A Novel Splice-Site Mutation in Angiotensin I-Converting Enzyme (ACE) Gene, c.3691+1G>A (IVS25+1G>A), Causes a Dramatic Increase in Circulating ACE through Deletion of the Transmem... by Alexandre Persu (396983)

“…The levels of renin-angiotensin-aldosterone system components in the mutated cases and wild-type controls were similar, both at baseline and after 50 mg captopril. Compared with non-affected members, quantification of ACE surface expression and shedding using flow cytometry assay of dendritic cells derived from peripheral blood monocytes of affected members, demonstrated a 50% decrease and 3-fold increase, respectively. …”

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron by Li Zhang (8200)

“…Our results indicated that the mean neutralization ED50 of these sera against Omicron decreased to 66, which is about 8.4-folds compared to the D614G reference strain (ED50 = 556), whereas the neutralization activity of other VOC and VOI pseudotyped viruses decreased only about 1.2–4.5-folds. …”

A- and D‑Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure–Activity Relationships... by Francisco Cortés-Benítez (4523380)

“…Decreasing the intratumoral androgen biosynthesis by using an inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is a strategy to treat prostate cancer. …”

TGFβ-induced suppression of deptor regulates collagen expression in proximal tubular epithelial cells. by Falguni Das (161719)

“…<p>(A–D) TGFβ decreases deptor resulting in increased mTORC1 and mTORC2 activity. …”

Image_1_Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota.tiff by Tejpal Gill (618904)

Image_2_Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota.tiff by Tejpal Gill (618904)

Data_Sheet_1_Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.docx by Junping Yin (839507)

“…This study revealed that (i) cigarette smoking is associated with an increased expression of ACE2 and TMPRSS2 and a decreased expression of cathepsin L; (ii) significant alternations in expression of ACE2, TMPRSS2, and cathepsin L were observed between current smokers and former smokers, but not between former smokers and never smokers; (iii) when compared with healthy controls with identical smoking status, patients with COPD or lung cancer showed negligible changes in expression of ACE2, TMPRSS2, and cathepsin L. …”

Morphological and functional protective effects of H₂S against NIHL. by Xu Li (23864)

“…The ABR threshold shift demonstrated a significant decrease on the 14th day in the NaHS group (47.00±2.60 dB SPL) compared to the control group (56.11±2.32 dB SPL) and the PPG group (56.88±2.82 dB SPL) (P<0.05).…”

Changes in PAX2 expression during tumor development in oviductal fimbriae in hens. by Elizabeth A. Paris (11191694)

“…Compared with normal fimbria, the intensity of PAX2 was significantly lower in fimbriae with tumor at early stage and decreased further in late stage (<i>P</i><0.0001). …”

Increased phosphorylated Akt by inhibition of ERK_1,2 activation. by Natalia Dünner (465700)

“…The p-Akt/Akt (black bars) increase and the p-ERK_1,2/ERK_1,2 (white bars) decrease after incubation of cell cultures with the inhibitors of ERK_1,2 activation (n = 5 donors). …”

Stochastic property of the two-state bacterial receptor model with the multiple methylation sites. by Masatoshi Nishikawa (363723)

“…<p>A. Schematic of the two-state bacterial chemoreceptor model. The state transitions between the active and inactive states take place with transition rates which are dependent on the ligand concentration . …”

IL-2-activated NK cells from patients exhibited antitumor capacities. by Giulia Fregni (349403)

“…Targets are monitored for cell adhesion for 5 h before and after addition of NK cells (arrow). NK cells (ratio 2/1) induce a rapid decrease of adherent target cell index (dotted line: 120 min after NK addition). …”

Minocycline administration ameliorates photoreceptor cell death in <i>Mertk</i>^−/−<i>Cx3cr1</i>^<i>GFP/+</i><i>Ccr2</i>^<i>RFP/+</i> mice. by Ryo Terauchi (10687481)

Capacity of the insect AST-A peptides to activate the <i>A</i>. <i>coluzzii</i> GPRALS. by Rute C. Felix (5664397)

(A–C) Effect of malonate, (D–F) effect of KCN and (A, B, D, E) proton leak kinetics by Nadeene Parker (53449)

“…Succinate (4 mM) was added at =− 1.5 min (see A) in the absence (open symbols) or presence (closed symbols) of 50 μM HNE. …”

Presentation_1_Low-Dose Mycophenolate Mofetil for Treatment of Neuromyelitis Optica Spectrum Disorders: A Prospective Multicenter Study in South China.PPTX by Qiao Huang (4386955)

“…The serum AQP4-IgG titer decreased in 50 cases (63%). The median Simple McGill pain score (SF-MPQ) was reduced in 65 patients (88%) with myelitis from 17 (range 0–35) to 11 (range 0–34) after treatment (P < 0.0001). …”

A vaginal drug delivery model by Mohd. Aamir Mirza (2561590)

“…Stearic acid and Compritol 888 (1:1, w/w ratio) as lipid, a mixture of 3% Poloxomer 188 and 0.5% sodium taurocholate as surfactant and organic to aqueous ratio of 10:50 was taken. …”

Diagnostic difference of nuclear receptors and KLF4. by Susan M. Corley (3590576)

Parameter estimates from 2-regime models reveal varying impacts of latitude. by Jonathan P. Drury (3251745)

“…<b>(c)</b> MC models estimated a decreased effect of competition in the tropics on bill pPC2. …”

Effect of morin on antioxidant status, MMP and transcriptional level of Bax and Bcl-2. by Radhika Kapoor (144345)

“…(d) m-RNA level of Bcl-2 and Bax, were amplified by RT-PCR and analyzed by 1.8% agarose gel electrophoresis followed by ethidium bromide staining. …”