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Loss of ALS2 results in decreased levels of the lysosome-dependent degradation of LC3 in fibroblasts.
Published 2010“…Fibroblasts from wild-type (WT) and <i>Als2</i><sup>−/−</sup> mice were either left unstarved (0 hr) (upper) or starved for 6 hr (lower). It is notable that a 6 hr of starvation leads to decreased levels of the LC3- and p62-immunoreactive signals in WT cells, but not in <i>Als2</i><sup>−/−</sup> cells. …”
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β<sub>2</sub>-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D
Published 2011“…We then measured the amount and activity of PDE4, and found ∼2-fold greater expression and activity in asthmatic ASM compared to non-asthmatic ASM. …”