Image_2_Is Proton Therapy a “Pro” for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database.pdf by Mudit Chowdhary (6016496)

“…On multivariate logistic analysis, the following factors were found to be significant for receipt of PRT (all p < 0.05): academic facility (odds ratio [OR] = 2.50), South (OR = 2.01) and West location (OR = 12.43), left-sided (OR = 1.21), ER-positive (OR = 1.59), and mastectomy (OR = 1.47); pT2-T4 disease predicted for decrease use (OR = 0.79). …”

Image_1_Is Proton Therapy a “Pro” for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database.pdf by Mudit Chowdhary (6016496)

“…On multivariate logistic analysis, the following factors were found to be significant for receipt of PRT (all p < 0.05): academic facility (odds ratio [OR] = 2.50), South (OR = 2.01) and West location (OR = 12.43), left-sided (OR = 1.21), ER-positive (OR = 1.59), and mastectomy (OR = 1.47); pT2-T4 disease predicted for decrease use (OR = 0.79). …”

Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near <i>CDKN2B-AS1</i>, <i>SIX6</i> and <i>GAS7</i> by Yukihiro Shiga (724428)

“…In addition, nominal correlation was observed between <i>CDKN2B-AS1</i> (rs2157719) and optic nerve head blood flow (β = -0.54 and -0.67 arbitrary units (AU), <i>P</i> = 2.00E-02 and 1.39E-02), between <i>SIX6</i> (rs33912345) and decreased total peripapillary retinal nerve fiber layer thickness (β = -2.16 and -2.82 μm, <i>P</i> = 4.68E-02 and 2.40E-02, additive and recessive model, respectively) and increased optic nerve head blood flow (β = 0.44 AU, <i>P</i> = 2.20E-02; additive model) and between <i>GAS7</i> (rs9913911) and increased cup volume (β = 0.03 mm³, <i>P</i> = 4.60E-02) and mean cup depth (β = 0.03 mm³, <i>P</i> = 4.11E-02; additive model) and decreased pattern standard deviation (β = -0.87 dB, <i>P</i> = 2.44E-02; dominant model).…”

IpgD enzymatic activity promotes the formation of infection foci by <i>S</i>. <i>flexneri</i> in HT-29 cells. by Volkan K. Köseoğlu (12055346)

DataSheet2_Label-free quantitative proteomic profiling reveals differential plasma protein expression in patients with obesity after treatment with liraglutide.pdf by Afshan Masood (8279052)

“…</p>Methods<p>A single-center, prospective study was undertaken to evaluate the changes in the plasma proteins after liraglutide 3 mg therapy in twenty patients (M/F: 7/13) with obesity (mean BMI 40.65 ± 3.7 kg/m²). Anthropometric and laboratory parameters were measured, and blood samples were collected at two time points: baseline, before initiating treatment (pretreatment group, PT), and after three months of receiving the full dose liraglutide 3 mg (posttreatment group, PoT). …”

DataSheet1_Label-free quantitative proteomic profiling reveals differential plasma protein expression in patients with obesity after treatment with liraglutide.xlsx by Afshan Masood (8279052)

“…</p>Methods<p>A single-center, prospective study was undertaken to evaluate the changes in the plasma proteins after liraglutide 3 mg therapy in twenty patients (M/F: 7/13) with obesity (mean BMI 40.65 ± 3.7 kg/m²). Anthropometric and laboratory parameters were measured, and blood samples were collected at two time points: baseline, before initiating treatment (pretreatment group, PT), and after three months of receiving the full dose liraglutide 3 mg (posttreatment group, PoT). …”

Age-related locomotor impairment (ARLI) in <i>cyc</i>⁰, <i>tim</i>⁰ and <i>Clk</i>^AR arrhythmic mutants. by Alexandra Vaccaro (148308)

Experimental procedure, stress induction, and TPIG. by Huagen Wang (12426247)

Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway by J. Wang (472325)

“…Esculetin significantly inhibited proliferation of HCC cells in a concentration- and time-dependent manner and with an IC50 value of 2.24 mM. …”

A regulatory gene network of foam-cell formation. by Josefin Skogsberg (88384)

“…CE accumulation (given as average percentage next to each node) was decreased (blue) by siRNA inhibition of 5 genes and increased (red) by inhibition of 2 genes; inhibition of 1 gene had no effect (black) (see also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000036#pgen-1000036-t003" target="_blank">Table 3</a>). …”

Distinct Roles for the vBcl-2-mediated Inhibition of Autophagy and Apoptosis in γHV68 Chronic Infections In Vivo. by Xiaofei E (82852)

“…At 28 dpi (D), 35 dpi (E), and 42 dpi (F), the decreased infectious center titers (top) of vBcl-2 mutant viruses, as compared to WT γHV68, were statistically significant [vBcl-2Δα1 versus vBcl-2AAA (42 dpi), <i>P</i> = 0.46; vBcl-2Δα1 versus WT γHV68 (42 dpi), <i>P</i> = 0.08; unpaired <i>t</i>-tests]. …”

Endogenous genes are up-regulated by Nrf1 and Nrf1β/LCR-F1 but also down-regulated by Nrf1γ and Nrf1δ. by Yiguo Zhang (512679)

“…The data are shown as fold changes (mean ± S.D) in gene knockdown by Nrf1-siRNA relatively compared to the scramble value (1.0 set). …”

Video2_Quantification of horizontal force for the EXER-GENIE® resisted sprint training device.mp4 by Jamie J. Ghigiarelli (8777849)

“…However, at heavier loads (loads ≥0.226 kg), the 60 m device had F_h values 50–85 N greater than those of the 36 m device. The coefficient of variation across the four trials was extremely high at light loads but sharply decreased to <10% at heavy loads. …”

Partial loss of neuregulin 1 type III (Nrg1III) does not impair axonal sorting and does not worsen the axonal sorting defects of laminin α2β1γ1 (Lm211)-deficient mice. by Monica Ghidinelli (4164244)

“…(E) Western blot analysis shows that the levels of the α2 chain of Lm211 are not decreased in sciatic nerves of <i>Nrg1III</i>^<i>+/−</i> mice. …”

Time course development of insulin resistance, adipose and liver inflammation. by Petra Mulder (462809)

Ethanol exposure significantly reduced the number of proliferating cells compared to untreated controls in O2 neuromasts of Brn3c GFP-larvae. by Phillip M. Uribe (285454)

Water temperature affects aggressive interactions in a Neotropical cichlid fish by Manuela L. Brandão (5021027)

A trend in discussions about the endemic blues and daily responsibilities. by Seoyoung Kim (2603596)

Relationship between ground slope and thoraco-abdominal coordination (PhA) during the run. by Eva Bernardi (3897652)

“…<p>The ground slope values were grouped into four classes, each associated with a mean PhA value. When the slope increased to over 30%, a significant increase in PhA was observed, representing a decrease in thoraco-abdominal coordination. …”

Table_1_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.DOCX by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”