Showing 1,041 - 1,060 results of 229,223 for search '(( 2 step decrease ) OR ( 10 ((nn decrease) OR (((mean decrease) OR (a decrease)))) ))', query time: 1.35s Refine Results
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    PS1 downregulation in new neurons decreases dendritic arborization and spine density. by Jacqueline A. Bonds (358407)

    Published 2015
    “…PS1 downregulation results in decreased number of spines <b>(C)</b> as a function of increasing distance from the soma (two-way ANOVA (treatment and distance from soma) F<sub>(treatment)1,60</sub> = 13.10, P<0.001, F<sub>(distance)19,60</sub> = 3.18, P<0.001) and mean spine density <b>(D)</b> (unpaired t-test, *P<0.05). …”
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    Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation by Tamara Seredenina (213942)

    Published 2011
    “…</p> <h3>Methodology/Principal Findings</h3><p>We used protein-encoding and shRNA-expressing lentiviral vectors to evaluate the effects of RGS2, RASD2, STEP and NNAT downregulation in HD. Of these four genes, only RGS2 and RASD2 modified mutant htt fragment toxicity in cultured rat primary striatal neurons. …”
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