (rank 6459, 1.4 fold-change, NS), 2: breast carcinoma (rank 833, 1.5 fold-change, p = 3.83x10^-5), 3: breast phyllodes tumor (rank 512, 1.2 fold-change, p = 0.002), 4: ductal breast carcinoma in situ (rank 1969, 1.5 fold-change, p = 0.002), 5: invasive breast carcinoma (rank 1060, 1.6 fold-change, p = 1.28x10^-5), 6: invasive ductal and invasive lobular breast carcinoma (rank 941, 1.5 fold-change, p = 6.76x10^-22), 7: invasive ductal breast carcinoma (rank 613, 1.5-fold change, p = 2.71x10^-71), 8: invasive lobular breast carcinoma (rank 947, 1.3 fold-change, p = 3.64x10^-28), 9: medullary breast carcinoma (rank 400, 1.8 fold-change, p = 3.25x10^-12), 10: mucinous breast carcinoma (rank 1932, 1.4 fold-change, p = 7.41x10^-10) and 11: tubular breast carcinoma (rank 1253, 1.4 fold-change, p = 1.24x10^-17). …”

Dox-inducible expression of HA-MAD1 in colon is sufficient to decrease p53 expression and cause chromosome missegregation. by Sarah E. Copeland (13951506)

Subjects:

HDM-specific IgE levels decreased in response to TSLPR ablation in chronic model of asthma mice. by Latifa Koussih (326043)

Decreased 3’-phosphatase activity in nuclear extracts from mutant ATXN3-expressing cells, and from SCA3 mouse brain regions. by Arpita Chatterjee (529752)

Genes showing upregulated (>2-fold increase) or downregulated (0.5-fold decrease) mRNA expression by 48-hr methylglyoxal treatment. by Kiyoshi Mori (289003)

VH14PEST decreases the toxicity of α-Syn as measured by a proteostatic assay with mhttex1-72QGFP. by David C. Butler (261919)