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Increasing temperature decreases oxygen concentration and decreasing oxygen content decreases neuronal excitability.
Published 2012“…Increasing temperature can dramatically decrease oxygen levels. B. Response of layer 2/3 pyramidal cells (n = 5) to the intracellular injection of a depolarizing current pulse (200 pA, 500 ms) at different temperatures (same experiments as in A). …”
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Metformin inhibits glutaminase activity in a dose dependent manner: from 17.5% at 10 mM up to 68% at 100 mM (A) (* p<0.05).
Published 2014“…<p>This effect, analyzed by Dixon plot, showed competitive inhibition kinetics, with a K<sub>i</sub> of 14.28 mM (B). In Caco2 cells, metformin 20 mM showed 24% inhibition of glutaminase activity at 72 hours compared to control cultures (p<0.05) (glutamate production was decreased from 26.85±0.74 µM to 19.9±2.05 µM; p<0.05) (C).…”
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FTY720 treatment decreased tumor growth in a xenograft model of hepatoblastoma.
Published 2019“…<p>(A) HuH6 cells (2.5 x 10<sup>6</sup> cells in 25% Matrigel) were injected subcutaneously into the right flank of 6-week-old female athymic nude mice. …”
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Retigabine and ML213 decrease the constriction tone of human detrusor strips.
Published 2015“…<p>(A) The original DSM tension recordings illustrate the relaxatory effect of retigabine and ML213, which are K<sub>v</sub>7.2–7.5 and K<sub>v</sub>7.2/7.4/7.5 channel activators, respectively. …”
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112
METH decreased basal pERK1/2 levels and potentiated ERK1/2 phosphorylation induced by 6-OHDA.
Published 2013“…METH decreased activation of ERK 1/2 in a concentration-dependent manner (0, 0.5, and 1 mM at the 24 hr time point) and enhanced the activation of ERK1/2 after 6-OHDA exposure. …”
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113
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sC5b-9 patients decrease in patients treated with mycophenolate mofetil.
Published 2015“…When analyzed separately based upon treatment, the decrease in sC5b-9 levels was due to a decrease in patients treated with mycophenolate mofetil (P < 0.001 by linear regression; n = 12 for all time-points). …”
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115
MK-STYX decreases RhoA activation.
Published 2014“…<p>(<b>A</b>) PC12 cells were transfected with pMT2 or pMT2-FLAG-MK-STYX-FLAG. 24 hr post-transfection cells were stimulated with 100 ng/ml NGF, and lysed at the indicated time points. …”
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116
Corticosterone treatment decreases MMP-2 promoter activity.
Published 2012“…Whole cell lysates were used for qRT-PCR. MMP-2 mRNA levels were decreased with corticosterone treatment (A) (p = 0.006, n = 5). …”
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117
Chemokines, with the exception of CXCL1 and MCP-1, decrease acutely following 5 Gy IR.
Published 2024Subjects: -
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