Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. by Seidel, Monika

“…The arrhythmia-linked R176Q mutation within the β8-β9 loop decreases N-terminus tetramerization but does not affect RyR2 subunit tetramerization or the N-terminus interaction with C-terminus. …”
Get full text
Get full text

Assessment of Dapagliflozin Effectiveness as Add-on Therapy for the Treatment of Type 2 Diabetes Mellitus in a Qatari Population by Al AdAwi R.M.

“…The effectiveness of dapagliflozin in the management of type-2 diabetes mellitus (T2-DM) is an essential issue for establishing a basis for prescribing dapagliflozin. …”
Get full text
Get full text

Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria by Al-Sadeq, Duaa W.

“…Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). …”
Get full text
Get full text
Get full text

Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis by Smatti, Maria K.

“…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations. Conclusion: Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …”
Get full text
Get full text

Simulation of natural convective heat transfer and entropy generation of nanoparticles around two spheres in horizontal arrangement by Basma, Souayeh

Get full text
Get full text
Get full text

The Cardiovascular Benefits of Empagliflozin, A Sodium Glucose Cotransporter Inhibitor: Is NHE1 a Viable Target? by Al-Shamasi, Al-Anood

“…In our study, we examine the cellular interplay between NHE1 and SGLT1/SGLT2 in a non-diabetic in vitro model. We characterized H9c2 cardiomyoblasts stimulated with Angiotensin II (ANG II) 100nM in the presence and absence of EMPA (500nM) and measured cardiomyocyte hypertrophy and the expression of NHE1 and SGLT1/2. …”
Get full text
Get full text

Impacts of CO2-induced seawater acidification on coastal Mediterranean bivalves and interactions with other climatic stressors by Range, P.

Get full text
Get full text

Epidemiology of herpes simplex virus type 2 in Europe: systematic review, meta-analyses, and meta-regressions by Alareeki, Asalah

Get full text
Get full text
Get full text

MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS by Hourani, Shireen Bayan

“…Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. …”
Get full text

Utilization of Two Microalgae Species, Synechococcus sp. and Cheatoceros sp., for Aquatic Toxicity Assessments in the Qatari Marine Environmen by Bacha, Sarah

Get full text
Get full text

Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach. by Thirumal Kumar, D

“…The present study aims to understand the impact of missense mutations in the interacting sites of the MSH2-MSH6 protein complex. MSH6 is unstable due to the disordered N-terminal domain. …”
Get full text
Get full text

MHD effects on nanofluid with energy and hydrothermal behavior between two collateral plates application of new semi analytical technique by Sheikholeslami, Mohsen

Get full text
Get full text
Get full text

A process for CO2 capture and brine salinity reduction through reaction with potassium hydroxide: A multi-stage evaluation by Mourad, Aya A-H.

Get full text
Get full text

In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway by Kuttikrishnan, Shilpa

Get full text
Get full text

Synthesis and characterization of stir casted Cu-ZrO2-Graphite hybrid metal matrix composites for thermal management structures by Mittal, Prateek

“…The properties of the prepared MMCs were found to be dependent on the reinforcements content present in the MMCs. ZrO2 and Graphite reinforcements were added (0.5–0.5, 1.0–1.0, 1.5–1.5 and 2.0–2.0 wt %) in the four composite samples prepared via stir casting. …”
Get full text
Get full text
Get full text

Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells by Mannino, Federica

Get full text
Get full text
Get full text

Results from the first culturally tailored, multidisciplinary diabetes education in Lebanese adults with type 2 diabetes: effects on self-care and metabolic outcomes by Sukkarieh-Haraty, Ola

“…This pilot-study tested the effect of culturally-tailored education targeting diabetes selfcare on glycemia and cardiovascular risk factors of Lebanese with type 2 diabetes mellitus (T2DM) (n = 27; Age: 61 ± 10 yrs, 59% males, HbA1c: 8.98 ± 1.38%). …”
Get full text
Get full text
Get full text

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …”
Get full text
Get full text
Get full text

Characterization of polysulfone/diisopropylamine 1-alkyl-3-methylimidazolium ionic liquid membranes: high pressure gas separation applications by Khraisheh M.

“…Thermogravimetric analysis measurement (TGA), differential scanning calorimeter (DSC), dynamic mechanical analysis, and the tensile properties of the membranes are studied in order to optimize the efficiency of separating CO2 from CO2/N2 mixture and CO2/CH4. TGA showed that pure PSF is a highly thermostable polymer, of which the 5% weight loss temperature is above 150 C. …”
Get full text
Get full text

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath, Chethan

“…Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue. …”
Get full text
Get full text