Meth induces a biphasic and depressive effect on cardiac electrophysiology. by Jimmy Zhang (159595)

Image_4_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

Image_3_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

Image_1_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

Image3_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.TIF by Meng-meng Liu (18241785)

Image4_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.TIF by Meng-meng Liu (18241785)

<b>Prescribing trends of anti-diabetes medications near end-of-life among adults with type 2 diabetes: a cohort study</b> by Alexander Kutz (3172095)

“…</p><p dir="ltr">Results</p><p dir="ltr">Among 975,407 community-dwelling Medicare beneficiaries with T2D, the use of anti-diabetes medications within 1 year of death slightly increased from 71.4% during the first 6-month period in 2015 to 72.9% (standardized mean difference [SMD], -0.03) during the second 6-month period in 2019. …”

Effect of MMA on luciferase reporter activity in HepG2 cells transfected with vectors containing <i>Gsta1</i>-ARE. by Ai Orimoto (389831)

“…Firefly luciferase activities were normalized to <i>Renilla</i> luciferase activities; for each vector, relative luciferase activities were expressed with the control value, obtained without exposure to MMA (1.342 for pGL4.23-2E, 0.203 for pGL4.24-2E, and 0.026 for pGL4.25-2E; the decrease of basal luciferase activity was dependent on protein destablization sequences), taken as 1.0. …”

Viral ORF57 inhibits eIF2α phosphorylation through down-regulation of PKR pathway. by Nishi R. Sharma (4543936)

“…<p>(A) Diagrams of four major stress pathways leading to phosphorylation of eIF2α via different kinases. PERK, PKR-like endoplasmic reticulum kinase; PKR, protein kinase R; GCN2, general control nonderepressible 2; HRI, heme regulated inhibitory kinase. …”

Over-expression of miR-200 in 4TO7 cells down-regulates Zeb2 expression, resulting in increased E-cadherin. by Derek M. Dykxhoorn (107661)

“…<p>(A) Zeb2 expression decreases and E-Cadherin (Cdh1) expression increases, analyzed by immunoblot relative to Gapdh, after transfection of 4TO7 cells with miR-200b and/or miR-200c. …”

DataSheet_1_Chlorophyll a fluorescence as a tool to monitor physiological status in the leaves of Artemisia ordosica under root cutting conditions.docx by Ying Liu (18461)

“…Through the analysis of JIP parameters and the established energy pipeline model, it was found that the energy capture efficiency and electron transfer efficiency of photosystem II decreased as the root cutting ratio increased. Therefore, we also inferred that the threshold for the plant root cutting ratio at which leaf photosynthetic mechanisms begin to change is 30–50%.…”

Histological findings of the tibial articular cartilage at a high magnification. by Ikufumi Takahashi (5146823)

The weak activator Nrf1β/LCR-F1 is negatively regulated by its CTD. by Yiguo Zhang (512679)

“…The <i>left two panels</i> show western blotting of some of the above-transfected cell lysates with antibodies against either V5 (<b><i>a1</i></b>) or Xpress (<b><i>a2</i></b>). …”

A checkboard of microbial culture to show positional plate effects. by Sam Barker (4832121)

“…Maximum signal variance was 11.2%CV, with Z’ = 0.68 (Calculation: Mean of positive wells = 204,371, SD = 15,179; mean of negative wells = 37,339, SD = 2,532). …”

<i>Mll2^Gdf9</i> cKO oocytes show loss of bulk H3K4me2 and H3K4me3 as well as H4 hyperacetylation. by Claudia V. Andreu-Vieyra (243666)

“…In contrast, a decrease in H3K4me2 (B) and H3K4me3 (C) levels was observed in <i>Mll2^Gdf9</i> cKO oocytes (B and C, lower panels) compared to controls (B and C, upper panels). …”

Opposing regulation of ARE-driven reporter genes by distinct Nrf1 isoforms. by Yiguo Zhang (512679)

“…The <i>upper two panels</i> represent similar images from different independent gels, on which location of Nrf2 migration is <i>arrowed</i>, whilst a non-specific protein band is <i>starred</i> (*). …”

Epithelialization of healing wounds in wild type and <i>Vegfa</i>^∂/∂ mice. by Domenic Ciarlillo (4233637)

Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies by Hossein Khorramdelazad (15317069)

“…Moreover, treatment with 60 μg/mL of <b>A1</b> and 100 ng/mL of CXCL12 for 72 h significantly decreased the number of cells expressing the CXCR4 receptor compared to the control group treated with CXCL12. …”

Figure 2 from Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian Cancer by Robert J. Lake (22408833)

“…<b>C,</b> Auranofin response in OVCAR3 cells stably expressing <i>NOTCH3</i> shRNA_3A. Data are means ± SEM (<i>n</i> = 2 biological replicates). …”

Image 1_A comprehensive immune repertoire signature distinguishes pulmonary infiltration in SARS-CoV-2 Omicron variant infection.jpeg by Xuechuan Li (14430114)

“…</p>Results<p>Patients with pulmonary infiltration exhibit lymphopenia, a decreased proportion of the overall TCR repertoire alongside an increased BCR repertoire, reduced IGHD and IGHM isotype expression, a shorter mean CDR3 length for TRG, and a longer mean length for TRD, as well as diminished clonality and diversity in the TCR/BCR repertoire. …”